Divergent effects of canonical and non‐canonical TGF‐β signalling on mixed contractile‐synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Defective NOTCH signaling drives increased vascular smooth muscle cell apoptosis and contractile differentiation in bicuspid aortic valve aortopathy: A review of the evidence and future directions

(2018) OJ Harrison et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

(2018) Tetsuya Sato et al.   Journal of the American Heart Association

Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease

(2017) Kirsten Riches et al.   JOURNAL OF VASCULAR RESEARCH

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

(2017) Hao Wei et al.   Journal of the American Heart Association

Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome

(2017) Matthew Dale et al.   PLoS One

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death

(2016) Alessandra Granata et al.   NATURE GENETICS

Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan SyndromeSignificance

(2015) Eva Crosas-Molist et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells

(2015) Jeremy T. Baeten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome

(2015) O. Busnadiego et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms

(2015) Adam J. Doyle et al.   JOURNAL OF VASCULAR SURGERY

Temporal and Embryonic Lineage-Dependent Regulation of Human Vascular SMC Development by NOTCH3

(2015) Alessandra Granata et al.   STEM CELLS AND DEVELOPMENT

Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway

(2015) Yang Song et al.   FEBS Open Bio

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

(2014) Sanjay Sinha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

(2013) Gur Yaari et al.   NUCLEIC ACIDS RESEARCH

Vascular Smooth Muscle Cell Smad4 Gene Is Important for Mouse Vascular Development

(2012) Xia Mao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Positive Correlation Between the Dysregulation of Transforming Growth Factor-^|^beta;1 and Aneurysmal Pathological Changes in Patients With Marfan Syndrome

(2012) Koung Li Kim et al.   CIRCULATION JOURNAL

Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease

(2012) Sergio Sciacca et al.   HEART AND VESSELS

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

(2010) Sakiko Inamoto et al.   CARDIOVASCULAR RESEARCH

BAS/BSCR36 Regulation of human smooth muscle cell development by myocardin

(2010) L. Raphel et al.   HEART

Cellular phenotype transformation occurs during thoracic aortic aneurysm development

(2010) Jeffrey A. Jones et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation

(2009) Shirling Tsai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY

Smooth muscle phenotypic modulation is an early event in aortic aneurysms

(2009) Gorav Ailawadi et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Notch and Vascular Smooth Muscle Cell Phenotype

(2008) David Morrow et al.   CIRCULATION RESEARCH