Theranostic applications of smart nanomedicines for tumor-targeted chemotherapy: a review

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

(2020) Siavash Iravani et al.   Environmental Chemistry Letters

Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy

(2019) V. M. Petriev et al.   Scientific Reports

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

(2019) Fei Peng et al.   Nature Nanotechnology

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging

(2019) Rohit Bavi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrating Nanotechnology into Cancer Care

(2019) Piotr Grodzinski et al.   ACS Nano

Nanocarrier-mediated co-delivery systems for lung cancer therapy: recent developments and prospects

(2019) Muhammad Asim Farooq et al.   Environmental Chemistry Letters

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

(2019) Md Aquib et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy

(2019) Qianqian Sun et al.   BIOMATERIALS

Targeting Tumor Microenvironment by Small-Molecule Inhibitors

(2019) Shangwei Zhong et al.   Translational Oncology

Perspectives on the past, present, and future of cancer nanomedicine

(2018) Yu Seok Youn et al.   ADVANCED DRUG DELIVERY REVIEWS

Combinational strategy for high-performance cancer chemotherapy

(2018) Si-Yong Qin et al.   BIOMATERIALS

Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles

(2018) Jinping Wang et al.   CHEMISTRY OF MATERIALS

Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation

(2018) Hao Zhang et al.   Small

pH-Responsive PEG-Doxorubicin-Encapsulated Aza-BODIPY Nanotheranostic Agent for Imaging-Guided Synergistic Cancer Therapy

(2018) Dapeng Chen et al.   Advanced Healthcare Materials

Smart pH-responsive nanoparticles in a model tumor microenvironment for enhanced cellular uptake

(2018) Jie Pan et al.   JOURNAL OF MATERIALS SCIENCE

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

(2018) Si-Yong Qin et al.   Small

Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine

(2018) Jin-Zhi Du et al.   ACCOUNTS OF CHEMICAL RESEARCH

Advances in HER2-Targeted Therapy: Novel Agents and Opportunities Beyond Breast and Gastric Cancer

(2018) Funda Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Nanocarriers for drug delivery applications

(2018) Munusamy Chamundeeswari et al.   Environmental Chemistry Letters

Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes

(2018) Meghdad Abdollahpour-Alitappeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

Nanosystems for drug delivery of coenzyme Q10

(2017) Shweta Paroha et al.   Environmental Chemistry Letters

A Preliminary Study in Search of Potential Peptide Candidates for a Combinational Therapy with Cancer Chemotherapy Drug

(2017) Hussin A. Rothan et al.   International Journal of Peptide Research and Therapeutics

The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions

(2017) Annette Johansen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parameters Affecting the Enhanced Permeability and Retention Effect: The Need for Patient Selection

(2017) Az Alddien Natfji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Subcellular co-delivery of two different site-oriented payloads for tumor therapy

(2017) Qingqing Yang et al.   Nanoscale

Therapeutic implications of tumor interstitial acidification

(2017) Iryna Kolosenko et al.   SEMINARS IN CANCER BIOLOGY

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

(2017) Daniel A. Richards et al.   Chemical Science

Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity

(2017) Qing Zhou et al.   Theranostics

Enhanced bioreduction-responsive biodegradable diselenide-containing poly(ester urethane) nanocarriers

(2017) Chao Wei et al.   Biomaterials Science

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Facile synthesis of RGD-conjugated unimolecular micelles based on a polyester dendrimer for targeting drug delivery

(2017) Xiaoshan Fan et al.   Journal of Materials Chemistry B

Self-Assembled Bifunctional Peptide as Effective Drug Delivery Vector with Powerful Antitumor Activity

(2017) Rangrang Fan et al.   Advanced Science

Targeted Delivery of Docetaxel by Use of Transferrin/Poly(allylamine hydrochloride)-functionalized Graphene Oxide Nanocarrier

(2016) Fatemeh Nasrollahi et al.   ACS Applied Materials & Interfaces

The Application of Stimuli-Responsive VEGF- and ATP-Aptamer-Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells

(2016) Wei-Ching Liao et al.   ADVANCED FUNCTIONAL MATERIALS

Acidity-Triggered Tumor-Targeted Chimeric Peptide for Enhanced Intra-Nuclear Photodynamic Therapy

(2016) Kai Han et al.   ADVANCED FUNCTIONAL MATERIALS

Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma

(2016) Tao Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates

(2016) Robert V. Kolakowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates

(2016) Matthew R. Levengood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

(2016) Alessandra Graziadio et al.   BIOCONJUGATE CHEMISTRY

Acidity-responsive gene delivery for “superfast” nuclear translocation and transfection with high efficiency

(2016) Jing-Yi Zhu et al.   BIOMATERIALS

pH-activated size reduction of large compound nanoparticles for in vivo nucleus-targeted drug delivery

(2016) Yanbin Fan et al.   BIOMATERIALS

MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth

(2016) Daniela Kalafatovic et al.   BIOMATERIALS

Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment

(2016) Kun Zhang et al.   BIOMATERIALS

Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance

(2016) Juan Liu et al.   BIOMATERIALS

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

(2016) Karel Ulbrich et al.   CHEMICAL REVIEWS

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

(2016) Hong-Min Meng et al.   CHEMICAL SOCIETY REVIEWS

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

Bioengineered quantum dot/chitosan-tripeptide nanoconjugates for targeting the receptors of cancer cells

(2016) Alexandra A.P. Mansur et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

(2016) Shuang Jiang et al.   International Journal of Nanomedicine

Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: A robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy

(2016) Yan Zou et al.   JOURNAL OF CONTROLLED RELEASE

Fullerene (C 60 )-based tumor-targeting nanoparticles with “off-on” state for enhanced treatment of cancer

(2016) Jinjin Shi et al.   JOURNAL OF CONTROLLED RELEASE

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

(2016) Jeffrey C. Kern et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phenylboronic Acid-Cross-Linked Nanoparticles with Improved Stability as Dual Acid-Responsive Drug Carriers

(2016) Chunran Wang et al.   MACROMOLECULAR BIOSCIENCE

Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines

(2016) Hong-Xia Wang et al.   Nano Today

Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells

(2016) Shanghao Li et al.   Nanoscale

The missing link

(2016) Tiago Rodrigues et al.   Nature Chemistry

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release

(2016) Zhen Fan et al.   Nature Nanotechnology

Nanomedicines for renal disease: current status and future applications

(2016) Nazila Kamaly et al.   Nature Reviews Nephrology

Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice

(2016) Bai-Yu Lee et al.   Small

Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release

(2016) Jing-Jing Hu et al.   Small

Cyclo(RGD)-Decorated Reduction-Responsive Nanogels Mediate Targeted Chemotherapy of Integrin Overexpressing Human Glioblastoma In Vivo

(2016) Wei Chen et al.   Small

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

(2016) Padma Akkapeddi et al.   Chemical Science

Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients

(2016) Leonora S.F. Boogerd et al.   Oncotarget

Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects

(2016) Wei Tao et al.   Theranostics

Activable Cell-Penetrating Peptide Conjugated Prodrug for Tumor Targeted Drug Delivery

(2015) Hong Cheng et al.   ACS Applied Materials & Interfaces

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

(2015) Jinqiang Wang et al.   ACS Nano

Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin–Polylactide Nanoconjugates for Enhanced Cancer Therapy

(2015) Li Tang et al.   ACS Nano

Tuning Endothelial Permeability with Functionalized Nanodiamonds

(2015) Magdiel I. Setyawati et al.   ACS Nano

Ratiometric Biosensor for Aggregation-Induced Emission-Guided Precise Photodynamic Therapy

(2015) Kai Han et al.   ACS Nano

Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

(2015) Cassandra E. Callmann et al.   ADVANCED MATERIALS

Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia

(2015) Nianxi Zhao et al.   BIOMATERIALS

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

(2015) Jooyeon Ahn et al.   BIOMATERIALS

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

(2015) Dinggeng He et al.   CHEMICAL COMMUNICATIONS

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

(2015) Wei-Hai Chen et al.   CHEMICAL COMMUNICATIONS

DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intracellular GSH-controlled release

(2015) Changhui Liu et al.   CHEMICAL COMMUNICATIONS

Supramolecular Nanoparticles Constructed by DOX-Based Prodrug with Water-Soluble Pillar[6]arene for Self-Catalyzed Rapid Drug Release

(2015) Yu Cao et al.   CHEMISTRY OF MATERIALS

Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates

(2015) Yuqin Yao et al.   JOURNAL OF CONTROLLED RELEASE

Targeting CD44 expressing cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin

(2015) Leila Arabi et al.   JOURNAL OF CONTROLLED RELEASE

Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier

(2015) Ying-wen Hu et al.   JOURNAL OF CONTROLLED RELEASE

Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator

(2015) Akiko Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-delivery of a peptide-based prodrug for tumor-targeting therapy

(2015) Mengyun Peng et al.   Nano Research

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

(2015) Xiao-Gang Wang et al.   Nanoscale

An innovative pre-targeting strategy for tumor cell specific imaging and therapy

(2015) Si-Yong Qin et al.   Nanoscale

Dose-Dependent Therapeutic Distinction between Active and Passive Targeting Revealed Using Transferrin-Coated PGMA Nanoparticles

(2015) Ruhani Singh et al.   Small

Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery

(2015) Shi-Song Han et al.   Small

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer

(2015) Zhehai Wang et al.   Drug Design Development and Therapy

Stepwise-Acid-Active Multifunctional Mesoporous Silica Nanoparticles for Tumor-Specific Nucleus-Targeted Drug Delivery

(2014) Ze-Yong Li et al.   ACS Applied Materials & Interfaces

Back to Basics: Exploiting the Innate Physico-chemical Characteristics of Nanomaterials for Biomedical Applications

(2014) Chor Yong Tay et al.   ADVANCED FUNCTIONAL MATERIALS

Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models

(2014) Feng Li et al.   ADVANCED FUNCTIONAL MATERIALS

A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

(2014) Shi-Ying Li et al.   CHEMICAL COMMUNICATIONS

ATP-triggered anticancer drug delivery

(2014) Ran Mo et al.   Nature Communications

One-Pot Construction of Functional Mesoporous Silica Nanoparticles for the Tumor-Acidity-Activated Synergistic Chemotherapy of Glioblastoma

(2013) Ze-Yong Li et al.   ACS Applied Materials & Interfaces

Multi-Functional Envelope-Type Nanoparticles Assembled from Amphiphilic Peptidic Prodrug with Improved Anti-Tumor Activity

(2013) Jing-Xiao Chen et al.   ACS Applied Materials & Interfaces

Viral Mimicking Ternary Polyplexes: A Reduction-Controlled Hierarchical Unpacking Vector for Gene Delivery

(2013) Yiyan He et al.   ADVANCED MATERIALS

A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery

(2013) Changli Du et al.   BIOMATERIALS

Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment

(2013) Yanna Cui et al.   BIOMATERIALS

pH Responsive micelle self-assembled from a new amphiphilic peptide as anti-tumor drug carrier

(2013) Ju Liang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Doxorubicin-Loaded Cyclic Peptide Nanotube Bundles Overcome Chemoresistance in Breast Cancer Cells

(2013) Yongzhong Wang et al.   Journal of Biomedical Nanotechnology

Peptide-based carbon nanotubes for mitochondrial targeting

(2013) Alessia Battigelli et al.   Nanoscale

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

(2013) A. S. Wibowo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theranostic GO-Based Nanohybrid for Tumor Induced Imaging and Potential Combinational Tumor Therapy

(2013) Si-Yong Qin et al.   Small

A Dual-Responsive Mesoporous Silica Nanoparticle for Tumor-Triggered Targeting Drug Delivery

(2013) Dong Xiao et al.   Small

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

(2013) M.I. Setyawati et al.   Nature Communications

Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice

(2012) Biana Godin et al.   ADVANCED FUNCTIONAL MATERIALS

Molecular binding of self-assembling peptide EAK16-II with anticancer agent EPT and its implication in cancer cell inhibition

(2012) Sheng Lu et al.   JOURNAL OF CONTROLLED RELEASE

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

(2012) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Nanotoxicology and nanoparticle safety in biomedical designs

(2011) Esmaeil Biazar et al.   International Journal of Nanomedicine

Targeting the Tumor Microenvironment in Cancer: Why Hyaluronidase Deserves a Second Look

(2011) C. J. Whatcott et al.   Cancer Discovery

Imaging and drug delivery using theranostic nanoparticles

(2010) Siti M. Janib et al.   ADVANCED DRUG DELIVERY REVIEWS

Construction of surfactant-like tetra-tail amphiphilic peptide with RGD ligand for encapsulation of porphyrin for photodynamic therapy

(2010) Jing-Xiao Chen et al.   BIOMATERIALS

Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei

(2010) Hui-Yuan Wang et al.   JOURNAL OF CONTROLLED RELEASE

Nanotheranostics and Image-Guided Drug Delivery: Current Concepts and Future Directions

(2010) Twan Lammers et al.   MOLECULAR PHARMACEUTICS

Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery

(2010) Emilie Roger et al.   Nanomedicine

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Theranostic nanomedicine for cancer

(2008) Baran Sumer et al.   Nanomedicine

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA