Mouse models of acute exacerbations of allergic asthma

Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma

(2015) Xiting Yan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Translational models of lung disease

(2015) Paul F. Mercer et al.   CLINICAL SCIENCE

Differential Effects of Particulate Matter Upwind and Downwind of an Urban Freeway in an Allergic Mouse Model

(2015) Marie A. McGee et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

ISU201 Enhances the Resolution of Airway Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

(2015) Yuka Hiroshima et al.   MEDIATORS OF INFLAMMATION

Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease

(2015) Alfred M. Del Vecchio et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations

(2014) G. Rohde et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33

(2014) A. M. Shadie et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Small Interfering RNAs Targeted to Interleukin-4 and Respiratory Syncytial Virus Reduce Airway Inflammation in a Mouse Model of Virus-Induced Asthma Exacerbation

(2014) Musa R. Khaitov et al.   HUMAN GENE THERAPY

Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

(2014) Robert J. Snelgrove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rhinovirus Exacerbates House-Dust-Mite Induced Lung Disease in Adult Mice

(2014) Jennifer A. Phan et al.   PLoS One

Anti-Inflammatory and Anti-Remodelling Effects of ISU201, a Modified Form of the Extracellular Domain of Human BST2, in Experimental Models of Asthma: Association with Inhibition of Histone Acetylation

(2014) Cristan Herbert et al.   PLoS One

Toll-Like Receptor Ligands LPS and Poly (I:C) Exacerbate Airway Hyperresponsiveness in a Model of Airway Allergy in Mice, Independently of Inflammation

(2014) Magnus Starkhammar et al.   PLoS One

Environmentally Determined Differences in the Murine Lung Microbiota and Their Relation to Alveolar Architecture

(2014) Yeojun Yun et al.   PLoS One

Aligning mouse models of asthma to human endotypes of disease

(2014) Rebecca A. Martin et al.   RESPIROLOGY

Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma

(2013) I. Mahmutovic-Persson et al.   ALLERGY

Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced asthma mouse model: consequences for steroid sensitivity

(2013) Hiroki Mori et al.   CLINICAL SCIENCE

Development of a mouse model mimicking key aspects of a viral asthma exacerbation

(2013) Deborah L. Clarke et al.   CLINICAL SCIENCE

No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model

(2013) Sabine Rochlitzer et al.   CLINICAL SCIENCE

Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma

(2013) Rylie P. Flesher et al.   CLINICAL SCIENCE

Preventive effect of galectin-9 on double-stranded RNA-induced airway hyperresponsiveness in an exacerbation model of mite antigen-induced asthma in mice

(2013) Shigeki Katoh et al.   EXPERIMENTAL LUNG RESEARCH

Elevated Macrophage Inflammatory Protein 1a and Interleukin-17 Production in an Experimental Asthma Model Infected with Respiratory Syncytial Virus

(2013) Taisei Ishioka et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Peripheral lung function in patients with stable and unstable asthma

(2013) Bruce R. Thompson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation

(2013) Stephanie Traub et al.   PLoS Pathogens

Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma

(2013) Melissa M. Bunting et al.   Biomed Research International

Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge

(2012) C. Herbert et al.   Disease Models & Mechanisms

Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma

(2012) Patricia Castellanos Penton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Lower Respiratory Tract Infection Induced by a Genetically Modified Picornavirus in Its Natural Murine Host

(2012) Louis A. Rosenthal et al.   PLoS One

Intranasal Administration of poly(I:C) and LPS in BALB/c Mice Induces Airway Hyperresponsiveness and Inflammation via Different Pathways

(2012) Magnus Starkhammar et al.   PLoS One

Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

(2012) Rakesh K. Kumar et al.   Frontiers in Physiology

Diesel Exhaust Particulates Exacerbate Asthma-Like Inflammation by Increasing CXC Chemokines

(2011) Jiyoun Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

Personal Exposures to Traffic-Related Air Pollution and Acute Respiratory Health among Bronx Schoolchildren with Asthma

(2011) Ariel Spira-Cohen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Asthma exacerbations: Origin, effect, and prevention

(2011) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Selection of rhinovirus 1A variants adapted for growth in mouse lung epithelial cells

(2011) Angela L. Rasmussen et al.   VIROLOGY

Alveolar Macrophages Stimulate Enhanced Cytokine Production by Pulmonary CD4+ T-Lymphocytes in an Exacerbation of Murine Chronic Asthma

(2010) Cristan Herbert et al.   AMERICAN JOURNAL OF PATHOLOGY

Association between human rhinovirus C and severity of acute asthma in children

(2010) J. Bizzintino et al.   EUROPEAN RESPIRATORY JOURNAL

The role of viruses in acute exacerbations of asthma

(2010) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

(2010) Jean Bousquet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages

(2010) D. R. Nagarkar et al.   JOURNAL OF IMMUNOLOGY

Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance

(2010) Christopher S. Stevenson et al.   PHARMACOLOGY & THERAPEUTICS

New therapies for asthma: is there any progress?

(2010) Peter J. Barnes   TRENDS IN PHARMACOLOGICAL SCIENCES

An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

(2009) Helen K. Reddel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathophysiological Features of Asthma Develop in Parallel in House Dust Mite–Exposed Neonatal Mice

(2009) Sejal Saglani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype

(2009) R. H. Dougherty et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Short-Term Effects of PM 10 and NO 2 on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis

(2009) Gudrun Weinmayr et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The outer wall of small airways is a major site of remodeling in fatal asthma

(2009) Marisa Dolhnikoff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Economic burden of asthma: a systematic review

(2009) Katayoun Bahadori et al.   BMC Pulmonary Medicine

Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice

(2008) S. Kierstein et al.   ALLERGY

Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

(2008) Kazuhiro Ito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The “Classical” Ovalbumin Challenge Model of Asthma in Mice

(2008) Rakesh Kumar et al.   CURRENT DRUG TARGETS

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE