Journal
SMALL
Volume 14, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201802417
Keywords
drug delivery; nanomedicine; target; tumor microenvironment; tumor therapy
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Funding
- National Natural Science Foundation of China [51503227, 51690152]
- Natural Science Foundation of Hubei province of China [2017CFB528]
- Fundamental Research Funds for the Central Universities, South-Central University for Nationalities [CZY18007]
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Efficacy and safety of chemotherapeutic drugs constitute two major criteria in tumor chemotherapy. Nanomedicines with tumor-targeted properties hold great promise for improving the efficacy and safety. To design targeted nanomedicines, the pathological characteristics of tumors are extensively and deeply excavated. Here, the rationale, principles, and advantages of exploiting these pathological characteristics to develop targeted nanoplatforms for tumor chemotherapy are discussed. Homotypic targeting with the ability of self-recognition to source tumors is reviewed individually. In the meanwhile, the limitations and perspective of these targeted nanomedicines are also discussed.
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