HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses

(2019) Kerong Wang et al.   Cell Reports

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

MAVS maintains mitochondrial homeostasis via autophagy

(2016) Xiaofeng Sun et al.   Cell Discovery

HJV and HFE Play Distinct Roles in Regulating Hepcidin

(2015) Qian Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways?

(2015) Kostas Pantopoulos   HEPATOLOGY

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3

(2015) Kai Guan et al.   JOURNAL OF IMMUNOLOGY

Newly Emergent Highly Pathogenic H5N9 Subtype Avian Influenza A Virus

(2015) Yang Yu et al.   JOURNAL OF VIROLOGY

Hepcidin and Host Defense against Infectious Diseases

(2015) Kathryn Michels et al.   PLoS Pathogens

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

(2014) X.-g. Wu et al.   BLOOD

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Smurf2 Negatively Modulates RIG-I-Dependent Antiviral Response by Targeting VISA/MAVS for Ubiquitination and Degradation

(2014) Y. Pan et al.   JOURNAL OF IMMUNOLOGY

Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs

(2014) Deping Han et al.   VETERINARY MICROBIOLOGY

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

Emergence of a novel drug resistant H7N9 influenza virus: evidence based clinical potential of a natural IFN-α for infection control and treatment

(2013) Qinfang Liu et al.   Expert Review of Anti-Infective Therapy

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

(2009) M. Nairz et al.   BLOOD

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY