Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Huawei Xu, Zhibin Hao, Yujie Wang, Deng Zhang, Jie Li, Ling Chen, Ninghua Yao, Binbin Qian, Xiaobo Peng, Xianbao Zhan
Summary: Gastric cancer, a prevalent tumor globally, is often fatal due to peritoneal metastasis. However, the underlying mechanism of peritoneal metastasis remains unclear. Our study using organoids derived from malignant ascites of gastric cancer patients revealed that the interaction between exfoliated cancer cells and the liquid tumor microenvironment plays a crucial role in peritoneal metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Jhalak Dholakia, Carly B. Scalise, Ashwini A. Katre, Whitney N. Goldsberry, Selene Meza-Perez, Troy D. Randall, Lyse A. Norian, Lea Novak, Rebecca C. Arend
Summary: The study showed that Wnt/beta-catenin pathway modulation increases MHC I expression and promotes tumor leukocytic infiltration, facilitating a pro-immune TME associated with decreased tumor burden. This intervention overcomes common tumor immune-evasion mechanisms and may render ovarian tumors susceptible to immunotherapy.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Gui-Xian Zhu, Dian Gao, Zhao-Zhao Shao, Li Chen, Wen-Jie Ding, Qiong-Fang Yu
Summary: The unsatisfactory effect of chemotherapy in colorectal cancer is mainly due to the presence of highly metastatic tumor stem cells, regulation of non-coding RNAs, and the tumor microenvironment. The Wnt/beta-catenin signaling pathway plays a crucial role in mediating chemoresistance in CRC by impacting these factors.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
J. A. Wall, S. Meza-Perez, C. B. Scalise, A. Katre, A. Londono, W. J. Turbitt, T. Randall, L. A. Norian, R. C. Arend
Summary: This study evaluated the anti-tumor and immune-enhancing properties of the Wnt inhibitor CGX-1321 in ovarian cancer. Results showed that CGX-1321 significantly reduced tumor burden and increased CD8+ T cell infiltration. Although the addition of DKN-01 or anti-PD-1 therapies did not enhance the effects of CGX-1321, further investigation is needed to determine if CGX-1321 + DKN-01 combination treatment sensitizes pre-clinical ovarian cancer to ICB therapy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Article
Oncology
Fang Feng, Chunliang Liu, Huahui Bian, Wei Cai, Ying Zhou, Li Zhou, Zhixiang Zhuang
Summary: Pancreatic cancer is a major cause of cancer-related deaths, and understanding the role of TIPE2 in pancreatic cancer is crucial. This study found that decreased expression of TIPE2 in pancreatic cancer tissues was associated with tumor size, and overexpression of TIPE2 inhibited cell proliferation and metastasis while promoting apoptotic events. TIPE2 may suppress pancreatic cancer development by inhibiting PI3K/AKT and Raf/MEK/ERK signaling pathways and activating T cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Hiroki Tage, Kiyoshi Yamaguchi, Saya Nakagawa, So Kasuga, Kiyoko Takane, Yoichi Furukawa, Tsuneo Ikenoue
Summary: In this study, novel target genes of the Wnt/β-catenin signaling pathway were identified in cancer cells. One of these genes, Visinin-like 1 (VSNL1), was found to be regulated by the β-catenin/TCF7L2 complex via TCF7L2-binding elements and involved in apoptosis resistance in colorectal cancer cells.
Article
Cell Biology
Jingling Zhao, Shuai Yang, Yingbin Xu, Shitian Qin, Fan Bie, Lei Chen, Fei Zhou, Julin Xie, Xusheng Liu, Bin Shu, Shaohai Qi
Summary: Pressure therapy (PT) is an effective intervention for reducing scarring, and our study reveals that PT induces the dedifferentiation of scar-derived myofibroblasts into fibroblasts through the downregulation of SMYD3/ITGBL1. Clinical observations show that the reductions in SMYD3 and ITGBL1 are associated with the anti-scarring effects of PT. Mechanistically, PT inhibits the integrin beta 1/ILK pathway, leading to the downregulation of TCF-4 and subsequently suppressing the expression of SMYD3 and ITGBL1, resulting in the dedifferentiation of myofibroblasts into fibroblasts.
DEVELOPMENTAL CELL
(2023)
Review
Biochemistry & Molecular Biology
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, Jane Siu-Fan Li, Alex Siu-Wing Chan, Philip Chiu-Tsun Tang, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: TGF-beta signaling plays crucial roles in inflammatory diseases by regulating immunocytes in tissue fibrosis and accelerating tumor development in cancer. The pleiotropic nature of TGF-beta signaling in generating fibrotic TME, containing CAFs and matrix proteins, remains largely unclear, despite recent studies demonstrating its clinical implications in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.