Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-05-05
DOI
10.3389/fcell.2020.00258
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Improving mesenchymal stem/stromal cell potency and survival
- (2020) Jan A. Nolta et al. CYTOTHERAPY
- Mesenchymal Stem Cells Beyond Regenerative Medicine
- (2020) Riam Shammaa et al. Frontiers in Cell and Developmental Biology
- Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells
- (2019) Alessandro Bertolo et al. Scientific Reports
- Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
- (2019) Rhys Anderson et al. EMBO JOURNAL
- An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program
- (2019) Daniela Gnani et al. AGING CELL
- Rapid Detection of Senescent Mesenchymal Stromal Cells by a Fluorescent Probe
- (2019) Joshur Ang et al. Biotechnology Journal
- From discoveries in ageing research to therapeutics for healthy ageing
- (2019) Judith Campisi et al. NATURE
- CD146/MCAM distinguishes stem cell subpopulations with distinct migration and regenerative potential in degenerative intervertebral discs
- (2019) S. Wangler et al. OSTEOARTHRITIS AND CARTILAGE
- Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence
- (2019) Prakhar Mishra et al. Scientific Reports
- Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury
- (2019) Ruoqiong Huang et al. Aging-US
- Mesenchymal stem versus stromal cells: International Society for Cellular Therapy Mesenchymal Stromal Cell committee position statement on nomenclature
- (2019) S. Viswanathan et al. CYTOTHERAPY
- Survival of aging CD264 + and CD264 − populations of human bone marrow mesenchymal stem cells is independent of colony‐forming efficiency
- (2019) Sean D. Madsen et al. BIOTECHNOLOGY AND BIOENGINEERING
- Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair
- (2019) Yuelin Zhang et al. Aging-US
- Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities
- (2018) Jacques Galipeau et al. Cell Stem Cell
- Spontaneous up-regulation of SIRT1 during osteogenesis contributes to stem cells’ resistance to oxidative stress
- (2018) Mao Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
- (2018) S. Oja et al. Stem Cell Research & Therapy
- Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity
- (2018) Miriam Bracha Ginzberg et al. eLife
- Allogeneic Mesenchymal Stem Cell Transplantation in Severe and Refractory Systemic Lupus Erythematosus: 4 Years of Experience
- (2018) Dandan Wang et al. CELL TRANSPLANTATION
- Inflammaging: a new immune–metabolic viewpoint for age-related diseases
- (2018) Claudio Franceschi et al. Nature Reviews Endocrinology
- Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids
- (2018) Bruno Corrêa Bellagamba et al. Stem Cells International
- Overexpression of ERBB4 rejuvenates aged mesenchymal stem cell and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathway
- (2018) Xiaoting Liang et al. FASEB JOURNAL
- Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases
- (2018) Yu Fujita et al. Journal of Clinical Medicine
- An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle
- (2017) Jan Niemann et al. FREE RADICAL BIOLOGY AND MEDICINE
- Senescence of mesenchymal stem cells (Review)
- (2017) Yi Li et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation
- (2017) Ryan A. Denu Oxidative Medicine and Cellular Longevity
- Mitochondrial Sirtuins and Molecular Mechanisms of Aging
- (2017) Robert A.H. van de Ven et al. TRENDS IN MOLECULAR MEDICINE
- Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells
- (2017) Sean D. Madsen et al. Stem Cell Research & Therapy
- Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies
- (2017) Travis J. Block et al. Stem Cell Research & Therapy
- Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells
- (2017) Qian Lei et al. Theranostics
- Aging, Obesity, and Inflammatory Age-Related Diseases
- (2017) Daniela Frasca et al. Frontiers in Immunology
- Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule
- (2016) Takeshi Yamamoto et al. Autophagy
- Clinical Trials with Mesenchymal Stem Cells: An Update
- (2016) Tiziana Squillaro et al. CELL TRANSPLANTATION
- hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine
- (2016) Vikram Sabapathy et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The Impact of Epigenetics on Mesenchymal Stem Cell Biology
- (2016) Yusuf Ozkul et al. JOURNAL OF CELLULAR PHYSIOLOGY
- mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging
- (2016) Koji Takayama et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Clinical-scale expansion of mesenchymal stromal cells: a large banking experience
- (2016) Chantal Lechanteur et al. Journal of Translational Medicine
- Immunologic properties of differentiated and undifferentiated mesenchymal stem cells derived from umbilical cord blood
- (2016) Hyo-Jong Lee et al. Journal of Veterinary Science
- Autophagy maintains stemness by preventing senescence
- (2016) Laura García-Prat et al. NATURE
- High Content Imaging of Early Morphological Signatures Predicts Long Term Mineralization Capacity of Human Mesenchymal Stem Cells upon Osteogenic Induction
- (2016) Ross A. Marklein et al. STEM CELLS
- Bistable Epigenetic States Explain Age-Dependent Decline in Mesenchymal Stem Cell Heterogeneity
- (2016) Zahia Hamidouche et al. STEM CELLS
- Cross-Talking Between PPAR and WNT Signaling and its Regulation in Mesenchymal Stem Cell Differentiation
- (2016) Chenyuan Xu et al. Current Stem Cell Research & Therapy
- Downregulation of Melanoma Cell Adhesion Molecule (MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
- (2016) Hye Jin Jin et al. Stem Cells Translational Medicine
- Characterization of bone marrow-derived mesenchymal stem cells in aging
- (2015) Natasha Baker et al. BONE
- De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins
- (2015) Tiziana Squillaro et al. CELL CYCLE
- Senescence from G2 arrest, revisited
- (2015) Véronique Gire et al. CELL CYCLE
- Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation
- (2015) Sébastien Sart et al. Oxidative Medicine and Cellular Longevity
- Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases
- (2015) Se-Ran Yang et al. Oxidative Medicine and Cellular Longevity
- Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells
- (2015) Wenzheng Xia et al. Stem Cell Research & Therapy
- Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response
- (2014) Martha L. Bustos et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size
- (2014) Teemu P. Miettinen et al. CURRENT BIOLOGY
- Telomere Length
- (2014) Alison J. Montpetit et al. NURSING RESEARCH
- Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model
- (2014) Juan Carlos Sepúlveda et al. STEM CELLS
- Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells
- (2014) Joana Frobel et al. Stem Cell Reports
- Immunogenicity of undifferentiated and differentiated allogeneic mouse mesenchymal stem cells
- (2014) Blessing Mukonoweshuro et al. Journal of Tissue Engineering
- α-Fucosidase as a novel convenient biomarker for cellular senescence
- (2013) Dominic Hildebrand et al. CELL CYCLE
- Senescence-associated lysosomalα-L-fucosidase (SA-α-Fuc): A sensitive and more robust biomarker for cellular senescence beyond SA-β-Gal
- (2013) Madhurendra Singh et al. CELL CYCLE
- Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging
- (2013) Chih-Hao Wang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Mesenchymal Stem Cells from iPS Cells Facilitate Periodontal Regeneration
- (2013) K. Hynes et al. JOURNAL OF DENTAL RESEARCH
- Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation
- (2013) Aideen E Ryan et al. MOLECULAR THERAPY
- Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy
- (2012) Donald G. Phinney JOURNAL OF CELLULAR BIOCHEMISTRY
- Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells
- (2012) Masahiko Kanehira et al. PLoS One
- Functional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells
- (2012) Sven Geißler et al. PLoS One
- Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential
- (2012) May Al-Nbaheen et al. Stem Cell Reviews and Reports
- Effects of Medium Supplements on Proliferation, Differentiation Potential, and In Vitro Expansion of Mesenchymal Stem Cells
- (2012) Borzo Gharibi et al. Stem Cells Translational Medicine
- Autophagy: for better or for worse
- (2011) Ellen Wirawan et al. CELL RESEARCH
- Population dynamics of mesenchymal stromal cells during culture expansion
- (2011) Anne Schellenberg et al. CYTOTHERAPY
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- (2011) Hong-Feng Yuan et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning
- (2011) Anastasia Efimenko et al. Journal of Translational Medicine
- Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow
- (2010) Ji Min Yu et al. AGING CELL
- Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice
- (2010) Qizhou Lian et al. CIRCULATION
- The DNA Damage Response: Making It Safe to Play with Knives
- (2010) Alberto Ciccia et al. MOLECULAR CELL
- Linking functional decline of telomeres, mitochondria and stem cells during ageing
- (2010) Ergün Sahin et al. NATURE
- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- The Effect of Age on the Efficacy of Human Mesenchymal Stem Cell Transplantation after a Myocardial Infarction
- (2010) Ming Fan et al. REJUVENATION RESEARCH
- A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone
- (2010) Claudia Bruedigam et al. STEM CELLS
- Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice
- (2009) Mohsin Khan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity
- (2009) Y. Zhang et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Insights into Mesenchymal Stem Cell Aging: Involvement of Antioxidant Defense and Actin Cytoskeleton
- (2009) Grit Kasper et al. STEM CELLS
- Mitochondrial generation of free radicals and hypoxic signaling
- (2009) Robert O. Poyton et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells
- (2008) James D Kretlow et al. BMC CELL BIOLOGY
- Aging and Disease as Modifiers of Efficacy of Cell Therapy
- (2008) Stefanie Dimmeler et al. CIRCULATION RESEARCH
- Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders
- (2008) Ying Jiang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration
- (2008) Christophe Le Clainche et al. PHYSIOLOGICAL REVIEWS
- Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
- (2008) Wolfgang Wagner et al. PLoS One
- Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
- (2007) A. Stolzing et al. MECHANISMS OF AGEING AND DEVELOPMENT
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now