Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes

Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1

(2019) Hatem Maamoun et al.   Frontiers in Physiology

Endoplasmic reticulum stress‐dependent autophagy inhibits glycated high‐density lipoprotein‐induced macrophage apoptosis by inhibiting CHOP pathway

(2019) Hua Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within

(2019) Jia Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium

(2018) Roberto Villalobos-Labra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses

(2018) Amado Carreras-Sureda et al.   CELL CALCIUM

The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia

(2018) Joey P. Granger et al.   CURRENT HYPERTENSION REPORTS

Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress

(2018) Natarajan Suganya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The interaction between XBP1 and eNOS contributes to endothelial cell migration

(2018) Junyao Yang et al.   EXPERIMENTAL CELL RESEARCH

Vascular endothelium dysfunction: a conservative target in metabolic disorders

(2018) Shalini Jamwal et al.   INFLAMMATION RESEARCH

High expression of active ATF6 aggravates endoplasmic reticulum stress‑induced vascular endothelial cell apoptosis through the mitochondrial apoptotic pathway

(2018) Jingyong Huang et al.   Molecular Medicine Reports

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Endoplasmic Reticulum Stress in Metabolic Disorders

(2018) Rose Ghemrawi et al.   Cells

Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33

(2018) Yan Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice

(2018) Han Yingchun et al.   Lipids in Health and Disease

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis

(2018) Xun Wu et al.   Redox Biology

Insulin resistance: Review of the underlying molecular mechanisms

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs

(2018) Hai-na Zhang et al.   LIFE SCIENCES

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes

(2018) Vivek Kumar Pandey et al.   LIFE SCIENCES

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

(2018) Roberto Villalobos-Labra et al.   MOLECULAR ASPECTS OF MEDICINE

The Impact of Obesity on the Cardiovascular System

(2018) Imre Csige et al.   Journal of Diabetes Research

NF-κB Signaling in Targeting Tumor Cells by Oncolytic Viruses—Therapeutic Perspectives

(2018) Justyna Struzik et al.   Cancers

Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells: Role of ER stress

(2017) Natalia Di Pietro et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Unraveling the role of ER stress inhibitors in the context of metabolic diseases

(2017) Chodisetty Sarvani et al.   PHARMACOLOGICAL RESEARCH

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress

(2017) Ker Woon Choy et al.   PLoS One

Glycation of paraoxonase 1 by high glucose instigates endoplasmic reticulum stress to induce endothelial dysfunction in vivo

(2017) Wei Yu et al.   Scientific Reports

Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

(2016) L. K. Walsh et al.   CLINICAL SCIENCE

Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?

(2016) Taher Mandviwala et al.   Current Atherosclerosis Reports

Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis

(2016) Yunzhou Dong et al.   Diabetes & Vascular Disease Research

Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease

(2016) Qiang Tong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Roles of LOX-1 in microvascular dysfunction

(2016) Valter Lubrano et al.   MICROVASCULAR RESEARCH

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

(2016) Soo-Kyoung Choi et al.   Scientific Reports

Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin

(2015) Jeong-a Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII

(2015) Haibo Li et al.   CARDIOVASCULAR RESEARCH

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes

(2015) Maulasri Bhatta et al.   DIABETOLOGIA

Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model

(2015) Eun Soo Lee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

(2014) Abdelali Agouni et al.   BIOCHEMICAL PHARMACOLOGY

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction

(2014) Maria Galán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells

(2014) N. Suganya et al.   CELL PROLIFERATION

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair

(2014) Kelly E. Johnson et al.   Advances in Wound Care

Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat

(2013) Kathryn M. Spitler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Activation of the Unfolded Protein Response in Vascular Endothelial Cells of Nondiabetic Obese Adults

(2013) Rachelle E. Kaplon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperuricemia induces endothelial dysfunction via mitochondrial Na+/Ca2+ exchanger-mediated mitochondrial calcium overload

(2012) Quan Hong et al.   CELL CALCIUM

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

(2012) Justin Hassler et al.   DEVELOPMENTAL CELL

Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes

(2012) E. Panzhinskiy et al.   DIABETOLOGIA

A Novel Role for Epidermal Growth Factor Receptor Tyrosine Kinase and Its Downstream Endoplasmic Reticulum Stress in Cardiac Damage and Microvascular Dysfunction in Type 1 Diabetes Mellitus

(2012) Maria Galán et al.   HYPERTENSION

New insights into ER stress-induced insulin resistance

(2012) Mélissa Flamment et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Endothelium-mediated control of vascular tone: COX-1 and COX-2 products

(2011) Michel Félétou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice

(2011) Arun Prasath Lakshmanan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia–reperfusion injury

(2011) ZhenZhen Zhang et al.   NEUROSCIENCE LETTERS

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Endoplasmic Reticulum Stress-C/EBP Homologous Protein Pathway-Mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques

(2010) Hiroto Tsukano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells

(2010) S. Lenna et al.   JOURNAL OF IMMUNOLOGY

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells

(2009) Yayoi Natsume et al.   TOXICOLOGY

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets

(2008) Maria Potenza et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

(2008) E. R. Duncan et al.   DIABETES

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting

(2008) W Todd Cade   PHYSICAL THERAPY