γδ TCR ligands: the quest to solve a 500-million-year-old mystery

A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

(2018) Murad R. Mamedov et al.   IMMUNITY

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

(2018) Stuart Hunter et al.   JOURNAL OF HEPATOLOGY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrophilin3A proteins and Vγ9Vδ2 T cell activation

(2018) Siyi Gu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recasting Human Vδ1 Lymphocytes in an Adaptive Role

(2018) Martin S. Davey et al.   TRENDS IN IMMUNOLOGY

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

Lymph node γδ and αβ CD8+ T cells share migratory properties

(2018) Milas Ugur et al.   Scientific Reports

Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire

(2018) Carrie R. Willcox et al.   Frontiers in Immunology

Vδ2+ T Cells—Two Subsets for the Price of One

(2018) Martin S. Davey et al.   Frontiers in Immunology

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

(2017) Romain Marlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

γδ T Cell-Mediated Immunity to Cytomegalovirus Infection

(2017) Camille Khairallah et al.   Frontiers in Immunology

Regulation of Immunity by Butyrophilins

(2016) David A. Rhodes et al.   Annual Review of Immunology

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection

(2016) Mahboob Salim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

(2016) Sobhan Roy et al.   JOURNAL OF IMMUNOLOGY

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

(2016) Peter Jönsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chicago 2014 – 30years of γδ T cells

(2015) Marc Bonneville et al.   CELLULAR IMMUNOLOGY

Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

(2015) Hong Wang et al.   JOURNAL OF IMMUNOLOGY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

(2015) Camille Khairallah et al.   PLoS Pathogens

Control of Murine Cytomegalovirus Infection by γδ T Cells

(2015) Sabrina Sell et al.   PLoS Pathogens

Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6

(2014) Felipe Riaño et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Human    Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

(2014) J. C. Ribot et al.   JOURNAL OF IMMUNOLOGY

γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation

(2014) M. Kemal Aydintug et al.   MOLECULAR IMMUNOLOGY

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Evolutionary implications of a third lymphocyte lineage in lampreys

(2013) Masayuki Hirano et al.   NATURE

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic

(2012) Shirin Kalyan et al.   Cellular & Molecular Immunology

γδ T-cell conference 2012: Close encounters for the fifth time

(2012) Bruno Silva-Santos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR

(2012) Li Bai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response

(2012) Xun Zeng et al.   IMMUNITY

The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies

(2012) Aparna Palakodeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis

(2012) Jessica Bruder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Body-barrier surveillance by epidermal γδ TCRs

(2012) Grzegorz Chodaczek et al.   NATURE IMMUNOLOGY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting    T Lymphocytes for Cancer Immunotherapy: From Novel Mechanistic Insight to Clinical Application

(2010) A. Q. Gomes et al.   CANCER RESEARCH

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

Identification of Human T Cell Receptor γδ-recognized Epitopes/Proteins via CDR3δ Peptide-based Immunobiochemical Strategy

(2008) Hui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY