Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation

The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway

(2019) Yuma Wada et al.   SURGERY TODAY

Dimethyl fumarate, a two-edged drug: Current status and future directions

(2019) Nathaniel Edward Bennett Saidu et al.   MEDICINAL RESEARCH REVIEWS

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

A novel model for in vivo quantification of immediate liver perfusion impairment after pancreatic islet transplantation

(2019) Lucie Kosinova et al.   Islets

Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance

(2019) Johanna Schultheis et al.   Oxidative Medicine and Cellular Longevity

Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets

(2018) Seong Soo Kim et al.   TRANSPLANTATION PROCEEDINGS

Systematic review of islet cryopreservation

(2018) Greg G. Kojayan et al.   Islets

Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells

(2018) Nathaniel Edward Bennett Saidu et al.   Oncotarget

Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway

(2018) Dan-Dan Luo et al.   FOOD AND CHEMICAL TOXICOLOGY

Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications

(2017) Nathaniel Edward Bennett Saidu et al.   MOLECULAR CANCER THERAPEUTICS

Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury

(2017) Chie Takasu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

(2017) Volkan I Sayin et al.   eLife

Is islet transplantation a realistic approach to curing diabetes?

(2017) Sang-Man Jin et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators

(2016) Heide Brandhorst et al.   CELL TRANSPLANTATION

Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2

(2016) Joo-Hyun Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Environmental risk factors for type 1 diabetes

(2016) Marian Rewers et al.   LANCET

Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis

(2016) Lourdes Robles et al.   PANCREAS

The effect of hypoxia on free and encapsulated adult porcine islets-an in vitro study

(2016) Sudhakar Muthyala et al.   XENOTRANSPLANTATION

Effect of dimethyl fumarate on rats with chronic pancreatitis

(2016) Wen-Xian Zhang et al.   Asian Pacific Journal of Tropical Medicine

Respective effects of oxygen and energy substrate deprivation on beta cell viability

(2015) Sandrine Lablanche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pharmacological Activation of Nrf2 Pathway Improves Pancreatic Islet Isolation and Transplantation

(2015) Shiri Li et al.   CELL TRANSPLANTATION

Beta-cell replacement therapy

(2015) Ty B. Dunn et al.   Current Opinion in Organ Transplantation

Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia

(2015) Pratik Choudhary et al.   DIABETES CARE

The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes

(2015) Elango Bhakkiyalakshmi et al.   PHARMACOLOGICAL RESEARCH

Treatment With Dimethyl Fumarate Attenuates Calcineurin Inhibitor-induced Nephrotoxicity

(2015) Chie Takasu et al.   TRANSPLANTATION

The Effect of Nrf2 Pathway Activation on Human Pancreatic Islet Cells

(2015) Yuichi Masuda et al.   PLoS One

Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation

(2014) B. Naziruddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress

(2014) Michael N. Moore   Autophagy

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

(2014) Wenjuan Li et al.   FEBS LETTERS

Dimethyl Fumarate Ameliorates Acute Pancreatitis in Rodent

(2014) Lourdes Robles et al.   PANCREAS

Dimethyl Fumarate Protects Pancreatic Islet Cells and Non-Endocrine Tissue in L-Arginine-Induced Chronic Pancreatitis

(2014) Lourdes Robles et al.   PLoS One

Single-Donor Islet Transplantation and Long-term Insulin Independence in Select Patients With Type 1 Diabetes Mellitus

(2014) David P. Al-Adra et al.   TRANSPLANTATION

Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model

(2013) H. Brandhorst et al.   CELL TRANSPLANTATION

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Beneficial effects of green tea catechin on massive hepatectomy model in rats

(2013) Yu Saito et al.   JOURNAL OF GASTROENTEROLOGY

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   XENOBIOTICA

Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes

(2012) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins

(2011) H. Yamazaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Two Tales of Antioxidant Enzymes on β Cells and Diabetes

(2010) Xin Gen Lei et al.   ANTIOXIDANTS & REDOX SIGNALING

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

(2010) Sara Raimondi et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans

(2010) František Saudek et al.   TRANSPLANTATION

Islets and their antioxidant defense

(2010) Jhankar D. Acharya et al.   Islets

Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf2

(2009) S. Naidu et al.   JOURNAL OF IMMUNOLOGY

Monitoring the survival of islet transplants by MRI using a novel technique for their automated detection and quantification

(2009) Daniel Jirak et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

(2009) Tomonaga Ichikawa et al.   PLoS One

Improvement of Canine Islet Yield by Donor Pancreas Infusion With a p38MAPK Inhibitor

(2009) Taihei Ito et al.   TRANSPLANTATION

Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme

(2008) Ha-Yong Yoon et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation

(2007) Meghana Kanitkar et al.   LIFE SCIENCES