Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2

(2020) Yunwen Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

(2018) Yunwen Yang et al.   CLINICAL SCIENCE

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation

(2018) Ran You et al.   Particle and Fibre Toxicology

Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells

(2018) Duy Trong Vien Diep et al.   Scientific Reports

Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

(2018) Xiao-Dong Li et al.   Drug Design Development and Therapy

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

(2017) Alexandra Zanin-Zhorov et al.   JOURNAL OF IMMUNOLOGY

Urine metabolomics insight into acute kidney injury point to oxidative stress disruptions in energy generation and H2S availability

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Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

(2017) Hui Peng et al.   Nature Communications

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

(2017) Zaniar Ghazizadeh et al.   Nature Communications

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE

(2016) Cristina Rozo et al.   ANNALS OF THE RHEUMATIC DISEASES

Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats

(2016) Junwei Fang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The global burden of chronic kidney disease: estimates, variability and pitfalls

(2016) Richard J. Glassock et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 5/6 Nephrectomy

(2016) Jing Yu et al.   Oxidative Medicine and Cellular Longevity

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction

(2015) ITSUKO BABA et al.   Molecular Medicine Reports

Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice

(2015) ITSUKO BABA et al.   Molecular Medicine Reports

ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration

(2015) Souska Zandi et al.   Cell Reports

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

(2015) Svenja Hartmann et al.   Frontiers in Pharmacology

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease

(2015) Shunsaku Nakagawa et al.   PLoS One

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

(2014) Alexandra Zanin-Zhorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Renal epithelial injury and fibrosis

(2013) Brigitte Kaissling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fasudil Inhibits Epithelial-Myofibroblast Transdifferentiation of Human Renal Tubular Epithelial HK-2 Cells Induced by High Glucose

(2013) Lingjia Gu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Rho-associated coiled-coil kinase (ROCK) signaling and disease

(2013) Alice V. Schofield et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Discovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile

(2013) Ran You et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epithelial Cell TGF  Signaling Induces Acute Tubular Injury and Interstitial Inflammation

(2013) M. E. Gentle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats

(2011) Tsung-Jung Ho et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells

(2010) Hideaki Shimada et al.   JOURNAL OF HEPATOLOGY

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

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Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS