SIRT7‐mediated modulation of glutaminase 1 regulates TGF‐β‐induced pulmonary fibrosis

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

(2019) Lisha Xiang et al.   Cell Death & Disease

Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis

(2019) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma

(2019) Raj Shah et al.   CANCER RESEARCH

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

(2019) Ana Galan-Cobo et al.   CANCER RESEARCH

miR‐145 inhibits glutamine metablism through c‐myc/GLS1 pathways in ovarian cancer cells

(2019) Jie Li et al.   CELL BIOLOGY INTERNATIONAL

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells

(2019) Larissa Menezes dos Reis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO1/3: Potential suppressors of fibrosis

(2018) Zhenlong Xin et al.   AGEING RESEARCH REVIEWS

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation

(2018) Jing Ge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sirtuins and Accelerated Aging in Scleroderma

(2018) Anne E. Wyman et al.   Current Rheumatology Reports

Gankyrin drives metabolic reprogramming to promote tumorigenesis, metastasis and drug resistance through activating β-catenin/c-Myc signaling in human hepatocellular carcinoma

(2018) Ruiqi Liu et al.   CANCER LETTERS

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

(2017) Jeong-Han Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts

(2017) Xiao-Xiang Zhai et al.   Molecular Medicine Reports

Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation

(2017) Stephane Esnault et al.   PLoS One

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Drug Treatment of Idiopathic Pulmonary Fibrosis

(2016) William J. Canestaro et al.   CHEST

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

(2016) Jae-Seon Lee et al.   Cell Death & Disease

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

(2016) Diancheng Wang et al.   PLoS One

Nintedanib and Pirfenidone. New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

(2015) Jun Wei et al.   Arthritis & Rheumatology

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

(2015) Yue-Zhi Lee et al.   Oncotarget

Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

(2014) Pawel Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs

(2013) Andrea M. Foskett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases

(2013) Mahefatiana Andrianifahanana et al.   FASEB JOURNAL

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Mechanisms in Progressive Idiopathic Pulmonary Fibrosis

(2012) Mark P. Steele et al.   Annual Review of Medicine

Glutamine metabolism links growth factor signaling to the regulation of autophagy

(2012) Kristan E. van der Vos et al.   Autophagy

Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation

(2012) William P. Katt et al.   MOLECULAR CANCER THERAPEUTICS

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Chromatin Connections to Pluripotency and Cellular Reprogramming

(2011) Stuart H. Orkin et al.   CELL

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells

(2010) Charalambos Michaeloudes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor  

(2010) M. Andrianifahanana et al.   CANCER RESEARCH

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

(2010) C. H. Eng et al.   Science Signaling

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection

(2009) David Verhoeven et al.   VIROLOGY

Distinct Roles for Mammalian Target of Rapamycin Complexes in the Fibroblast Response to Transforming Growth Factor- 

(2008) R. A. Rahimi et al.   CANCER RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

How the Smads regulate transcription

(2007) Sarah Ross et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY