Mouse Models of Gastric Cancer

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

(2012) Samuel Asfaha et al.   GASTROENTEROLOGY

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors

(2012) Wataru Shibata et al.   GUT

Topical application of acetic acid in cytoreduction of gastric cancer. A technical report using mouse model

(2012) Susumu Okabe et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse

(2012) Melanie J. Thomson et al.   PLoS One

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

17 -Estradiol and Tamoxifen Prevent Gastric Cancer by Modulating Leukocyte Recruitment and Oncogenic Pathways in Helicobacter Pylori-Infected INS-GAS Male Mice

(2011) A. Sheh et al.   Cancer Prevention Research

IFN-  Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis

(2011) S. P. Tu et al.   CANCER RESEARCH

17 -Estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice

(2011) M. Ohtani et al.   CARCINOGENESIS

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Loss of Runx3 Is a Key Event in Inducing Precancerous State of the Stomach

(2011) Kosei Ito et al.   GASTROENTEROLOGY

Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice

(2011) Qiang Li et al.   GASTROENTEROLOGY

Helicobacter pylori Infection Recruits Bone Marrow−Derived Cells That Participate in Gastric Preneoplasia in Mice

(2011) Christine Varon et al.   GASTROENTEROLOGY

Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

(2011) Shu Shimada et al.   GUT

Coinfection with Enterohepatic Helicobacter Species Can Ameliorate or Promote Helicobacter pylori-Induced Gastric Pathology in C57BL/6 Mice

(2011) Zhongming Ge et al.   INFECTION AND IMMUNITY

Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice

(2011) Jennifer Nancy Hahn et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of TFF1 is associated with activation of NF-κB–mediated inflammation and gastric neoplasia in mice and humans

(2011) Mohammed Soutto et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling in stomach epithelial stem cell homeostasis

(2011) Tae-Hee Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

(2011) Yongyong Shi et al.   NATURE GENETICS

Epithelial Tissues Have Varying Degrees of Susceptibility to KrasG12D-Initiated Tumorigenesis in a Mouse Model

(2011) Kevin C. Ray et al.   PLoS One

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia

(2010) T. Okumura et al.   CANCER RESEARCH

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

TFF2 mRNA Transcript Expression Marks a Gland Progenitor Cell of the Gastric Oxyntic Mucosa

(2010) Michael Quante et al.   GASTROENTEROLOGY

Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

(2010) Anthony J. Peterson et al.   GASTROENTEROLOGY

Inhibitor of κB Kinase Beta Regulates Gastric Carcinogenesis via Interleukin-1α Expression

(2010) Kei Sakamoto et al.   GASTROENTEROLOGY

Spasmolytic Polypeptide-Expressing Metaplasia and Intestinal Metaplasia: Time for Reevaluation of Metaplasias and the Origins of Gastric Cancer

(2010) James R. Goldenring et al.   GASTROENTEROLOGY

Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach

(2010) Ki Taek Nam et al.   GASTROENTEROLOGY

Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing

(2010) Hiroyuki Tomita et al.   GASTROENTEROLOGY

Tolerance Rather Than Immunity Protects From Helicobacter pylori–Induced Gastric Preneoplasia

(2010) Isabelle C. Arnold et al.   GASTROENTEROLOGY

Lack of Commensal Flora in Helicobacter pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia

(2010) Jennifer L. Lofgren et al.   GASTROENTEROLOGY

Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7

(2010) Y. Yin et al.   GUT

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

(2010) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

(2010) Christian C Abnet et al.   NATURE GENETICS

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection

(2010) A. Sheh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

(2010) Y. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastrin Is an Essential Cofactor for Helicobacter- Associated Gastric Corpus Carcinogenesis in C57BL/6 Mice

(2009) Shigeo Takaishi et al.   AMERICAN JOURNAL OF PATHOLOGY

E-Cadherin Deficiency Initiates Gastric Signet-Ring Cell Carcinoma in Mice and Man

(2009) B. Humar et al.   CANCER RESEARCH

Combination of Sulindac and Antimicrobial Eradication of Helicobacter pylori Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice

(2009) C.-W. Lee et al.   CANCER RESEARCH

Interleukin-1β Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog

(2009) Meghna Waghray et al.   GASTROENTEROLOGY

Loss of Parietal Cell Expression of Sonic Hedgehog Induces Hypergastrinemia and Hyperproliferation of Surface Mucous Cells

(2009) Chang Xiao et al.   GASTROENTEROLOGY

Conditional Deletion of IκB-Kinase-β Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia

(2009) Wataru Shibata et al.   GASTROENTEROLOGY

Concurrent Helicobacter bilis Infection in C57BL/6 Mice Attenuates Proinflammatory H. pylori-Induced Gastric Pathology

(2009) L. B. Lemke et al.   INFECTION AND IMMUNITY

The CD4+ T Cell-Mediated IFN-  Response to Helicobacter Infection Is Essential for Clearance and Determines Gastric Cancer Risk

(2009) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44

(2009) Shigeo Takaishi et al.   STEM CELLS

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

Helicobacter pylori Eradication Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice

(2008) C.-W. Lee et al.   CANCER RESEARCH

c-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice

(2008) W. Shibata et al.   CANCER RESEARCH

Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis inN-methyl-N-nitrosourea-treated K19-C2mE transgenic mice

(2008) Shinji Takasu et al.   CANCER SCIENCE

Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice

(2008) Wai K. Leung et al.   CARCINOGENESIS

Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner

(2008) Emer P. Reeves et al.   GASTROENTEROLOGY

Syndromic Colon Cancer: Lynch Syndrome and Familial Adenomatous Polyposis

(2008) Tusar K. Desai et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression

(2008) Louise M Judd et al.   JOURNAL OF PATHOLOGY

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

(2008) Hiromi Sakamoto et al.   NATURE GENETICS

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis

(2007) S.M.C. Przemeck et al.   REGULATORY PEPTIDES