Artificial Intelligence and Mechanistic Modeling for Clinical Decision Making in Oncology

International evaluation of an AI system for breast cancer screening

(2020) Scott Mayer McKinney et al.   NATURE

The Application of Deep Learning in Cancer Prognosis Prediction

(2020) Wan Zhu et al.   Cancers

SALMON: Survival Analysis Learning With Multi-Omics Neural Networks on Breast Cancer

(2019) Zhi Huang et al.   Frontiers in Genetics

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study

(2019) Jakob Nikolas Kather et al.   PLOS MEDICINE

Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas

(2019) David G. P. van IJzendoorn et al.   PLoS Computational Biology

Resistance models to EGFR inhibition and chemotherapy in non-small cell lung cancer via analysis of tumour size dynamics

(2019) Hitesh B. Mistry et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging

(2019) Yiwen Xu et al.   CLINICAL CANCER RESEARCH

Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma

(2019) Hao Peng et al.   CLINICAL CANCER RESEARCH

Association between tumor size kinetics and survival in urothelial carcinoma patients treated with atezolizumab: implication for patient's follow‐up

(2019) Coralie Tardivon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography

(2019) Diego Ardila et al.   NATURE MEDICINE

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

(2019) Jakob Nikolas Kather et al.   NATURE MEDICINE

Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting

(2019) Kari M. Morrissey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An augmented reality microscope with real-time artificial intelligence integration for cancer diagnosis

(2019) Po-Hsuan Cameron Chen et al.   NATURE MEDICINE

Pharmacometrics and Systems Pharmacology 2030

(2019) France Mentré et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Deep learning-based classification of mesothelioma improves prediction of patient outcome

(2019) Pierre Courtiol et al.   NATURE MEDICINE

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

(2019) Oleg Milberg et al.   Scientific Reports

Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer

(2019) M. Bilous et al.   Scientific Reports

Progress and Opportunities to Advance Clinical Cancer Therapeutics Using Tumor Dynamic Models

(2019) René Bruno et al.   CLINICAL CANCER RESEARCH

Deep Neural Networks Improve Radiologists’ Performance in Breast Cancer Screening

(2019) Nan Wu et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Watson for Oncology and breast cancer treatment recommendations: agreement with an expert multidisciplinary tumor board

(2018) S P Somashekhar et al.   ANNALS OF ONCOLOGY

Comparison of tumor size assessments in tumor growth inhibition-overall survival models with second-line colorectal cancer data from the VELOUR study

(2018) Laurent Claret et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity

(2018) Christophe Nioche et al.   CANCER RESEARCH

Visible Machine Learning for Biomedicine

(2018) Michael K. Yu et al.   CELL

Pembrolizumab exposure-response assessments challenged by association of cancer cachexia and catabolic clearance

(2018) David Turner et al.   CLINICAL CANCER RESEARCH

Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy

(2018) Benjamin Ribba et al.   CLINICAL CANCER RESEARCH

A Model of Overall Survival Predicts Treatment Outcomes with Atezolizumab versus Chemotherapy in Non–Small Cell Lung Cancer Based on Early Tumor Kinetics

(2018) Laurent Claret et al.   CLINICAL CANCER RESEARCH

Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients With Urothelial Carcinoma

(2018) Yanan Zheng et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status

(2018) Paul G. Baverel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Multivariate joint frailty model for the analysis of nonlinear tumor kinetics and dynamic predictions of death

(2018) Agnieszka Król et al.   STATISTICS IN MEDICINE

Cox-nnet: An artificial neural network method for prognosis prediction of high-throughput omics data

(2018) Travers Ching et al.   PLoS Computational Biology

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

(2018) Yuri Kosinsky et al.   Journal for ImmunoTherapy of Cancer

Assessment of nivolumab exposure and clinical safety of 480 mg every 4 weeks flat-dosing schedule in patients with cancer

(2018) G V Long et al.   ANNALS OF ONCOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

(2018) Ida Netterberg et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Time Is Money: Optimizing the Scheduling of Nivolumab

(2018) Mark J. Ratain et al.   JOURNAL OF CLINICAL ONCOLOGY

A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study

(2018) Roger Sun et al.   LANCET ONCOLOGY

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

(2018) Nicolas Coudray et al.   NATURE MEDICINE

Immunologically effective dose: a practical model for immunoradiotherapy

(2018) Raphaël Serre et al.   Oncotarget

Artificial Intelligence–Based Breast Cancer Nodal Metastasis Detection

(2018) Yun Liu et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

T2 -based MRI Delta-radiomics improve response prediction in soft-tissue sarcomas treated by neoadjuvant chemotherapy.

(2018) Amandine Crombé et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

High-performance medicine: the convergence of human and artificial intelligence

(2018) Eric J. Topol   NATURE MEDICINE

Vulnerabilities of radiomic signature development: The need for safeguards

(2018) Mattea L. Welch et al.   RADIOTHERAPY AND ONCOLOGY

Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study

(2018) Ahmed Hosny et al.   PLOS MEDICINE

Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall response

(2017) Hongshan Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: The LUNA16 challenge

(2017) Arnaud Arindra Adiyoso Setio et al.   MEDICAL IMAGE ANALYSIS

Dermatologist-level classification of skin cancer with deep neural networks

(2017) Andre Esteva et al.   NATURE

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision

(2017) Niklas Hartung et al.   PLoS One

Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer

(2017) Jingsong Zhang et al.   Nature Communications

Mathematical modeling for Phase I cancer trials: A study of metronomic vinorelbine for advanced non-small cell lung cancer (NSCLC) and mesothelioma patients

(2017) Fabrice Barlesi et al.   Oncotarget

Predicting clinical outcomes from large scale cancer genomic profiles with deep survival models

(2017) Safoora Yousefi et al.   Scientific Reports

Defining the biological basis of radiomic phenotypes in lung cancer

(2017) Patrick Grossmann et al.   eLife

Comparison of machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer from 18F-FDG PET/CT images

(2017) Hongkai Wang et al.   EJNMMI Research

A Deep Learning-Based Radiomics Model for Prediction of Survival in Glioblastoma Multiforme

(2017) Jiangwei Lao et al.   Scientific Reports

Bladder Cancer Treatment Response Assessment in CT using Radiomics with Deep-Learning

(2017) Kenny H. Cha et al.   Scientific Reports

Phase 1 study of twice weekly pulse dose and daily low-dose erlotinib as initial treatment for patients withEGFR-mutant lung cancers

(2016) H. A. Yu et al.   ANNALS OF ONCOLOGY

Revisiting dosing regimen using PK/PD modeling: the MODEL1 phase I/II trial of docetaxel plus epirubicin in metastatic breast cancer patients

(2016) Emilie Hénin et al.   BREAST CANCER RESEARCH AND TREATMENT

Mathematical Modeling of Cancer Immunotherapy and Its Synergy with Radiotherapy

(2016) R. Serre et al.   CANCER RESEARCH

Revisiting Dosing Regimen Using Pharmacokinetic/Pharmacodynamic Mathematical Modeling: Densification and Intensification of Combination Cancer Therapy

(2016) Christophe Meille et al.   CLINICAL PHARMACOKINETICS

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Brain Tumor Segmentation Using Convolutional Neural Networks in MRI Images

(2016) Sergio Pereira et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning

(2016) Hoo-Chang Shin et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer

(2016) Pedro M. Enriquez-Navas et al.   Science Translational Medicine

Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: a Comparison by Simulation of Two-Stage and Joint Approaches

(2015) Solène Desmée et al.   AAPS Journal

Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach

(2015) S. Benzekry et al.   CANCER RESEARCH

A “universal” model of metastatic cancer, its parametric forms and their identification: what can be learned from site-specific volumes of metastases

(2015) Leonid Hanin et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Deep learning

(2015) Yann LeCun et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Computational oncology — mathematical modelling of drug regimens for precision medicine

(2015) Dominique Barbolosi et al.   Nature Reviews Clinical Oncology

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma

(2015) Thibaud P. Coroller et al.   RADIOTHERAPY AND ONCOLOGY

Metronomic reloaded: Theoretical models bringing chemotherapy into the era of precision medicine

(2015) Sébastien Benzekry et al.   SEMINARS IN CANCER BIOLOGY

Machine learning applications in cancer prognosis and prediction

(2015) Konstantina Kourou et al.   Computational and Structural Biotechnology Journal

Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent

(2015) Noah Simon et al.   Journal of Statistical Software

Model-based clinical pharmacology profiling of ipilimumab in patients with advanced melanoma

(2014) Yan Feng et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Mathematical Modeling of Tumor Growth and Metastatic Spreading: Validation in Tumor-Bearing Mice

(2014) N. Hartung et al.   CANCER RESEARCH

Exposure-Response Relationships of the Efficacy and Safety of Ipilimumab in Patients with Advanced Melanoma

(2013) Y. Feng et al.   CLINICAL CANCER RESEARCH

The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository

(2013) Kenneth Clark et al.   JOURNAL OF DIGITAL IMAGING

Project Data Sphere to Make Cancer Clinical Trial Data Publicly Available

(2013) K. Hede   JNCI-Journal of the National Cancer Institute

Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies

(2012) Hiroshi Haeno et al.   CELL

A Tumor Growth Inhibition Model for Low-Grade Glioma Treated with Chemotherapy or Radiotherapy

(2012) B. Ribba et al.   CLINICAL CANCER RESEARCH

Radiomics: Extracting more information from medical images using advanced feature analysis

(2012) Philippe Lambin et al.   EUROPEAN JOURNAL OF CANCER

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling

(2011) J. Chmielecki et al.   Science Translational Medicine

Development and validation of a dynamic prognostic tool for prostate cancer recurrence using repeated measures of posttreatment PSA: a joint modeling approach

(2009) C. Proust-Lima et al.   BIOSTATISTICS

Adaptive Therapy

(2009) R. A. Gatenby et al.   CANCER RESEARCH

Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development

(2009) Y Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Model-Based Prediction of Phase III Overall Survival in Colorectal Cancer on the Basis of Phase II Tumor Dynamics

(2009) Laurent Claret et al.   JOURNAL OF CLINICAL ONCOLOGY

A change of strategy in the war on cancer

(2009) Robert A. Gatenby   NATURE

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies

(2009) Jasmine Foo et al.   PLoS Computational Biology

A Pharmacodynamic Model for the Time Course of Tumor Shrinkage by Gemcitabine + Carboplatin in Non-Small Cell Lung Cancer Patients

(2008) L.-S. Tham et al.   CLINICAL CANCER RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

(2008) Kerby Shedden et al.   NATURE MEDICINE

Tumor Growth Rates Derived from Data for Patients in a Clinical Trial Correlate Strongly with Patient Survival: A Novel Strategy for Evaluation of Clinical Trial Data

(2008) W. D. Stein et al.   ONCOLOGIST