Tumor microenvironment in gastric cancers

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

GPR30-expressing Gastric Chief Cells do not Dedifferentiate but are Eliminated via PDK-dependent Cell Competition During Development of Metaplasia

(2020) Masahiro Hata et al.   GASTROENTEROLOGY

Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis

(2020) Wenju Chang et al.   Cell Stem Cell

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

(2019) Jiang Lv et al.   Journal of Hematology & Oncology

R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach

(2019) Michael Sigal et al.   NATURE CELL BIOLOGY

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

(2019) Mohammed Soutto et al.   Nature Communications

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

(2019) Moritz F. Eissmann et al.   Nature Communications

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

(2019) Yasuyuki Mizutani et al.   CANCER RESEARCH

The CXCL12-CXCR4 signaling axis plays a key role in cancer metastasis and is a potential target for developing novel therapeutics against metastatic cancer

(2019) Ping Yang et al.   CURRENT MEDICINAL CHEMISTRY

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

(2019) F. Zhang et al.   Nature Communications

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

(2019) Haisheng Zhang et al.   Cancer Discovery

Role of the Microenvironment in Gastrointestinal Tumors

(2019) Nathaniel Weygant et al.   Journal of Oncology

Mature gastric chief cells are not required for the development of metaplasia

(2018) Hiroto Kinoshita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment

(2018) Qi Zhao et al.   CANCER RESEARCH

IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment

(2018) Tatiana A Karakasheva et al.   CANCER RESEARCH

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

(2018) Lorraine A. O’Reilly et al.   IMMUNITY

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

(2018) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

Three types of metaplasia models through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium

(2018) Hiroto Kinoshita et al.   JOURNAL OF PATHOLOGY

Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion

(2018) Rui Wang et al.   MOLECULAR CANCER RESEARCH

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

(2018) Bernhard W Renz et al.   Cancer Discovery

BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice

(2018) Yoku Hayakawa et al.   GASTROENTEROLOGY

Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ

(2018) Tatyana Veremeyko et al.   Frontiers in Immunology

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

(2017) Takatsugu Ishimoto et al.   GASTROENTEROLOGY

Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment forHelicobacter pylori: a retrospective cohort analysis

(2017) Ryota Niikura et al.   GUT

A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach

(2017) Christine P Petersen et al.   GUT

Cancer-associated fibroblast-derived Lumican promotes gastric cancer progression via the integrin β1-FAK signaling pathway

(2017) Xiaofeng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Metaplasia in the Stomach—Precursor of Gastric Cancer?

(2017) Hiroto Kinoshita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

(2017) Michael Sigal et al.   NATURE

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

(2017) Hayato Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nerves switch on angiogenic metabolism

(2017) Yoku Hayakawa et al.   SCIENCE

Predictive relevance of PD-L1 expression with pre-existing TILs in gastric cancer

(2017) Xiaoli Ju et al.   Oncotarget

CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development

(2017) Kosuke Sakitani et al.   Oncotarget

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway

(2017) Xiongyan Wu et al.   Oncotarget

Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells - TREAT-ME-1 - a phase I, first in human, first in class trial

(2017) Jobst C. von Einem et al.   Oncotarget

Cancer-associated fibroblasts in digestive tumors

(2017) Lei Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Vagotomy and Gastric Tumorigenesis

(2016) Hanne-Line Rabben et al.   Current Neuropharmacology

Gastrin and upper GI cancers

(2016) Yoku Hayakawa et al.   CURRENT OPINION IN PHARMACOLOGY

M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T-cell proliferation

(2016) Shinji Oishi et al.   IMMUNOLOGY

Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth

(2016) Gang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR regulates macrophage activation and function in bacterial infection

(2016) Dana M. Hardbower et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

(2016) Zina Dubeykovskaya et al.   Nature Communications

Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett’s-like esophagus

(2016) Yoomi Lee et al.   Oncotarget

Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer

(2015) Mao Watanabe Tokumoto et al.   BRITISH JOURNAL OF CANCER

Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

(2015) Yoku Hayakawa et al.   CANCER CELL

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

(2015) Pu Li et al.   CELL RESEARCH

Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination

(2015) Takahisa Yamaguchi et al.   Gastric Cancer

Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling

(2015) Takako Serizawa et al.   INFECTION AND IMMUNITY

RhoA Mutations Identified in Diffuse Gastric Cancer

(2014) Jin Zhou et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia After Acute Loss of Parietal Cells

(2014) Christine P. Petersen et al.   GASTROENTEROLOGY

CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis

(2014) Yoku Hayakawa et al.   GUT

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity

(2014) Ingunn M Stromnes et al.   GUT

Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

(2014) Keunwook Lee et al.   Gut and Liver

Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information

(2014) Mireia Berdiel-Acer et al.   Molecular Oncology

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization

(2014) M S Krakowiak et al.   ONCOGENE

Denervation suppresses gastric tumorigenesis

(2014) C.-M. Zhao et al.   Science Translational Medicine

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Role of the tumor microenvironment in the pathogenesis of gastric carcinoma

(2014) Hye Won Chung   WORLD JOURNAL OF GASTROENTEROLOGY

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Obesity acceleratesHelicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response

(2013) Russell E Ericksen et al.   GUT

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signaling

(2013) Tsuyoshi Hasegawa et al.   INTERNATIONAL JOURNAL OF CANCER

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Interleukin-6 Mediates Epithelial–Stromal Interactions and Promotes Gastric Tumorigenesis

(2013) Hiroto Kinoshita et al.   PLoS One

Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases

(2013) M. Gil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse Models of Gastric Cancer

(2013) Yoku Hayakawa et al.   Cancers

T Cells in Gastric Cancer: Friends or Foes

(2012) Amedeo Amedei et al.   Clinical & Developmental Immunology

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

(2012) Samuel Asfaha et al.   GASTROENTEROLOGY

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors

(2012) Wataru Shibata et al.   GUT

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia

(2010) T. Okumura et al.   CANCER RESEARCH

Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing

(2010) Hiroyuki Tomita et al.   GASTROENTEROLOGY

Prostaglandin E2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors

(2010) Hiroko Oshima et al.   GASTROENTEROLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Gastrin Is an Essential Cofactor for Helicobacter- Associated Gastric Corpus Carcinogenesis in C57BL/6 Mice

(2009) Shigeo Takaishi et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

(2008) Keisuke Oguma et al.   EMBO JOURNAL

Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice

(2008) M. Kaparakis et al.   INFECTION AND IMMUNITY