Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

Automated Genome Mining of Ribosomal Peptide Natural Products

(2014) Hosein Mohimani et al.   ACS Chemical Biology

Novel LanT Associated Lantibiotic Clusters Identified by Genome Database Mining

(2014) Mangal Singh et al.   PLoS One

A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity

(2013) Marianna Iorio et al.   ACS Chemical Biology

Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry

(2013) Julian D. Hegemann et al.   BIOPOLYMERS

Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis

(2013) Leif Flühe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Prospecting genomes for lasso peptides

(2013) Mikhail O. Maksimov et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor

(2013) Leif Flühe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides

(2013) Auke J. van Heel et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis of the Class III Lantipeptide Catenulipeptin

(2012) Huan Wang et al.   ACS Chemical Biology

Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B0171

(2012) Junji Inokoshi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anaerobic bacteria as producers of antibiotics

(2012) Swantje Behnken et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing

(2012) Ginka H. Völler et al.   CHEMBIOCHEM

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

A genomic approach to the cryptic secondary metabolome of the anaerobic world

(2012) Anne-Catrin Letzel et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A

(2012) Leif Flühe et al.   Nature Chemical Biology

Cryptic Polyketide Synthase Genes in Non-Pathogenic Clostridium SPP

(2012) Swantje Behnken et al.   PLoS One

Precursor-centric genome-mining approach for lasso peptide discovery

(2012) M. O. Maksimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating Antibiotics

(2011) Katie J. Molohon et al.   ACS Chemical Biology

Lichenicidin Biosynthesis in Escherichia coli:licFGEHIImmunity Genes Are Not Essential for Lantibiotic Production or Self-Protection

(2011) Tânia Caetano et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses

(2011) Daniel W. Udwary et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

AS-48 bacteriocin: close to perfection

(2011) Marina Sánchez-Hidalgo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of the amino acid labionin and its desulfurised derivative in the type-III lantibiotic LabA2 by means of GC/MS

(2011) Alexander Pesic et al.   CHEMICAL COMMUNICATIONS

The role of a conserved threonine residue in the leader peptide of lasso peptide precursors

(2011) Si Jia Pan et al.   CHEMICAL COMMUNICATIONS

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Genome Mining for Radical SAM Protein Determinants Reveals Multiple Sactibiotic-Like Gene Clusters

(2011) Kiera Murphy et al.   PLoS One

Structure and genetics of circular bacteriocins

(2011) Marco J. van Belkum et al.   TRENDS IN MICROBIOLOGY

Isolation, Structure Elucidation, and Synergistic Antibacterial Activity of a Novel Two-Component Lantibiotic Lichenicidin fromBacillus licheniformisVK21

(2010) Zakhar O. Shenkarev et al.   BIOCHEMISTRY

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

BACTIBASE second release: a database and tool platform for bacteriocin characterization

(2010) Riadh Hammami et al.   BMC MICROBIOLOGY

Genomics-inspired discovery of natural products

(2010) Jaclyn M Winter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42

(2010) R. Scholz et al.   JOURNAL OF BACTERIOLOGY

Clostridiolysin S, a Post-translationally Modified Biotoxin fromClostridium botulinum

(2010) David J. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

(2010) W.-T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

(2009) M. Begley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into the Biosynthesis and Stability of the Lasso Peptide Capistruin

(2009) Thomas A. Knappe et al.   CHEMISTRY & BIOLOGY

Structure-Function Relationships of the Non-Lanthionine-Containing Peptide (class II) Bacteriocins Produced by Gram-Positive Bacteria

(2009) J. Nissen-Meyer et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides

(2009) Thomas A. Knappe et al.   FEBS LETTERS

Isolation of a Variant of Subtilosin A with Hemolytic Activity

(2009) T. Huang et al.   JOURNAL OF BACTERIOLOGY

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

(2009) Rowan P. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

(2009) John A. McIntosh et al.   NATURAL PRODUCT REPORTS

Recent advances in thiopeptideantibiotic biosynthesis

(2009) Chaoxuan Li et al.   NATURAL PRODUCT REPORTS

Specific Interaction of the Unmodified Bacteriocin Lactococcin 972 with the Cell Wall Precursor Lipid II

(2008) B. Martinez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of a widely distributed toxin biosynthetic gene cluster

(2008) S. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features

(2008) H. Seedorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics

(2008) Yongming Sang et al.   ANIMAL HEALTH RESEARCH REVIEWS