Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

Design Principles for a Compartmentalized Enzyme Cascade Reaction

(2019) Stanislav Tsitkov et al.   ACS Catalysis

Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis

(2019) Laura Rodriguez Arco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precise Regulation of Enzyme Cascade Catalytic Efficiency with DNA Tetrahedron as Scaffold for Ultrasensitive Electrochemical Detection of DNA

(2019) Ding Wang et al.   ANALYTICAL CHEMISTRY

Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks

(2019) Yang Xu et al.   ACS Nano

Two-Dimensional Metal–Organic Framework/Enzyme Hybrid Nanocatalyst as a Benign and Self-Activated Cascade Reagent for in Vivo Wound Healing

(2019) Xinping Liu et al.   ACS Nano

Oriented Assembly of Cell-Mimicking Nanoparticles via a Molecular Affinity Strategy for Targeted Drug Delivery

(2019) Jing Xie et al.   ACS Nano

Shape and Size Control of Artificial Cells for Bottom-Up Biology

(2019) Federico Fanalista et al.   ACS Nano

Rapid Detection of Exosomal MicroRNAs Using Virus-Mimicking Fusogenic Vesicles

(2019) Xihui Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming Rotary Motions with a Hexagonal DNA Nanomachine

(2019) Yangyang Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Artificial Signal Feedback Network Mimicking Cellular Adaptivity

(2019) Hui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multienzymatic Cascade Reactions via Enzyme Complex by Immobilization

(2019) Ee Taek Hwang et al.   ACS Catalysis

Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo

(2019) Jiale Qu et al.   ACS Nano

Self-Assembled Multienzyme Nanostructures on Synthetic Protein Scaffolds

(2019) Zhenjun Liu et al.   ACS Nano

Hierarchical Micro‐ and Mesoporous Zn‐Based Metal–Organic Frameworks Templated by Hydrogels: Their Use for Enzyme Immobilization and Catalysis of Knoevenagel Reaction

(2019) Kaipeng Cheng et al.   Small

Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress

(2019) Gregory A. Ellis et al.   ACS Catalysis

A Diffusion‐Reaction Model for One‐Pot Synthesis of Chemicals with Enzyme Cascades

(2019) You Yong et al.   ChemCatChem

Stimuli-Responsive DNA Microcapsules for SERS Sensing of Trace MicroRNA

(2018) Xia Yang et al.   ACS Applied Materials & Interfaces

Metal–Organic Frameworks for Cell and Virus Biology: A Perspective

(2018) Raffaele Riccò et al.   ACS Nano

Stimuli-Responsive Donor-Acceptor and DNA-Crosslinked Hydrogels: Application as Shape-Memory and Self-Healing Materials

(2018) Chen Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy

(2018) Yannan Yang et al.   ADVANCED FUNCTIONAL MATERIALS

Polymersomes as nanoreactors for preparative biocatalytic applications: current challenges and future perspectives

(2018) Ludwig Klermund et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Integrated nanozymes: facile preparation and biomedical applications

(2018) Jiangjiexing Wu et al.   CHEMICAL COMMUNICATIONS

Engineering enzyme microenvironments for enhanced biocatalysis

(2018) Louis Lancaster et al.   CHEMICAL SOCIETY REVIEWS

Bioinspired construction of multi-enzyme catalytic systems

(2018) Jiafu Shi et al.   CHEMICAL SOCIETY REVIEWS

Wavelength-Selective Light-Responsive DASA-Functionalized Polymersome Nanoreactors

(2018) Omar Rifaie-Graham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami

(2018) Yahong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Responsive SiO2 Nanoparticles, Metal–Organic Frameworks, and Microcapsules for Controlled Drug Release

(2018) Margarita Vázquez-González et al.   LANGMUIR

Engineering thermoresponsive phase separated vesicles formed via emulsion phase transfer as a content-release platform

(2018) Kaiser Karamdad et al.   Chemical Science

Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media

(2018) Mika Henrikki Sipponen et al.   Nature Communications

Sculpting and fusing biomimetic vesicle networks using optical tweezers

(2018) Guido Bolognesi et al.   Nature Communications

Light-triggered enzymatic reactions in nested vesicle reactors

(2018) James W. Hindley et al.   Nature Communications

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

(2018) Lee J. Sweetlove et al.   Nature Communications

Light as Trigger for Biocatalysis: Photonic Wiring of Flavin Adenine Dinucleotide-Dependent Glucose Dehydrogenase to Quantum Dot-Sensitized Inverse Opal TiO2 Architectures via Redox Polymers

(2018) Marc Riedel et al.   ACS Catalysis

Self-Assembling Protein Scaffold System for Easy in Vitro Coimmobilization of Biocatalytic Cascade Enzymes

(2018) Guoqiang Zhang et al.   ACS Catalysis

Engineering Spatially Organized Multi-enzyme Assemblies for Complex Chemical Transformation

(2018) Luke Francesco Bugada et al.   ACS Catalysis

Biomimetic enzyme cascade reaction system in microfluidic electrospray microcapsules

(2018) Huan Wang et al.   Science Advances

Liposomes and polymersomes: a comparative review towards cell mimicking

(2018) Emeline Rideau et al.   CHEMICAL SOCIETY REVIEWS

Shape-memory and self-healing functions of DNA-based carboxymethyl cellulose hydrogels driven by chemical or light triggers

(2018) Chen Wang et al.   Chemical Science

Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories

(2018) Tomoki Nishimura et al.   Advanced Science

Bioinspired Dual-Enzyme Colloidosome Reactors for High-Performance Biphasic Catalysis

(2018) Zhenning Liu et al.   ACS Applied Materials & Interfaces

Metal–Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization

(2018) Munirah Mohammad et al.   ACS Applied Materials & Interfaces

Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging

(2018) Pai Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artificial cell mimics as simplified models for the study of cell biology

(2017) Ali Salehi-Reyhani et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

mRNA-Initiated, Three-Dimensional DNA Amplifier Able to Function inside Living Cells

(2017) Lei He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

(2017) Jicheng Yu et al.   NANO LETTERS

A facile strategy for enzyme immobilization with highly stable hierarchically porous metal–organic frameworks

(2017) Xiao Liu et al.   Nanoscale

Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules

(2017) Aneesh T. Veetil et al.   Nature Nanotechnology

Spatial organization of multi-enzyme biocatalytic cascades

(2017) M. B. Quin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?

(2017) Liubov Poshyvailo et al.   PLoS One

Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

(2017) Wei-Hai Chen et al.   Chemical Science

pH- and ligand-induced release of loads from DNA–acrylamide hydrogel microcapsules

(2017) Wei-Ching Liao et al.   Chemical Science

Toward Rational Design of High-efficiency Enzyme Cascades

(2017) Yifei Zhang et al.   ACS Catalysis

Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes

(2017) Jyun-Liang Lin et al.   ACS Synthetic Biology

Chiroplasmonic DNA-based nanostructures

(2017) Alessandro Cecconello et al.   Nature Reviews Materials

Self-Assembled DNA Hydrogel Based on Enzymatically Polymerized DNA for Protein Encapsulation and Enzyme/DNAzyme Hybrid Cascade Reaction

(2016) Binbin Xiang et al.   ACS Applied Materials & Interfaces

Programmed pH-Responsive Microcapsules for the Controlled Release of CdSe/ZnS Quantum Dots

(2016) Wei-Ching Liao et al.   ACS Nano

The Application of Stimuli-Responsive VEGF- and ATP-Aptamer-Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells

(2016) Wei-Ching Liao et al.   ADVANCED FUNCTIONAL MATERIALS

Stimuli-Responsive DNA-Functionalized Metal-Organic Frameworks (MOFs)

(2016) Jason S. Kahn et al.   ADVANCED MATERIALS

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

(2016) Guoliang Ke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic generation of encapsulated droplet interface bilayer networks (multisomes) and their use as cell-like reactors

(2016) Yuval Elani et al.   CHEMICAL COMMUNICATIONS

Reversible Modulation of DNA-Based Hydrogel Shapes by Internal Stress Interactions

(2016) Yuwei Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spatially Organized Enzymes Drive Cofactor-Coupled Cascade Reactions

(2016) Tien Anh Ngo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Responsive and pH-Responsive DNA Microcapsules for Controlled Release of Loads

(2016) Fujian Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles

(2016) Juan Liu et al.   NANO LETTERS

Substrate channelling as an approach to cascade reactions

(2016) Ian Wheeldon et al.   Nature Chemistry

Enzymatic reactions in confined environments

(2016) Andreas Küchler et al.   Nature Nanotechnology

Programmable polyproteams built using twin peptide superglues

(2016) Gianluca Veggiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling two enzymes into a tandem nanoreactor utilizing a hierarchically structured MOF

(2016) Xizhen Lian et al.   Chemical Science

Lectin Agglutinated Multienzyme Catalyst with Enhanced Substrate Affinity and Activity

(2016) Yifei Zhang et al.   ACS Catalysis

Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substrates

(2016) Edmondo M. Benetti et al.   Journal of Materials Chemistry B

DNA-Based Enzyme Reactors and Systems

(2016) Veikko Linko et al.   Nanomaterials

Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules

(2015) Wei-Ching Liao et al.   ACS Nano

Programmed Synthesis by Stimuli-Responsive DNAzyme-Modified Mesoporous SiO2Nanoparticles

(2015) Dora Balogh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release

(2015) Chun-Hua Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards efficient chemical synthesis via engineering enzyme catalysis in biomimetic nanoreactors

(2015) Jia Liu et al.   CHEMICAL COMMUNICATIONS

Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies

(2015) Yingfeng Tu et al.   CHEMICAL REVIEWS

Optically Resolving the Dynamic Walking of a Plasmonic Walker Couple

(2015) Maximilian J. Urban et al.   NANO LETTERS

Switchable Reconfiguration of Nucleic Acid Nanostructures by Stimuli-Responsive DNA Machines

(2014) Xiaoqing Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

DNA Dendrimer: An Efficient Nanocarrier of Functional Nucleic Acids for Intracellular Molecular Sensing

(2014) Hong-Min Meng et al.   ACS Nano

Gated Mesoporous SiO2Nanoparticles Using K+-Stabilized G-Quadruplexes

(2014) Zhanxia Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Switchable Bifunctional Stimuli-Triggered Poly-N-Isopropylacrylamide/DNA Hydrogels

(2014) Weiwei Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection

(2014) Meihua Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Switches: From Principles to Applications

(2014) Fuan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Cascaded Catalytic Nucleic Acids to Enzyme–DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations, and Assembly of Complex Structures

(2014) Fuan Wang et al.   CHEMICAL REVIEWS

Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures

(2014) Yuwei Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modeling of Enhanced Catalysis in Multienzyme Nanostructures: Effect of Molecular Scaffolds, Spatial Organization, and Concentration

(2014) Christopher C. Roberts et al.   Journal of Chemical Theory and Computation

Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions

(2014) David Gräfe et al.   Nanoscale

Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model

(2014) T-Y. Dora Tang et al.   Nature Chemistry

Reconfigurable 3D plasmonic metamolecules

(2014) Anton Kuzyk et al.   NATURE MATERIALS

Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm

(2014) Jinglin Fu et al.   Nature Nanotechnology

Intracellular Implantation of Enzymes in Hollow Silica Nanospheres for Protein Therapy: Cascade System of Superoxide Dismutase and Catalase

(2014) Feng-Peng Chang et al.   Small

Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways

(2014) Yuval Elani et al.   Nature Communications

Bioinspired Approach to Multienzyme Cascade System Construction for Efficient Carbon Dioxide Reduction

(2014) Xiaoli Wang et al.   ACS Catalysis

Encapsulation of an Enzyme Cascade within the Bacteriophage P22 Virus-Like Particle

(2013) Dustin P. Patterson et al.   ACS Chemical Biology

Origins of Activity Enhancement in Enzyme Cascades on Scaffolds

(2013) Ofer Idan et al.   ACS Nano

Enzyme-Capped Relay-Functionalized Mesoporous Carbon Nanoparticles: Effective Bioelectrocatalytic Matrices for Sensing and Biofuel Cell Applications

(2013) Alexander Trifonov et al.   ACS Nano

Fabrication of Red-Blood-Cell-Like Polyelectrolyte Microcapsules and Their Deformation and Recovery Behavior Through a Microcapillary

(2013) Shupeng She et al.   ADVANCED MATERIALS

Cascade Reactions in Multicompartmentalized Polymersomes

(2013) Ruud J. R. W. Peters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional assembly of a multi-enzyme methanol oxidation cascade on a surface-displayed trifunctional scaffold for enhanced NADH production

(2013) Fang Liu et al.   CHEMICAL COMMUNICATIONS

In vitro reconstitution of a cell-like environment using liposomes for amyloid beta peptide aggregation and its propagation

(2013) Abhijit Saha et al.   CHEMICAL COMMUNICATIONS

Engineering enzymatic cascades on nanoscale scaffolds

(2013) Ofer Idan et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biomolecular scaffolds for enhanced signaling and catalytic efficiency

(2013) Rebecca Chen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Smart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates

(2013) Zhanxia Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aiding Nature’s Organelles: Artificial Peroxisomes Play Their Role

(2013) Pascal Tanner et al.   NANO LETTERS

Third-Party ATP Sensing in Polymersomes: A Label-Free Assay of Enzyme Reactions in Vesicular Compartments

(2013) Umit Hakan Yildiz et al.   Small

Regulation of an Enzyme Cascade Reaction by a DNA Machine

(2013) Ling Xin et al.   Small

Engineering multi-compartment vesicle networks

(2013) Yuval Elani et al.   Chemical Science

Kinetic Enhancements in DNA–Enzyme Nanostructures Mimic the Sabatier Principle

(2013) Jyun-Liang Lin et al.   ACS Catalysis

Design and Analysis of Enhanced Catalysis in Scaffolded Multienzyme Cascade Reactions

(2013) Jyun-Liang Lin et al.   ACS Catalysis

Spatially-Interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures

(2012) Jinglin Fu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Facilitated Substrate Channeling in a Self-Assembled Trifunctional Enzyme Complex

(2012) Chun You et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

(2012) Jinglin Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-Step Rapid Assembly of DNA Origami Nanostructures for Addressable Nanoscale Bioreactors

(2012) Yanming Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Autonomous motors of a metal–organic framework powered by reorganization of self-assembled peptides at interfaces

(2012) Yasuhiro Ikezoe et al.   NATURE MATERIALS

Diffusive transport phenomena in artificial enzyme cascades on scaffolds

(2012) Ofer Idan et al.   Nature Nanotechnology

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen-Bonded Multilayers of Silk Fibroin: From Coatings to Cell-Mimicking Shaped Microcontainers

(2012) Veronika Kozlovskaya et al.   ACS Macro Letters

Engineering DNA-based functional materials

(2011) Young Hoon Roh et al.   CHEMICAL SOCIETY REVIEWS

Polymersomes Spanning from Nano- to Microscales: Advanced Vehicles for Controlled Drug Delivery and Robust Vesicles for Virus and Cell Mimicking

(2011) Fenghua Meng et al.   Journal of Physical Chemistry Letters

Polymersomes in “Gelly” Polymersomes: Toward Structural Cell Mimicry

(2011) Maïté Marguet et al.   LANGMUIR

Organizing DNA Origami Tiles into Larger Structures Using Preformed Scaffold Frames

(2011) Zhao Zhao et al.   NANO LETTERS

A synthetic icosahedral DNA-based host–cargo complex for functional in vivo imaging

(2011) Dhiraj Bhatia et al.   Nature Communications

Enzyme-based logic systems for information processing

(2010) Evgeny Katz et al.   CHEMICAL SOCIETY REVIEWS

Robust and Photocontrollable DNA Capsules Using Azobenzenes

(2010) Fumiaki Tanaka et al.   NANO LETTERS

Emerging applications of stimuli-responsive polymer materials

(2010) Martien A. Cohen Stuart et al.   NATURE MATERIALS

Liposome and Lipid Bilayer Arrays Towards Biosensing Applications

(2010) Marta Bally et al.   Small

Supramolecular Cocaine−Aptamer Complexes Activate Biocatalytic Cascades

(2009) Ronit Freeman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembly of Aptamer−Circular DNA Nanostructures for Controlled Biocatalysis

(2009) Zhen-Gang Wang et al.   NANO LETTERS

Self-Assembly of Enzymes on DNA Scaffolds: En Route to Biocatalytic Cascades and the Synthesis of Metallic Nanowires

(2009) Ofer I. Wilner et al.   NANO LETTERS

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Enzyme cascades activated on topologically programmed DNA scaffolds

(2009) Ofer I. Wilner et al.   Nature Nanotechnology

DNA-directed assembly of artificial multienzyme complexes

(2008) Joachim Müller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Three-Enzyme Cascade Reaction through Positional Assembly of Enzymes in a Polymersome Nanoreactor

(2008) Stijn F. M. van Dongen et al.   CHEMISTRY-A EUROPEAN JOURNAL

A review of stimuli-responsive nanocarriers for drug and gene delivery

(2008) Srinivas Ganta et al.   JOURNAL OF CONTROLLED RELEASE