Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties

S100A12 Expression Is Modulated During Monocyte Differentiation and Reflects Periodontitis Severity

(2020) Ronaldo Lira-Junior et al.   Frontiers in Immunology

Disruption of Monocyte and Macrophage Homeostasis in Periodontitis

(2020) Abdulrahman Almubarak et al.   Frontiers in Immunology

Diabetes as a risk factor for periodontal disease—plausible mechanisms

(2020) David Polak et al.   PERIODONTOLOGY 2000

An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis

(2019) X. Wu et al.   JOURNAL OF DENTAL RESEARCH

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing

(2019) Pijus K. Barman et al.   JOURNAL OF PATHOLOGY

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

(2019) Siyuan Chen et al.   Cellular & Molecular Immunology

Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation

(2019) Tessa J. Barrett et al.   CIRCULATION

The impact of diabetes on periodontal diseases

(2019) Dana T. Graves et al.   PERIODONTOLOGY 2000

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chemokines: the past, the present and the future

(2018) Peng Tang et al.   Cellular & Molecular Immunology

Chemokines in homeostasis and diseases

(2018) Keqiang Chen et al.   Cellular & Molecular Immunology

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice

(2018) Xidi Yuan et al.   JOURNAL OF NEUROSCIENCE

Host defense against oral microbiota by bone-damaging T cells

(2018) Masayuki Tsukasaki et al.   Nature Communications

Tooth loss in periodontally compromised patients: results 20 years after active periodontal therapy

(2018) Bernadette Pretzl et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge

(2018) Thomas Kocher et al.   PERIODONTOLOGY 2000

Developmental and Functional Heterogeneity of Monocytes

(2018) Martin Guilliams et al.   IMMUNITY

Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models

(2018) Z. Zhuang et al.   JOURNAL OF DENTAL RESEARCH

Periodontal diseases

(2017) Denis F. Kinane et al.   Nature Reviews Disease Primers

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Impact of Nurse-Led, Multidisciplinary Home-Based Intervention on Event-Free Survival Across the Spectrum of Chronic Heart DiseaseCLINICAL PERSPECTIVE

(2016) Simon Stewart et al.   CIRCULATION

Co-culture of bone marrow stem cells and macrophages indicates intermediate mechanism between local inflammation and innate immune system in diabetic periodontitis

(2016) Jia Wang et al.   Experimental and Therapeutic Medicine

Effects of TNF-αblocking on experimental periodontitis and type 2 diabetes in obese diabetic Zucker rats

(2015) Morten Bay Grauballe et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Activation and resolution of periodontal inflammation and its systemic impact

(2015) Hatice Hasturk et al.   PERIODONTOLOGY 2000

Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B

(2015) Sandra Pacios et al.   Scientific Reports

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Metabolic Syndrome Exacerbates Inflammation and Bone Loss in Periodontitis

(2014) Y. Li et al.   JOURNAL OF DENTAL RESEARCH

Characterization of Conventional and Atypical Receptors for the Chemokine CCL2 on Mouse Leukocytes

(2014) L. B. Ford et al.   JOURNAL OF IMMUNOLOGY

Macrophage Depletion AbatesPorphyromonas gingivalis–Induced Alveolar Bone Resorption in Mice

(2014) Roselind S. Lam et al.   JOURNAL OF IMMUNOLOGY

Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic biomarker in the pathogenesis of chronic periodontal disease

(2013) Mili Gupta et al.   CYTOKINE

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

(2013) George Hajishengallis   TRENDS IN IMMUNOLOGY

Bindarit

(2012) Eugenio Mora et al.   CELL CYCLE

Periodontitis and diabetes: a two-way relationship

(2011) P. M. Preshaw et al.   DIABETOLOGIA

Diabetes aggravates periodontitis by limiting repair through enhanced inflammation

(2011) Sandra Pacios et al.   FASEB JOURNAL

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

(2011) Evanthia Lalla et al.   Nature Reviews Endocrinology

Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy

(2011) Kangkai Wang et al.   Journal of Molecular Cell Biology

Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP

(2010) Craig W. Younce et al.   CARDIOVASCULAR RESEARCH

The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice

(2009) G. Grassia et al.   CARDIOVASCULAR RESEARCH

Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease

(2009) A.R. Pradeep et al.   CYTOKINE

Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis

(2009) Nikolaus B Binder et al.   NATURE MEDICINE