Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression

(2018) Jack Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Nuclear factor kappa B regulated monocyte chemoattractant protein-1/chemokine CC motif receptor-2 expressing in spinal cord contributes to the maintenance of cancer-induced bone pain in rats

(2018) Yungong Wang et al.   Molecular Pain

The Role of Astrocytes in Multiple Sclerosis

(2018) Gerald Ponath et al.   Frontiers in Immunology

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Wensheng Lin et al.   Neural Regeneration Research

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

(2018) Eleanor Sanderson et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

CXCL10 and CXCL13 chemokines in patients with relapsing remitting and primary progressive multiple sclerosis

(2017) Piotr Iwanowski et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci

(2017) Teresa Fazia et al.   Multiple Sclerosis Journal

Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy

(2017) Jessica M. B. Rees et al.   STATISTICS IN MEDICINE

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

(2017) Hirokazu Nakatsumi et al.   Cell Reports

Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci

(2017) Teresa Fazia et al.   Multiple Sclerosis Journal

Cerebellar Dysfunction in Multiple Sclerosis

(2017) Alastair Wilkins   Frontiers in Neurology

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis

(2016) J P Hussman et al.   GENES AND IMMUNITY

Decoding the non-coding genome: elucidating genetic risk outside the coding genome

(2016) C. L. Barr et al.   GENES BRAIN AND BEHAVIOR

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications

(2016) Saskia M. Leibowitz et al.   Frontiers in Molecular Neuroscience

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

(2016) T. F. M. Andlauer et al.   Science Advances

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

(2015) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

(2015) William J. Housley et al.   Science Translational Medicine

A review of instrumental variable estimators for Mendelian randomization

(2015) Stephen Burgess et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

(2015) Fabiola Del Greco M et al.   STATISTICS IN MEDICINE

Expression quantitative trait locus analysis for translational medicine

(2015) Greg Gibson et al.   Genome Medicine

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Tumor Necrosis Factor (TNF)-α Induction of CXCL10 in Endothelial Cells Requires Protein Arginine Methyltransferase 5 (PRMT5)-mediated Nuclear Factor (NF)-κB p65 Methylation

(2014) Daniel P. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

The Biological Functions, Structure and Sources of CXCL10 and Its Outstanding Part in the Pathophysiology of Multiple Sclerosis

(2014) Reza Vazirinejad et al.   NEUROIMMUNOMODULATION

p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes

(2014) U. Lo et al.   Scientific Reports

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

TNFRSF1A in multiple sclerosis: A tale of soluble receptors and signaling cascades

(2013) P. J. Tienari et al.   NEUROLOGY

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

(2013) Conor Mc Guire et al.   TRENDS IN MOLECULAR MEDICINE

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

(2013) Nikolaos A. Patsopoulos et al.   PLoS Genetics

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

(2011) Daniah Trabzuni et al.   JOURNAL OF NEUROCHEMISTRY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis

(2009) J. Yan et al.   CNS & Neurological Disorders-Drug Targets

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS