The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

(2020) Joshua D. Webster et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases

(2020) Simone Jensen et al.   Science Signaling

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

(2020) Sofie Martens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

(2020) Lien Verboom et al.   Cell Reports

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

(2020) Rune Busk Damgaard et al.   CELL DEATH AND DIFFERENTIATION

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

(2020) Arne Martens et al.   NATURE IMMUNOLOGY

Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis–like disease and inflammation

(2020) Bahram Razani et al.   NATURE IMMUNOLOGY

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

(2020) Lucie Laurien et al.   Nature Communications

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development

(2019) Xuhua Zhang et al.   Cell Death & Disease

Auto-inflammation in a Patient with a Novel Homozygous OTULIN Mutation

(2019) Mohammad Nabavi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

(2019) Rune Busk Damgaard et al.   EMBO Molecular Medicine

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

(2019) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation

(2019) Jieqiong Zhang et al.   Cell Reports

Primary immunodeficiency with chronic enteropathy and developmental delay in a boy arising from a novel homozygous RIPK1 variant

(2019) Yuri Uchiyama et al.   JOURNAL OF HUMAN GENETICS

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification

(2019) Mona Abed et al.   PLoS One

DNL 104, a Centrally Penetrant RIPK 1 Inhibitor, Inhibits RIP 1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

(2019) Hendrika W. Grievink et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

Intracellular regulation of TNF activity in health and disease

(2018) Eugene Varfolomeev et al.   CYTOKINE

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

Anti-TNF Therapy in Crohn’s Disease

(2018) Samuel O. Adegbola et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

(2018) Lucia Taraborrelli et al.   Nature Communications

Corrigendum: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2018) Ran Wei et al.   GENES & DEVELOPMENT

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genomics, Biology, and Human Illness

(2017) Hirotsugu Oda et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

(2016) Madalina-Viviana Nastase et al.   AMERICAN JOURNAL OF PATHOLOGY

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

(2016) Rune Busk Damgaard et al.   CELL

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice

(2015) Syu-Jhe Chien et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

(2015) Bertrand Boisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

Spontaneous retrotransposon insertion intoTNF3′UTR causes heart valve disease and chronic polyarthritis

(2015) Derek Lacey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

(2014) Christopher S. Potter et al.   PLoS One

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

A Plug Release Mechanism for Membrane Permeation by MLKL

(2014) Lijing Su et al.   STRUCTURE

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

(2014) J. Majkut et al.   Nature Communications

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

(2014) Nieves Peltzer et al.   Cell Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

(2014) Snehlata Kumari et al.   eLife

Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1

(2013) Johanna Nilsson et al.   ANNALS OF NEUROLOGY

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Circulating levels of TNF-like cytokine 1A correlate with the progression of atheromatous lesions in patients with rheumatoid arthritis

(2013) G. Bamias et al.   CLINICAL IMMUNOLOGY

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

(2013) Wanze Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling

(2013) Tamas Sessler et al.   PHARMACOLOGY & THERAPEUTICS

Intestinal-Specific TNFα Overexpression Induces Crohn’s-Like Ileitis in Mice

(2013) Giorgos Bamias et al.   PLoS One

Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement

(2013) Kai Wang et al.   Genome Medicine

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

(2012) Fuminori Tokunaga et al.   EMBO JOURNAL

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

(2012) Fuminori Tokunaga et al.   MICROBES AND INFECTION

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Inhibition of NF-κB Signaling Retards Eosinophilic Dermatitis in SHARPIN-Deficient Mice

(2010) Yanhua Liang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

(2008)   ARTHRITIS AND RHEUMATISM

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB Suppression by the Deubiquitinating Enzyme Cezanne

(2008) Karine Enesa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA