CRISPR/Cas9-Mediated Biallelic Knockout of IRX3 Reduces the Production and Survival of Somatic Cell-Cloned Bama Minipigs

Intrinsic and extrinsic molecular determinants or modulators for epigenetic remodeling and reprogramming of somatic cell-derived genome in mammalian nuclear-transferred oocytes and resultant embryos

(2023) M. Samiec et al.   POLISH JOURNAL OF VETERINARY SCIENCES

Genome editing in large animals: Current status and future prospects

(2019) Jianguo Zhao et al.   National Science Review

Expression of pluripotency‐related genes is highly dependent on trichostatin A‐assisted epigenomic modulation of porcine mesenchymal stem cells analysed for apoptosis and subsequently used for generating cloned embryos

(2019) Marcin Samiec et al.   ANIMAL SCIENCE JOURNAL

Comparative study of the developmental competence of cloned pig embryos derived from spermatogonial stem cells and fetal fibroblasts

(2019) Joohyeong Lee et al.   REPRODUCTION IN DOMESTIC ANIMALS

Effects of resveratrol on in vitro maturation of porcine oocytes and subsequent early embryonic development following somatic cell nuclear transfer

(2019) Xuefang Wang et al.   REPRODUCTION IN DOMESTIC ANIMALS

5-Azacytidine improves the meiotic maturation and subsequent in vitro development of pig oocytes

(2019) Mukesh Kumar Gupta et al.   ANIMAL REPRODUCTION SCIENCE

Efficient generation of GHR knockout Bama minipig fibroblast cells using CRISPR/Cas9-mediated gene editing

(2019) Rui Wang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

(2018) Sen Yan et al.   CELL

Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing

(2018) Xuan Yao et al.   CELL RESEARCH

The Histone Deacetylase Inhibitor, CI994, Improves Nuclear Reprogramming and In Vitro Developmental Potential of Cloned Pig Embryos

(2018) Long Jin et al.   Cellular Reprogramming

MC1568 Enhances Histone Acetylation During Oocyte Meiosis and Improves Development of Somatic Cell Nuclear Transfer Embryos in Pig

(2018) Huili Wang et al.   Cellular Reprogramming

A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9

(2018) Tingting Sui et al.   Disease Models & Mechanisms

Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer

(2018) Chong Feng et al.   Journal of Genetics and Genomics

Tauroursodeoxycholic acid (TUDCA) alleviates endoplasmic reticulum stress of nuclear donor cells under serum starvation

(2018) Ying Zhang et al.   PLoS One

The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals

(2018) Shady Younis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of gene-editing technology to introduce targeted modifications in pigs

(2018) Junghyun Ryu et al.   Journal of Animal Science and Biotechnology

Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs

(2018) Guanghai Xiang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generation of transgenic-cloned Huanjiang Xiang pigs systemically expressing enhanced green fluorescent protein

(2018) Xiang-Xing Zhu et al.   REPRODUCTION IN DOMESTIC ANIMALS

CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson’s Disease

(2018) Xiang-Xing Zhu et al.   Scientific Reports

Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

(2018) Bin Fang et al.   Disease Models & Mechanisms

Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1

(2018) Geon A Kim et al.   TRANSGENIC RESEARCH

Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs

(2018) Xiaofeng Liu et al.   TRANSGENIC RESEARCH

Genetically modified pigs are protected from classical swine fever virus

(2018) Zicong Xie et al.   PLoS Pathogens

A genetically inducible porcine model of intestinal cancer

(2017) Morten M. Callesen et al.   Molecular Oncology

Quisinostat treatment improves histone acetylation and developmental competence of porcine somatic cell nuclear transfer embryos

(2017) Long Jin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Reconstitution ofUCP1using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

(2017) Qiantao Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basics of genome editing technology and its application in livestock species

(2017) Bjoern Petersen   REPRODUCTION IN DOMESTIC ANIMALS

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells

(2017) J. Opiela et al.   THERIOGENOLOGY

Genome editing in livestock: Are we ready for a revolution in animal breeding industry?

(2017) Jinxue Ruan et al.   TRANSGENIC RESEARCH

Dnmt1s in donor cells is a barrier to SCNT-mediated DNA methylation reprogramming in pigs

(2017) Xuexiong Song et al.   Oncotarget

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

(2017) Christine Burkard et al.   PLoS Pathogens

Tauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition

(2016) Tao Lin et al.   Reproductive Biology

Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP

(2016) Yanzhen Bi et al.   Scientific Reports

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9

(2016) Qingyan Lv et al.   Scientific Reports

Successful cloning of an adult breeding boar from the novel Chinese Guike No. 1 swine specialized strain

(2016) Jun-yu Nie et al.   3 Biotech

Successful cloning of an adult breeding boar from the novel Chinese Guike No. 1 swine specialized strain

(2016) Jun-yu Nie et al.   3 Biotech

In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig

(2015) Xiangxing Zhu et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation of gene-target dogs using CRISPR/Cas9 system

(2015) Qingjian Zou et al.   Journal of Molecular Cell Biology

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System

(2015) Kankan Wang et al.   Scientific Reports

Trichostatin A-Mediated Epigenetic Transformation of Adult Bone Marrow-Derived Mesenchymal Stem Cells Biases theIn VitroDevelopmental Capability, Quality, and Pluripotency Extent of Porcine Cloned Embryos

(2015) Marcin Samiec et al.   Biomed Research International

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Biological transcomplementary activation as a novel and effective strategy applied to the generation of porcine somatic cell cloned embryos

(2014) Marcin Samiec et al.   Reproductive Biology

Creation of cloned pig embryos using contact-inhibited or serum-starved fibroblast cells analysed intravitam for apoptosis occurrence / Uzyskiwanie klonalnych zarodków świni z wykorzystaniem komórek fibroblastycznych poddanych inhibicji kontaktowej lub deprywacji troficznej oraz analizowanych przyżyciowo w kierunku apoptozy

(2013) Marcin Samiec et al.   Annals of Animal Science

Assessment of in vitro developmental capacity of porcine nuclear-transferred embryos reconstituted with cumulus oophorus cells undergoing vital diagnostics for apoptosis detection / Ocena zdolności rozwojowych in vitro klonalnych zarodków świni rekonstytuowanych z jąder komórek wzgórka jajonośnego poddawanych przyżyciowej diagnostyce w kierunku wykrywania apoptozy

(2013) Marcin Samiec et al.   Annals of Animal Science

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Bone Marrow Mesenchymal Stem Cells Are an Attractive Donor Cell Type for Production of Cloned Pigs As Well As Genetically Modified Cloned Pigs by Somatic Cell Nuclear Transfer

(2013) Zicong Li et al.   Cellular Reprogramming

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems

(2013) Wei Li et al.   NATURE BIOTECHNOLOGY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

The effects of artificial activation timing on the development of SCNT-derived embryos and newborn piglets

(2013) Jae-Il Bang et al.   Reproductive Biology

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2013) Andrew R. Bassett et al.   Cell Reports

Iroquois Homeodomain Transcription Factors in Heart Development and Function

(2012) Kyoung-Han Kim et al.   CIRCULATION RESEARCH

Roscovitine is a novel agent that can be used for the activation of porcine oocytes reconstructed with adult cutaneous or fetal fibroblast cell nuclei

(2012) M. Samiec et al.   THERIOGENOLOGY

The possibilities of practical application of transgenic mammalian species generated by somatic cell cloning in pharmacology, veterinary medicine and xenotransplantology

(2011) M. Samiec et al.   POLISH JOURNAL OF VETERINARY SCIENCES

Transgenic mammalian species, generated by somatic cell cloning, in biomedicine, biopharmaceutical industry and human nutrition/dietetics - recent achievements

(2011) M. Samiec et al.   POLISH JOURNAL OF VETERINARY SCIENCES

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network

(2011) S.-S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA