Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway

Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

(2019) Dong Ryeol Ryu et al.   AGING CELL

Connexin 43: a New Therapeutic Target Against Chronic Kidney Disease

(2018) Niki Prakoura et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy

(2018) Zhiqiang Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells

(2017) Zhiquan Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury

(2017) Beom Jin Lim et al.   KIDNEY INTERNATIONAL

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Modelling diabetic nephropathy in mice

(2017) Kengo Azushima et al.   Nature Reviews Nephrology

The “tail” of Connexin43: An unexpected journey from alternative translation to trafficking

(2016) Wassim Basheer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer

(2016) Edward Leithe   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

(2016) Sander Lefere et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIF-1α regulates EMTviathe Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis

(2016) Yong Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats

(2016) Ou Zeng et al.   Bioengineered

Propofol Attenuated Acute Kidney Injury after Orthotopic Liver Transplantation via Inhibiting Gap Junction Composed of Connexin 32

(2015) Chenfang Luo et al.   ANESTHESIOLOGY

SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia

(2015) Hyun-Yoo Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AGEs-RAGE System Down-Regulates Sirt1 Through the Ubiquitin-Proteasome Pathway to Promote FN and TGF-β1 Expression in Male Rat Glomerular Mesangial Cells

(2015) Kai-Peng Huang et al.   ENDOCRINOLOGY

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

(2015) Brandon J. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In Vivo RNA Interference Models of Inducible and Reversible Sirt1 Knockdown in Kidney Cells

(2014) Peter Y. Chuang et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Transcription Factor Acetylation in Diabetic Kidney Disease

(2014) R. Liu et al.   DIABETES

RhoA/rho kinase signaling reduces connexin43 expression in high glucose-treated glomerular mesangial cells with zonula occludens-1 involvement

(2014) Xi Xie et al.   EXPERIMENTAL CELL RESEARCH

Connexin43 mediates NF-κB signalling activation induced by high glucose in GMCs: involvement of c-Src

(2013) Xi Xie et al.   Cell Communication and Signaling

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Inflammation and the pathogenesis of diabetic nephropathy

(2012) Jun Wada et al.   CLINICAL SCIENCE

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells

(2012) Yanggang Yuan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond

(2012) N Rohwer et al.   ONCOGENE

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy

(2011) Yashpal S. Kanwar et al.   Annual Review of Pathology-Mechanisms of Disease

Mammalian Sirt1: insights on its biological functions

(2011) Shahedur Rahman et al.   Cell Communication and Signaling

Hypoxia-inducible factor signaling in the development of tissue fibrosis

(2011) Debra F. Higgins et al.   CELL CYCLE

Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes

(2011) T. Takenaka et al.   DIABETOLOGIA

HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders

(2011) Hamid R. Rezvani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

(2011) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mouse Snail Is a Target Gene for HIF

(2011) D. Luo et al.   MOLECULAR CANCER RESEARCH

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

(2010) Kazuhiro Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt1 activation protects the mouse renal medulla from oxidative injury

(2010) Wenjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway

(2010) Qin Jiang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Epithelial–Mesenchymal Transition: From Molecular Mechanisms, Redox Regulation to Implications in Human Health and Disease

(2009) Stefania Cannito et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional Corepressor SMILE Recruits SIRT1 to Inhibit Nuclear Receptor Estrogen Receptor-related Receptor γ Transactivation

(2009) Yuan-Bin Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsic Epithelial Cells Repair the Kidney after Injury

(2008) Benjamin D. Humphreys et al.   Cell Stem Cell

From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy

(2008) Y. Qian et al.   DIABETES

Adhesive properties of connexin hemichannels

(2008) M. L. Cotrina et al.   GLIA

Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons

(2008) K. Hasegawa et al.   JOURNAL OF NEUROSCIENCE

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Function of connexins in the renal circulation

(2007) C. Wagner   KIDNEY INTERNATIONAL