Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease

Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

(2017) Michelle T. Fodero-Tavoletti et al.   JOURNAL OF ALZHEIMERS DISEASE

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer’s Disease

(2013) Vijaya B. Kenche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The therapeutics of Alzheimer's disease: Where we stand and where we are heading

(2013) Dennis J. Selkoe   ANNALS OF NEUROLOGY

Design, synthesis and structure–activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

(2013) Jinhe Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide

(2013) Victor A. Streltsov et al.   CHEMICAL COMMUNICATIONS

Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

(2013) Fabrice Collin et al.   CHEMICAL COMMUNICATIONS

Clawing back: broadening the notion of metal chelators in medicine

(2013) Katherine J Franz   CURRENT OPINION IN CHEMICAL BIOLOGY

99mTc-labeled dibenzylideneacetone derivatives as potential SPECT probes for in vivo imaging of β-amyloid plaque

(2013) Yanping Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications

(2013) Yuzhong Liu et al.   INORGANIC CHEMISTRY

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Synthesis and Characterization of fac-[M(CO)3(P)(OO)] and cis-trans-[M(CO)2(P)2(OO)] Complexes (M = Re, 99mTc) with Acetylacetone and Curcumin as OO Donor Bidentate Ligands

(2013) Charalampos Triantis et al.   INORGANIC CHEMISTRY

Inhibition of human prion neuropeptide PrP106-126 aggregation by hexacoordinated ruthenium complexes

(2013) Xuesong Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Positron emission tomography radioligands forin vivoimaging of Aβplaques

(2013) N. Scott Mason et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Head-to-Head Comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for  -Amyloid Imaging in Aging and Dementia

(2013) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Diagnostic Imaging Agents for Alzheimer’s Disease: Copper Radiopharmaceuticals that Target Aβ Plaques

(2013) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unraveling the Photoluminescence Response of Light-Switching Ruthenium(II) Complexes Bound to Amyloid-β

(2013) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of a Common Binding Mode for Imaging Agents to Amyloid Fibrils from Molecular Dynamics Simulations

(2013) Katrine Kirkeby Skeby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation

(2013) Lei He et al.   Metallomics

PtCl2(phen) disrupts the metal ions binding to amyloid-β peptide

(2013) Guolin Ma et al.   Metallomics

Brain  -amyloid load approaches a plateau

(2013) C. R. Jack et al.   NEUROLOGY

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

(2013) Luigi Messori et al.   ACS Medicinal Chemistry Letters

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Therapeutic Redistribution of Metal Ions To Treat Alzheimer’s Disease

(2012) Peter J. Crouch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain

(2012) Xuedan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Werner coordination chemistry and neurodegeneration

(2012) Maria A. Telpoukhovskaia et al.   CHEMICAL SOCIETY REVIEWS

Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)

(2012) Izabela Zawisza et al.   COORDINATION CHEMISTRY REVIEWS

Diagnostic imaging of Alzheimer's disease with copper and technetium complexes

(2012) James L. Hickey et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Metal-associated amyloid-β species in Alzheimer's disease

(2012) Amit S Pithadia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

(2012) Isabelle Sasaki et al.   DALTON TRANSACTIONS

A Phenylbenzothiazole Conjugate with the Tricarbonyl fac-[M(I)(CO)3]+ (M = Re, 99Tc, 99mTc) Core for Imaging of β-Amyloid Plaques

(2012) Marina Sagnou et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer’s Brains

(2012) Yan Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Cyclopentadienyl Tricarbonyl Complexes of 99mTc Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain

(2012) Zijing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Detection of α-Synuclein Amyloidogenic Aggregates in Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes

(2012) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation

(2012) Michael R. Jones et al.   Metallomics

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Organometallic Complexes for SPECT Imaging and/or Radionuclide Therapy

(2012) Goreti Ribeiro Morais et al.   ORGANOMETALLICS

Inhibitory action of macrocyclic platiniferous chelators on metal-induced Aβ aggregation

(2012) Xiaohui Wang et al.   Chemical Science

The Heterogeneous Nature of Cu2+Interactions with Alzheimer’s Amyloid-β Peptide

(2011) Simon C. Drew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

(2011) Brett M. Paterson et al.   CHEMICAL SOCIETY REVIEWS

Identification of [PtCl2(phen)] Binding Modes in Amyloid-β Peptide and the Mechanism of Aggregation Inhibition

(2011) Guolin Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Curcumin as the OO Bidentate Ligand in “2 + 1” Complexes with the [M(CO)3]+(M = Re,99mTc) Tricarbonyl Core for Radiodiagnostic Applications

(2011) Marina Sagnou et al.   INORGANIC CHEMISTRY

Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes

(2011) Katherine Ann Price et al.   INORGANIC CHEMISTRY

Amyloid-β: The seeds of darkness

(2011) Michelle T. Fodero-Tavoletti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Sensing Amyloid-β Aggregation Using Luminescent Dipyridophenazine Ruthenium(II) Complexes

(2011) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

(2011) Bradley Yat-Wah Man et al.   Chemical Science

Inhibition of Aβ42 Peptide Aggregation by a Binuclear Ruthenium(II)−Platinum(II) Complex: Potential for Multimetal Organometallics as Anti-amyloid Agents

(2010) Amit Kumar et al.   ACS Chemical Neuroscience

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

(2010) SinChun Lim et al.   CHEMICAL COMMUNICATIONS

Identifying the Bond Responsible for the Fluorescence Modulation in an Amyloid Fibril Sensor

(2010) Anvita Srivastava et al.   CHEMISTRY-A EUROPEAN JOURNAL

fac-{Ru(CO)3}2+Selectively Targets the Histidine Residues of the β-Amyloid Peptide 1-28. Implications for New Alzheimer's Disease Treatments Based on Ruthenium Complexes

(2010) Daniela Valensin et al.   INORGANIC CHEMISTRY

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The challenges of determining metal–protein affinities

(2010) Zhiguang Xiao et al.   NATURAL PRODUCT REPORTS

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Fluorescence Quantum Yield of Thioflavin T in Rigid Isotropic Solution and Incorporated into the Amyloid Fibrils

(2010) Anna I. Sulatskaya et al.   PLoS One

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy

(2010) Lauren E. Scott et al.   Chemical Science

Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy

(2009) Tim Storr et al.   DALTON TRANSACTIONS

Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

(2009) Lissette R. Perez et al.   DALTON TRANSACTIONS

18F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A Miniperspective

(2009) Hank F. Kung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Binding of Thioflavin T and Its Neutral Analog BTA-1 to Protofibrils of the Alzheimer’s Disease Aβ16–22 Peptide Probed by Molecular Dynamics Simulations

(2008) Chun Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Platinum-based inhibitors of amyloid-  as therapeutic agents for Alzheimer's disease

(2008) K. J. Barnham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA