Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm

Chronic mTOR activation induces a degradative smooth muscle cell phenotype

(2020) Guangxin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Smooth Muscle Cell Phenotypic Diversity

(2019) Mingjun Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations

(2019) Aditya S. Kalluri et al.   CIRCULATION

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Divergent effects of canonical and non‐canonical TGF‐β signalling on mixed contractile‐synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms

(2019) Albert J. Pedroza et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pathogenesis of aortic wall complications in Marfan syndrome

(2018) Nimrat Grewal et al.   CARDIOVASCULAR PATHOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome

(2018) Gisela Teixido-Tura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Publisher Correction: Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

(2018) Lina Dobnikar et al.   Nature Communications

Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease

(2017) Kirsten Riches et al.   JOURNAL OF VASCULAR RESEARCH

Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome

(2017) Matthew Dale et al.   PLoS One

Vascular smooth muscle cells in Marfan syndrome aneurysm: the broken bricks in the aortic wall

(2016) Gianluca L. Perrucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death

(2016) Alessandra Granata et al.   NATURE GENETICS

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan SyndromeSignificance

(2015) Eva Crosas-Molist et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome

(2015) O. Busnadiego et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

(2014) Sanjay Sinha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

KLF4 Regulates Abdominal Aortic Aneurysm Morphology and Deletion Attenuates Aneurysm Formation

(2013) M. Salmon et al.   CIRCULATION

Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

(2013) M. Groenink et al.   EUROPEAN HEART JOURNAL

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

(2013) Andrew T. Kwon et al.   G3-Genes Genomes Genetics

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome

(2012) Wanfen Xiong et al.   CIRCULATION RESEARCH

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

(2011) Denis R. Merk et al.   CIRCULATION RESEARCH

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle

(2009) Rebecca A. Deaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Therapy of Marfan Syndrome

(2007) Daniel P. Judge et al.   Annual Review of Medicine

Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

(2007) A W Y Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY