Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

Good responses but high TRM in adult patients after MSC therapy for GvHD

(2016) U Salmenniemi et al.   BONE MARROW TRANSPLANTATION

International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials

(2016) Jacques Galipeau et al.   CYTOTHERAPY

High Content Imaging of Early Morphological Signatures Predicts Long Term Mineralization Capacity of Human Mesenchymal Stem Cells upon Osteogenic Induction

(2016) Ross A. Marklein et al.   STEM CELLS

A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells

(2015) Anita Laitinen et al.   CYTOTECHNOLOGY

Standardization of Good Manufacturing Practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications

(2015) Patrick Wuchter et al.   CYTOTHERAPY

Establishing Criteria for Human Mesenchymal Stem Cell Potency

(2015) Rebekah M. Samsonraj et al.   STEM CELLS

Label-Free Morphology-Based Prediction of Multiple Differentiation Potentials of Human Mesenchymal Stem Cells for Early Evaluation of Intact Cells

(2014) Hiroto Sasaki et al.   PLoS One

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells

(2013) Jessica L. Lo Surdo et al.   CYTOTHERAPY

Risk of tumorigenicity in mesenchymal stromal cell–based therapies—Bridging scientific observations and regulatory viewpoints

(2013) Lisbeth Barkholt et al.   CYTOTHERAPY

Morphology-Based Prediction of Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells

(2013) Fumiko Matsuoka et al.   PLoS One

Onset of heterogeneity in culture-expanded bone marrow stromal cells

(2013) Matthew J. Whitfield et al.   Stem Cell Research

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

(2013) Ratti Ram Sharma et al.   TRANSFUSION

Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review

(2013) Luc Sensebé et al.   Stem Cell Research & Therapy

Recent Advances in Morphological Cell Image Analysis

(2012) Shengyong Chen et al.   Computational and Mathematical Methods in Medicine

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

(2012) Lotta Kilpinen et al.   JOURNAL OF LIPID RESEARCH

The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells

(2010) Laila Bendix et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

(2010) Masayuki Kimura et al.   Nature Protocols

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

(2009) Simone Bork et al.   AGING CELL

Senescent Keratinocytes Die by Autophagic Programmed Cell Death

(2009) Karo Gosselin et al.   AMERICAN JOURNAL OF PATHOLOGY

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

(2009) K. Tarte et al.   BLOOD

Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells

(2008) Yoshihiro Katsube et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One