Back to the future: re-establishing guinea pig in vivo asthma models

Clinical phenotypes of bronchial hyperresponsiveness in school-aged children

(2018) Eun Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways

(2018) Li Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Asthma

(2018) Alberto Papi et al.   LANCET

A novel method for studying airway hyperresponsiveness in allergic guinea pigs in vivo using the PreciseInhale system for delivery of dry powder aerosols

(2018) A. J. Lexmond et al.   Drug Delivery and Translational Research

Inhalation of concentrated PM 2.5 from Mexico City acts as an adjuvant in a guinea pig model of allergic asthma

(2017) Carlos Iván Falcon-Rodriguez et al.   ENVIRONMENTAL POLLUTION

Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves

(2017) Michaela Kocmalova et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Route of Administration Affects Corticosteroid Sensitivity of a Combined Ovalbumin and Lipopolysaccharide Model of Asthma Exacerbation in Guinea Pigs

(2017) Alexander P. P. Lowe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma

(2017) Aaron Opoku Antwi et al.   MEDIATORS OF INFLAMMATION

Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma

(2017) Christopher Skappak et al.   PLoS One

Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation

(2017) Steven Maltby et al.   RESPIROLOGY

Inflammation and airway remodeling of the lung in guinea pigs with allergic rhinitis

(2017) Zu-Yao Chen et al.   Experimental and Therapeutic Medicine

Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma

(2017) Saeed Pazhoohan et al.   PLoS One

Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies

(2016) Maria G. Belvisi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pharmacodynamic evaluation of RP3128, a novel and potent CRAC channel inhibitor in guinea pig models of allergic asthma

(2016) Martina Sutovska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

(2016) Sara J. Bonvini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Welcome to the CRISPR zoo

(2016) Sara Reardon   NATURE

Mouse models of acute exacerbations of allergic asthma

(2016) Rakesh K. Kumar et al.   RESPIROLOGY

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

(2015) Peter W. West et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma

(2015) A P P Lowe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel concepts in airway inflammation and remodelling in asthma

(2015) Sejal Saglani et al.   EUROPEAN RESPIRATORY JOURNAL

Allergen-induced airway responses

(2015) Gail M. Gauvreau et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting TRP channels for chronic cough: from bench to bedside

(2015) Sara J. Bonvini et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma

(2015) Hao-yan Jiao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs

(2015) Alexander P.P. Lowe et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a novel, guinea pig-specific IFN-γ ELISPOT assay and characterization of guinea pig cytomegalovirus GP83-specific cellular immune responses following immunization with a modified vaccinia virus Ankara (MVA)-vectored GP83 vaccine

(2014) Peter A. Gillis et al.   VACCINE

Non-invasive measure of respiratory mechanics and conventional respiratory parameters in conscious large animals by high frequency Airwave Oscillometry

(2014) Leanne Bassett et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Antigen-induced mast cell expansion and bronchoconstriction in a mouse model of asthma

(2013) Shannon Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs

(2013) William R. Ford et al.   CLINICAL SCIENCE

Mast cell mediators cause early allergic bronchoconstriction in guinea-pigsin vivo: a model of relevance to asthma

(2013) Jason P. Riley et al.   CLINICAL SCIENCE

In vitro and ex vivo models of human asthma

(2013) Cornelia Blume et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs

(2013) Patricia Ramos-Ramírez et al.   EXPERIMENTAL LUNG RESEARCH

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation

(2012) Samantha Souza Possa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Development of the first oligonucleotide microarray for global gene expression profiling in guinea pigs: defining the transcription signature of infectious diseases

(2012) Ruchi Jain et al.   BMC GENOMICS

A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma

(2012) Rhys L. Evans et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Tools for cellular immunology and vaccine research the in the guinea pig: Monoclonal antibodies to cell surface antigens and cell lines

(2012) Hubert Schäfer et al.   VACCINE

Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways

(2012) Zhi-Hua Cui et al.   Clinical and Translational Allergy

Increased arginase activity contributes to airway remodelling in chronic allergic asthma

(2011) H. Maarsingh et al.   EUROPEAN RESPIRATORY JOURNAL

Inhaled nitric oxide aggravates phosgene model of acute lung injury

(2011) Wen-Li Li et al.   INHALATION TOXICOLOGY

RS-1748, a Novel CC Chemokine Receptor 4 Antagonist, Inhibits Ovalbumin-Induced Airway Inflammation in Guinea Pigs

(2010) Yasuhiro Nakagami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma

(2010) Shailaja G. Mahajan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β1-integrins shedding in a guinea-pig model of chronic asthma with remodelled airways

(2009) B. Bazán-Perkins et al.   CLINICAL AND EXPERIMENTAL ALLERGY

NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects

(2009) Miyuki Hori et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cooperation between Mast Cells and Neurons Is Essential for Antigen-Mediated Bronchoconstriction

(2009) J. M. Cyphert et al.   JOURNAL OF IMMUNOLOGY

Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

(2009) A. Gavalda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mast cell-cholinergic nerve interaction in mouse airways

(2009) Letitia A. Weigand et al.   JOURNAL OF PHYSIOLOGY-LONDON

Aerosolized Polymerized Type I Collagen Reduces Airway Inflammation and Remodelling in a Guinea Pig Model of Allergic Asthma

(2009) Paola Moreno-Alvarez et al.   LUNG

Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs

(2009) Akira Tokuda et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs

(2008) Hiroshi Tsuchida et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models

(2008) H. Meurs et al.   EUROPEAN RESPIRATORY JOURNAL

Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs

(2008) Adriane S. Nakashima et al.   JOURNAL OF APPLIED PHYSIOLOGY

The use of transgenic mice for modeling airways disease

(2008) Steven D. Shapiro   PULMONARY PHARMACOLOGY & THERAPEUTICS

Using guinea pigs in studies relevant to asthma and COPD

(2008) Brendan J. Canning et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effect of montelukast in a guinea pig model of cough variant asthma

(2007) Masaru Nishitsuji et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS