Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substrates

Unleashing Cancer Cells on Surfaces Exposing Motogenic IGDQ Peptides

(2015) Valentina Corvaglia et al.   Small

pH and redox sensitive albumin hydrogel: A self-derived biomaterial

(2015) S Thirupathi Kumara Raja et al.   Scientific Reports

Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering

(2015) Michel Klein Gunnewiek et al.   Advanced Healthcare Materials

Stem-Cell Clinging by a Thread: AFM Measure of Polymer-Brush Lateral Deformation

(2015) Michel Klein Gunnewiek et al.   Advanced Materials Interfaces

Supramolecular Chemistry at Interfaces: Host–Guest Interactions for Fabricating Multifunctional Biointerfaces

(2014) Hui Yang et al.   ACCOUNTS OF CHEMICAL RESEARCH

25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

(2014) Job Boekhoven et al.   ADVANCED MATERIALS

Complementary Density Gradient of Poly(hydroxyethyl methacrylate) and YIGSR Selectively Guides Migration of Endotheliocytes

(2014) Tanchen Ren et al.   BIOMACROMOLECULES

Cell adhesion mechanisms on laterally mobile polymer films

(2014) Andreas P. Kourouklis et al.   BIOMATERIALS

A Supramolecular Host–Guest Carrier System for Growth Factors Employing VHH Fragments

(2014) Jordi Cabanas-Danés et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine–glycine–aspartate concentration gradient hydrogels

(2013) Laura A. Smith Callahan et al.   Acta Biomaterialia

Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density

(2013) Kyle A. Kyburz et al.   Acta Biomaterialia

Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young’s modulus gradient

(2013) Laura A. Smith Callahan et al.   Acta Biomaterialia

Porous membrane with reverse gradients of PDGF-BB and BMP-2 for tendon-to-bone repair: In vitro evaluation on adipose-derived stem cell differentiation

(2013) Hyun Ki Min et al.   Acta Biomaterialia

Influence of Discrete and Continuous Culture Conditions on Human Mesenchymal Stem Cell Lineage Choice in RGD Concentration Gradient Hydrogels

(2013) Laura A. Smith Callahan et al.   BIOMACROMOLECULES

Guiding cell migration by tugging

(2013) Sergey V Plotnikov et al.   CURRENT OPINION IN CELL BIOLOGY

Patterning of cell-instructive hydrogels by hydrodynamic flow focusing

(2013) Steffen Cosson et al.   LAB ON A CHIP

In vitro evaluation of osteogenesis and myogenesis from adipose-derived stem cells in a pore size gradient scaffold

(2013) Tae Ho Kim et al.   MACROMOLECULAR RESEARCH

Engineering microfluidic concentration gradient generators for biological applications

(2013) Alicia G. G. Toh et al.   Microfluidics and Nanofluidics

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Electrochemical Control of the Enzymatic Polymerization of PEG Hydrogels: Formation of Spatially Controlled Biological Microenvironments

(2013) Vincent Milleret et al.   Advanced Healthcare Materials

Electrospun fibrous scaffolds with continuous gradations in mineral contents and biological cues for manipulating cellular behaviors

(2012) Bin Zou et al.   Acta Biomaterialia

Recent Progress in Interfacial Tissue Engineering Approaches for Osteochondral Defects

(2012) Nathan J. Castro et al.   ANNALS OF BIOMEDICAL ENGINEERING

Surface-Bound Gradients for Studies of Soft Materials Behavior

(2012) Jan Genzer   Annual Review of Materials Research

Creating 3D Angiogenic Growth Factor Gradients in Fibrous Constructs to Guide Fast Angiogenesis

(2012) Xiaolei Guo et al.   BIOMACROMOLECULES

Protein Adsorption Mechanisms Determine the Efficiency of Thermally Controlled Cell Adhesion on Poly(N-isopropyl acrylamide) Brushes

(2012) Sangwook Choi et al.   BIOMACROMOLECULES

Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface

(2012) Satyavrata Samavedi et al.   BIOMATERIALS

PEGylation: An Approach for Drug Delivery. A Review

(2012) Aviral Jain et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Biomolecule Gradient in Micropatterned Nanofibrous Scaffold for Spatiotemporal Release

(2012) Walter Bonani et al.   LANGMUIR

Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach

(2012) Xu Zhang et al.   LANGMUIR

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Gradient biomaterials for soft-to-hard interface tissue engineering

(2011) Azadeh Seidi et al.   Acta Biomaterialia

Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament–bone interface

(2011) Satyavrata Samavedi et al.   Acta Biomaterialia

Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

(2011) Cole A. DeForest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gradients with Depth in Electrospun Fibrous Scaffolds for Directed Cell Behavior

(2011) Harini G. Sundararaghavan et al.   BIOMACROMOLECULES

Three-Dimensional Spatial Patterning of Proteins in Hydrogels

(2011) Ryan G. Wylie et al.   BIOMACROMOLECULES

Creating growth factor gradients in three dimensional porous matrix by centrifugation and surface immobilization

(2011) Se Heang Oh et al.   BIOMATERIALS

The role of plasma proteins in cell adhesion to PEG surface-density-gradient-modified titanium oxide

(2011) Jia Pei et al.   BIOMATERIALS

Gradient nanofibrous chitosan/poly ɛ-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering

(2011) Fengyi Du et al.   BIOMATERIALS

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

(2011) Ana Sala et al.   Integrative Biology

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels

(2011) Ryan G. Wylie et al.   NATURE MATERIALS

Nanofibrous scaffold with incorporated protein gradient for directing neurite outgrowth

(2011) Handarmin et al.   Drug Delivery and Translational Research

Incorporating Protein Gradient into Electrospun Nanofibers As Scaffolds for Tissue Engineering

(2010) Jian Shi et al.   ACS Applied Materials & Interfaces

Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters

(2010) D. Guarnieri et al.   Acta Biomaterialia

Three-dimensional plotted scaffolds with controlled pore size gradients: Effect of scaffold geometry on mechanical performance and cell seeding efficiency

(2010) Jorge M. Sobral et al.   Acta Biomaterialia

Antifouling Coatings: Recent Developments in the Design of Surfaces That Prevent Fouling by Proteins, Bacteria, and Marine Organisms

(2010) Indrani Banerjee et al.   ADVANCED MATERIALS

Investigation of Pore Size Effect on Chondrogenic Differentiation of Adipose Stem Cells Using a Pore Size Gradient Scaffold

(2010) Se Heang Oh et al.   BIOMACROMOLECULES

The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening

(2010) Kaushik Chatterjee et al.   BIOMATERIALS

Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering

(2010) Junmin Zhu   BIOMATERIALS

Programmable microfluidic patterning of protein gradients on hydrogels

(2010) Simone Allazetta et al.   CHEMICAL COMMUNICATIONS

Biological applications of microfluidic gradient devices

(2010) Sudong Kim et al.   Integrative Biology

Biohybrid nanofiber constructs with anisotropic biomechanical properties

(2010) W. Bonani et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Three-dimensional photolithographic patterning of multiple bioactive ligands in poly(ethylene glycol) hydrogels

(2010) Joseph C. Hoffmann et al.   Soft Matter

Patterning hydrogels in three dimensions towards controlling cellular interactions

(2010) Sudhir Khetan et al.   Soft Matter

Capturing Complex Protein Gradients on Biomimetic Hydrogels for Cell-Based Assays

(2009) Steffen Cosson et al.   ADVANCED FUNCTIONAL MATERIALS

Rapid Generation of Biologically Relevant Hydrogels Containing Long-Range Chemical Gradients

(2009) Jiankang He et al.   ADVANCED FUNCTIONAL MATERIALS

Binding Mechanisms in Supramolecular Complexes

(2009) Hans-Jörg Schneider   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Creating gradients of two proteins by differential passive adsorption onto a PEG-density gradient

(2009) Krasimir Vasilev et al.   BIOMATERIALS

PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity

(2009) Stephanie Nemir et al.   BIOTECHNOLOGY AND BIOENGINEERING

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

(2009) Raphael Barbey et al.   CHEMICAL REVIEWS

Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site

(2009) Xiaoran Li et al.   NANO LETTERS

Three-Dimensional Biochemical Patterning of Click-Based Composite Hydrogels via Thiolene Photopolymerization

(2008) Brian D. Polizzotti et al.   BIOMACROMOLECULES

Electrospinning: Applications in drug delivery and tissue engineering

(2008) Travis J. Sill et al.   BIOMATERIALS

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

(2008) Xiaoqin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)

(2008) P. C. Bessa et al.   Journal of Tissue Engineering and Regenerative Medicine

Fabrication of Thermoresponsive Polymer Gradients for Study of Cell Adhesion and Detachment

(2008) Linhui Li et al.   LANGMUIR

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Electrospinning jets and polymer nanofibers

(2008) Darrell H. Reneker et al.   POLYMER

Surface-chemical and -morphological gradients

(2008) Sara Morgenthaler et al.   Soft Matter

Chemoattractive Activity of Sonic Hedgehog in the Adult Subventricular Zone Modulates the Number of Neural Precursors Reaching the Olfactory Bulb

(2008) Elodie Angot et al.   STEM CELLS