No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience

Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

(2020) Benjamin C. Reeves et al.   TRENDS IN MOLECULAR MEDICINE

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

(2019) Sean J. Miller et al.   NATURE NEUROSCIENCE

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

Neuronal Activity Drives Astroglial Connexin 30 in Perisynaptic Processes and Shapes Its Functions

(2019) Grégory Ghézali et al.   CEREBRAL CORTEX

Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains

(2019) Thomas K. Karikari et al.   Frontiers in Cellular Neuroscience

Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex

(2019) Michal Slezak et al.   CURRENT BIOLOGY

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

(2019) Solène Clavreul et al.   Nature Communications

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength

(2018) Kevin W. Kelley et al.   NEURON

An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales

(2018) J. Christopher Octeau et al.   NEURON

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers

(2018) Darin Lanjakornsiripan et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

(2018) Nina Vardjan et al.   Frontiers in Molecular Neuroscience

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

(2018) Cecilia Chavarría et al.   BIOCHEMICAL JOURNAL

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

(2018) Francesco Petrelli et al.   MOLECULAR PSYCHIATRY

Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

(2018) Kevin W. Kelley et al.   NATURE NEUROSCIENCE

Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain

(2018) Lydie Morel et al.   GLIA

Cell Densities in the Mouse Brain: A Systematic Review

(2018) Daniel Keller et al.   Frontiers in Neuroanatomy

Wnt signalling in the development of axon, dendrites and synapses

(2018) Chun-Wei He et al.   Open Biology

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Molecular and Functional Properties of Regional Astrocytes in the Adult Brain

(2017) Lydie Morel et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes locally translate transcripts in their peripheral processes

(2017) Kristina Sakers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Tools to Study Astrocyte Ca2+ Signal Dynamics in Brain Networks In Vivo

(2017) Gabriele Losi et al.   Frontiers in Cellular Neuroscience

Resolving Astrocyte Heterogeneity in the CNS

(2017) W. Todd Farmer et al.   Frontiers in Cellular Neuroscience

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Programmable RNA Tracking in Live Cells with CRISPR/Cas9

(2016) David A. Nelles et al.   CELL

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Dopamine elevates and lowers astroglial Ca2+through distinct pathways depending on local synaptic circuitry

(2016) Alistair Jennings et al.   GLIA

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

(2016) W. T. Farmer et al.   SCIENCE

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Gap junction coupling confers isopotentiality on astrocyte syncytium

(2015) Baofeng Ma et al.   GLIA

Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling

(2015) T.-L. Stephen et al.   JOURNAL OF NEUROSCIENCE

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Direct visualization of newly synthesized target proteins in situ

(2015) Susanne tom Dieck et al.   NATURE METHODS

An astrocyte-dependent mechanism for neuronal rhythmogenesis

(2015) Philippe Morquette et al.   NATURE NEUROSCIENCE

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Disentangling calcium-driven astrocyte physiology

(2015) Dmitri A. Rusakov   NATURE REVIEWS NEUROSCIENCE

Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca2+ in Neurons and Astroglia

(2015) Kaiyu Zheng et al.   NEURON

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein

(2014) W. S. Jackson   Disease Models & Mechanisms

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphismsin Vitroand in Alzheimer Disease Brain

(2014) Asa Hatami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions

(2014) A. Perez-Alvarez et al.   JOURNAL OF NEUROSCIENCE

Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

(2014) J. G. Jackson et al.   JOURNAL OF NEUROSCIENCE

VGluT1+ Neuronal Glutamatergic Signaling Regulates Postnatal Developmental Maturation of Cortical Protoplasmic Astroglia

(2014) L. Morel et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

(2014) Anna V. Molofsky et al.   NATURE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Calcium dynamics in astrocyte processes during neurovascular coupling

(2014) Yo Otsu et al.   NATURE NEUROSCIENCE

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

(2014) Ulrike Pannasch et al.   NATURE NEUROSCIENCE

Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

(2014) Martin D. Haustein et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression

(2013) Vendula Rusnakova et al.   PLoS One

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses

(2013) K. M. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Clonal Identity Determines Astrocyte Cortical Heterogeneity

(2012) Jorge García-Marqués et al.   CEREBRAL CORTEX

Coincident Generation of Pyramidal Neurons and Protoplasmic Astrocytes in Neocortical Columns

(2012) S. Magavi et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Local generation of glia is a major astrocyte source in postnatal cortex

(2012) Woo-Ping Ge et al.   NATURE

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Nanoscopy in a Living Mouse Brain

(2012) S. Berning et al.   SCIENCE

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Fate Mapping and Expression Analysis Reveals Molecular Hallmarks of Prospectively Isolated Adult Neural Stem Cells

(2010) Ruth Beckervordersandforth et al.   Cell Stem Cell

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

The neurobiology of amyotrophic lateral sclerosis

(2010) André Bento-Abreu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins

(2010) Henrietta M. Nielsen et al.   GLIA

Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain

(2010) A. D. R. Garcia et al.   JOURNAL OF NEUROSCIENCE

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes

(2010) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Cytosolic Ca2+ Buffers

(2010) B. Schwaller   Cold Spring Harbor Perspectives in Biology

Heterogeneity in astrocyte morphology and physiology

(2009) Vitali Matyash et al.   BRAIN RESEARCH REVIEWS

Electrical coupling of astrocytes in rat hippocampal slices under physiological and simulated ischemic conditions

(2009) Guangjin Xu et al.   GLIA

Wnt Signals Organize Synaptic Prepattern and Axon Guidance through the Zebrafish unplugged/MuSK Receptor

(2009) Lili Jing et al.   NEURON

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

An FGF-responsive astrocyte precursor isolated from the neonatal forebrain

(2008) Grace Lin et al.   GLIA

Gap Junction-Mediated Astrocytic Networks in the Mouse Barrel Cortex

(2008) V. Houades et al.   JOURNAL OF NEUROSCIENCE

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions

(2008) Dionysia T. Theodosis et al.   PHYSIOLOGICAL REVIEWS

Cortical Layer 1 and Layer 2/3 Astrocytes Exhibit Distinct Calcium Dynamics In Vivo

(2008) Norio Takata et al.   PLoS One

Astrocytes and Ischemic Injury

(2008) T. Takano et al.   STROKE