Urine metabolomics insight into acute kidney injury point to oxidative stress disruptions in energy generation and H2S availability

Metabolomics for clinical use and research in chronic kidney disease

(2017) Berthold Hocher et al.   Nature Reviews Nephrology

Cytoskeleton deregulation and impairment in amino acids and energy metabolism in early atherosclerosis at aortic tissue with reflection in plasma

(2016) Marta Martin-Lorenzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury

(2016) Olga Ruiz-Andres et al.   KIDNEY INTERNATIONAL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Hypertensive patients exhibit an altered metabolism. A specific metabolite signature in urine is able to predict albuminuria progression

(2016) Laura Gonzalez-Calero et al.   Translational Research

Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis?

(2016) Laura Gonzalez-Calero et al.   Scientific Reports

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes

(2015) George J. Dugbartey et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biomarkers of drug-induced acute kidney injury in the adult

(2015) Glenda C Gobe et al.   Expert Opinion on Drug Metabolism & Toxicology

Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury

(2015) Sang Jun Han et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis

(2015) Zhi-Hao Zhang et al.   Scientific Reports

Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury

(2015) Seiji Kishi et al.   EBioMedicine

Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney

(2014) Teng Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute Kidney Injury After Coronary Artery Bypass Grafting and Long-Term Risk of End-Stage Renal Disease

(2014) Linda Rydén et al.   CIRCULATION

KLK1 and ZG16B proteins and arginine–proline metabolism identified as novel targets to monitor atherosclerosis, acute coronary syndrome and recovery

(2014) Marta Martin-Lorenzo et al.   Metabolomics

Acute kidney injury—epidemiology, outcomes and economics

(2014) Oleksa Rewa et al.   Nature Reviews Nephrology

Identification of a urine metabolomic signature in patients with advanced-stage chronic kidney disease

(2013) Maria Posada-Ayala et al.   KIDNEY INTERNATIONAL

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

TWEAK (tumor necrosis factor–like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation

(2012) María Concepción Izquierdo et al.   KIDNEY INTERNATIONAL

MetaboHunter: an automatic approach for identification of metabolites from 1H-NMR spectra of complex mixtures

(2011) Dan Tulpan et al.   BMC BIOINFORMATICS

Traditional Urinary Biomarkers in the Assessment of Hospital-Acquired AKI

(2011) M. A. Perazella et al.   Clinical Journal of the American Society of Nephrology

Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

(2011) F. M. van der Kloet et al.   Metabolomics

Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease

(2011) M. A. Aminzadeh et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

(2010) Jost Klawitter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

(2009) Steven G. Coca et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity

(2009) Kurt J. Boudonck et al.   TOXICOLOGIC PATHOLOGY

Long-Term Outcomes of Acute Kidney Injury

(2008) Ryan Goldberg et al.   ADVANCES IN CHRONIC KIDNEY DISEASE