RZZ-SPINDLY-DYNEIN: you got to keep ‘em separated

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells

(2020) Amanda J. Broad et al.   JOURNAL OF CELL BIOLOGY

Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis

(2020) Michael A. Hadders et al.   JOURNAL OF CELL BIOLOGY

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

(2019) Yuejia Huang et al.   CELL RESEARCH

The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells

(2019) Anne-Laure Pauleau et al.   PLoS Genetics

Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments

(2019) João Barbosa et al.   EMBO JOURNAL

The Opposing Functions of Protein Kinases and Phosphatases in Chromosome Bipolar Attachment

(2019) Delaney Sherwin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kinetochore assembly and disassembly during mitotic entry and exit

(2018) Masatoshi Hara et al.   CURRENT OPINION IN CELL BIOLOGY

Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore–microtubule attachments during mitosis

(2018) Mohammed A. Amin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

(2018) Damian Dudka et al.   Nature Communications

Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment

(2018) Go Itoh et al.   Scientific Reports

Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism

(2018) Shivangi Agarwal et al.   JOURNAL OF CELL BIOLOGY

The kinetochore–microtubule interface at a glance

(2018) Julie K. Monda et al.   JOURNAL OF CELL SCIENCE

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

(2018) Marion E. Pesenti et al.   MOLECULAR CELL

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

(2018) Tae Yeon Yoo et al.   eLife

Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion

(2018) Jose-Antonio Rodriguez-Rodriguez et al.   CURRENT BIOLOGY

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment

(2018) Cláudia Pereira et al.   CURRENT BIOLOGY

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Structure of the RZZ complex and molecular basis of its interaction with Spindly

(2017) Shyamal Mosalaganti et al.   JOURNAL OF CELL BIOLOGY

Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells

(2017) Roshan L. Shrestha et al.   Nature Communications

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

(2017) Ana Maria G Dumitru et al.   eLife

Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

(2016) Robert F Lera et al.   Nature Chemical Biology

Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding

(2016) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1·CENP-Q Complex from Kinetochores

(2015) Chi Hoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores

(2015) Devinderjit K. Moudgil et al.   JOURNAL OF CELL BIOLOGY

Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules

(2015) Anatoly V. Zaytsev et al.   MOLECULAR BIOLOGY OF THE CELL

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

(2015) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity

(2015) Anatoly V. Zaytsev et al.   MOLECULAR BIOLOGY OF THE CELL

Kinetochore–microtubule error correction is driven by differentially regulated interaction modes

(2015) Maria Kalantzaki et al.   NATURE CELL BIOLOGY

Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

(2015) Valentin Magidson et al.   NATURE CELL BIOLOGY

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

(2015) Gang Zhang et al.   Nature Communications

Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes

(2015) Danica Drpic et al.   Cell Reports

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status

(2014) Daniel R. Matson et al.   JOURNAL OF CELL BIOLOGY

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces

(2014) Marin Barisic et al.   NATURE CELL BIOLOGY

Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster

(2014) M. Carmena et al.   Open Biology

Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK

(2013) Roshan L. Shrestha et al.   CURRENT BIOLOGY

Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation

(2013) Carlos Conde et al.   EMBO JOURNAL

Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores

(2013) Dileep Varma et al.   JOURNAL OF CELL BIOLOGY

Elevated polar ejection forces stabilize kinetochore–microtubule attachments

(2013) Stuart Cane et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

(2013) Lilian Kabeche et al.   NATURE

Ubiquitylation-dependent localization of PLK1 in mitosis

(2013) Jochen Beck et al.   NATURE CELL BIOLOGY

Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation

(2013) D. K. Cheerambathur et al.   SCIENCE

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

(2013) P. Xu et al.   Biology Open

A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression

(2012) Catherine Randall Paschal et al.   CHROMOSOMA

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Polo-like kinase-1 regulates kinetochore–microtubule dynamics and spindle checkpoint silencing

(2012) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments

(2012) T. Moutinho-Santos et al.   JOURNAL OF CELL SCIENCE

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation

(2012) Emily A. Hood et al.   MOLECULAR BIOLOGY OF THE CELL

The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly

(2011) Valentin Magidson et al.   CELL

Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase

(2011) Kevan J. Salimian et al.   CURRENT BIOLOGY

Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores

(2011) Young H. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores

(2011) James M. Kasuboski et al.   MOLECULAR BIOLOGY OF THE CELL

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetochore–microtubule interactions: steps towards bi-orientation

(2010) Tomoyuki U Tanaka   EMBO JOURNAL

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

(2010) Marin Barisic et al.   MOLECULAR BIOLOGY OF THE CELL

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Structural Analysis of the RZZ Complex Reveals Common Ancestry with Multisubunit Vesicle Tethering Machinery

(2010) Filiz Çivril et al.   STRUCTURE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

(2009) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex

(2008) R. Gassmann et al.   GENES & DEVELOPMENT

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

(2008) Jacqueline Whyte et al.   JOURNAL OF CELL BIOLOGY

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint

(2008) Jakub K. Famulski et al.   JOURNAL OF CELL BIOLOGY

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY