Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions

The Innate Biologies of Adaptive Antigen Receptors

(2020) Adrian C. Hayday et al.   Annual Review of Immunology

Recognition of synthetic polyanionic ligands underlies “spontaneous” reactivity of Vγ1 γδTCRs

(2020) Josefine Dunst et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset

(2020) Alina S. Fichtner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

Human γδ TCR Repertoires in Health and Disease

(2020) Alina Suzann Fichtner et al.   Cells

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

(2019) Benjamin E. Willcox et al.   NATURE IMMUNOLOGY

Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors

(2019) Jan Kisielow et al.   NATURE IMMUNOLOGY

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

Detection of Cell Surface Ligands for Human Synovial γδ T Cells

(2019) Cheryl Collins et al.   JOURNAL OF IMMUNOLOGY

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

(2019) Zsolt Sebestyen et al.   NATURE REVIEWS DRUG DISCOVERY

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

Activation of TCR Vδ1+ and Vδ1−Vδ2− γδ T Cells upon Controlled Infection with Plasmodium falciparum in Tanzanian Volunteers

(2019) Tobias Rutishauser et al.   JOURNAL OF IMMUNOLOGY

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

(2019) Ahmed Gaballa et al.   Stem Cells International

A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

(2018) Murad R. Mamedov et al.   IMMUNITY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of a selecting ligand in shaping the murine γδ-TCR repertoire

(2018) Shawn P. Fahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γδ T cell responses: How many ligands will it take till we know?

(2018) David Vermijlen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recasting Human Vδ1 Lymphocytes in an Adaptive Role

(2018) Martin S. Davey et al.   TRENDS IN IMMUNOLOGY

Vδ2+ T Cells—Two Subsets for the Price of One

(2018) Martin S. Davey et al.   Frontiers in Immunology

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

(2017) Khiem Nguyen et al.   FASEB JOURNAL

The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells

(2017) Cassie-Marie Peigné et al.   JOURNAL OF IMMUNOLOGY

Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

(2017) Romain Marlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Regulation of Immunity by Butyrophilins

(2016) David A. Rhodes et al.   Annual Review of Immunology

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection

(2016) Mahboob Salim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

(2016) Sobhan Roy et al.   JOURNAL OF IMMUNOLOGY

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

(2016) Zsolt Sebestyen et al.   Cell Reports

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

(2015) Mateusz Legut et al.   Cellular & Molecular Immunology

Early innate responses to pathogens: pattern recognition by unconventional human T-cells

(2015) Anna Rita Liuzzi et al.   CURRENT OPINION IN IMMUNOLOGY

Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

(2015) Hong Wang et al.   JOURNAL OF IMMUNOLOGY

Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin

(2015) David A. Rhodes et al.   JOURNAL OF IMMUNOLOGY

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6

(2014) Felipe Riaño et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos)

(2014) Mohindar M. Karunakaran et al.   IMMUNOGENETICS

Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide–MHC Demonstrates Absence of TCR–Peptide Contacts

(2014) Karin E. J. Rödström et al.   JOURNAL OF IMMUNOLOGY

γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation

(2014) M. Kemal Aydintug et al.   MOLECULAR IMMUNOLOGY

Gamma delta T cells recognize haptens and mount a hapten-specific response

(2014) Xun Zeng et al.   eLife

Identification of a New Tuberculosis Antigen Recognized by γδ T Cell Receptor

(2013) Xueyan Xi et al.   Clinical and Vaccine Immunology

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

(2013) W Scheper et al.   LEUKEMIA

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

γδ T-cell conference 2012: Close encounters for the fifth time

(2012) Bruno Silva-Santos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response

(2012) Xun Zeng et al.   IMMUNITY

The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies

(2012) Aparna Palakodeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity

(2012) Yumei Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis

(2012) Jessica Bruder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Harnessing γδ T cells in anticancer immunotherapy

(2012) Dalil Hannani et al.   TRENDS IN IMMUNOLOGY

Searching for “signal 2”: costimulation requirements of γδ T cells

(2011) Julie C. Ribot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted    T Cells in the Normal Murine Repertoire

(2011) M. Dieude et al.   JOURNAL OF IMMUNOLOGY

A Novel Strategy to Screen Bacillus Calmette-Guérin Protein Antigen Recognized by γδ TCR

(2011) XueYan Xi et al.   PLoS One

Evolution of the V, D, and J gene segments used in the primate    T-cell receptor reveals a dichotomy of conservation and diversity

(2011) A. R. Kazen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes

(2010) Ana deBarros et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23

(2010) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

NKG2D Costimulates Human V 9V 2 T Cell Antitumor Cytotoxicity through Protein Kinase C -Dependent Modulation of Early TCR-Induced Calcium and Transduction Signals

(2010) S. Nedellec et al.   JOURNAL OF IMMUNOLOGY

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial    T Cell Activation

(2010) D. A. Witherden et al.   SCIENCE

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS