Loss of hepatic Mboat7 leads to liver fibrosis

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes

(2020) Marica Meroni et al.   EBioMedicine

Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis

(2019) S. Pelusi et al.   Clinical Gastroenterology and Hepatology

MBOAT7 is anchored to endomembranes by six transmembrane domains

(2019) Andrea Caddeo et al.   JOURNAL OF STRUCTURAL BIOLOGY

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

(2019) Robert N Helsley et al.   eLife

Genetics of alcoholic liver disease and non-alcoholic steatohepatitis

(2018) Emma Scott et al.   CLINICAL MEDICINE

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

The Membrane-bound O-Acyltransferase7 rs641738 Variant in Pediatric Nonalcoholic Fatty Liver Disease

(2018) Anna Di Sessa et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Lysophosphatidylinositols, from Cell Membrane Constituents to GPR55 Ligands

(2018) Mireille Alhouayek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird

(2018) Rebecca E. Koch et al.   Nature Communications

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

(2018) Pavel Strnad et al.   GUT

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

Low hepatic copper content and PNPLA3 polymorphism in non-alcoholic fatty liver disease in patients without metabolic syndrome

(2017) Albert Friedrich Stättermayer et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Pro-resolving mediators produced from EPA and DHA: Overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases

(2016) Cristina López-Vicario et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Molecular Pathogenesis of NASH

(2016) Alessandra Caligiuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

(2016) Marcin Krawczyk et al.   JOURNAL OF LIPID RESEARCH

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling

(2016) Bao-Jun Yang et al.   Nature Communications

Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome

(2016) Susanne Sales et al.   Scientific Reports

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

Analysis of eicosanoids by LC-MS/MS and GC-MS/MS: A historical retrospect and a discussion

(2014) Dimitrios Tsikas et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis

(2014) Rohit Loomba et al.   JOURNAL OF LIPID RESEARCH

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP2 in the Mouse

(2013) Karen E. Anderson et al.   PLoS One

The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55

(2013) Atsushi Yamashita et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Depletion ofmboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling inCaenorhabditis elegans

(2012) Hyeon-Cheol Lee et al.   GENES TO CELLS

The putative cannabinoid receptor GPR55 promotes cancer cell proliferation

(2010) G Hu et al.   ONCOGENE

The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

(2010) C Andradas et al.   ONCOGENE

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent progress on acyl CoA: lysophospholipid acyltransferase research

(2008) Hideo Shindou et al.   JOURNAL OF LIPID RESEARCH