Proton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance

Lactic Acidosis in Sepsis: It’s Not All Anaerobic

(2016) Bandarn Suetrong et al.   CHEST

Acidic environment activates inflammatory programs in fibroblasts via a cAMP–MAPK pathway

(2015) A. Riemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk of Cardiovascular Events in Survivors of Severe Sepsis

(2014) Sachin Yende et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

Anti-TNF-α therapy for patients with sepsis: a systematic meta-analysis

(2014) S. Lv et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

(2014) R. Lavieri et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway

(2013) Michelle E. Edye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Redox control of NLRP3 inflammasome activation in health and disease

(2012) Anna Rubartelli   JOURNAL OF LEUKOCYTE BIOLOGY

Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study

(2012) Mitchell M Levy et al.   LANCET INFECTIOUS DISEASES

After Xigris, researchers look to new targets to combat sepsis

(2012) Sarah C P Williams   NATURE MEDICINE

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Low extracellular pH stimulates the production of IL-1β by human monocytes

(2011) Carolina Cristina Jancic et al.   CYTOKINE

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Safety of Drugs Used in Acid-related Disorders and Functional Gastrointestinal Disorders

(2010) Neehar Parikh et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The Role of Potassium in Inflammasome Activation by Bacteria

(2010) Cecilia S. Lindestam Arlehamn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Metabolic acidosis in patients with severe sepsis and septic shock: A longitudinal quantitative study

(2009) Danilo T. Noritomi et al.   CRITICAL CARE MEDICINE

Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications

(2009) Ramalinga R. Kedika et al.   DIGESTIVE DISEASES AND SCIENCES

Intravenous Proton Pump Inhibitors

(2009) Marc Bardou et al.   DRUGS

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Steroid therapy of septic shock: The decision is in the eye of the beholder

(2008) R Phillip Dellinger   CRITICAL CARE MEDICINE

EXPERIMENTAL MODELS OF SEPSIS AND THEIR CLINICAL RELEVANCE

(2008) Luiz F. Poli-de-Figueiredo et al.   SHOCK