Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Article
Environmental Sciences
Yuzhuo Chen, Zhirong Yang, Xingqiang He, Wanglong Zhu, Yujun Wang, Jiaofeng Li, Zhengyu Han, Jie Wen, Wei Liu, Yuhan Yang, Kun Zhang
Summary: Proanthocyanidins (PC) have powerful antioxidant and anti-aging effects, and play an important role in tumor cell growth, drug resistance, recurrence, and metastasis. Recent studies have found that PC exhibits inhibitory effects on colorectal cancer stem cells (CSCs) through the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Qilin Li, Ding Xia, Zhihua Wang, Bo Liu, Jing Zhang, Ping Peng, Qiujun Tang, Jie Dong, Juan Guo, Dong Kuang, Weimin Chen, Jing Mao, Qiuhui Li, Xin Chen
Summary: The study identified that circadian rhythm gene PER3 acts as a negative regulator in prostate cancer stem cells (PCSCs), controlling their stemness through the WNT/beta-catenin signaling pathway in the tumor microenvironment. PER3 downregulation is associated with enhanced tumor-initiating abilities, while PER3 overexpression suppresses tumorigenicity and colony-forming capacities in PCa cells, suggesting a potential novel therapeutic strategy for PCa patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Shweta Arora, Salman Khan, Almaz Zaki, Gulnaz Tabassum, Mohd Mohsin, Humaira Naaz Bhutto, Tanveer Ahmad, Tasneem Fatma, Mansoor Ali Syed
Summary: This article discusses the role of chemokines and non-coding RNAs in modulating tumor progression, as well as their communication in the tumor microenvironment and potential as novel therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Zhaoxu Wu, Qiang Ju
Summary: This review discusses the role and mechanism of non-coding RNAs in the colorectal cancer microenvironment, as well as possible clinical treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yanmei Zhang, Zixuan Wang, Qifan Hu, Hao Luo, Bingchuan Lu, Yunhe Gao, Zhi Qiao, Yongsen Zhou, Yongcong Fang, Jin Gu, Ting Zhang, Zhuo Xiong
Summary: This study identifies a new biomaterial and method for inducing and enriching colorectal cancer stem cells (CSCs) using three-dimensional bioprinting. The use of GelMA-nanoclay hydrogels promotes the formation of spheroids expressing stemness markers and enhances the self-renewal, differentiation, and tumorigenic capacity of cancer cells in vitro and in vivo. The study also demonstrates that spheroids from GelMA-nanoclay hydrogels have increased stemness and sensitivity to anti-CSC compounds compared to traditional methods. This research is significant for facilitating effective CSC-targeting drug screening.
Review
Immunology
Zimo Jia, Jinlin Jia, Lihui Yao, Zhihan Li
Summary: The tumor microenvironment (TME) is a complex tissue entity composed of various cellular compartments, and exosomes carrying non-coding RNAs play a crucial role in the communication between tumor cells and the TME, regulating TME function and contributing to cancer development and progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Bai, Cheng Yuan, Wenjie Sun, Jianguo Zhang, Yuan Luo, Yanping Gao, Yangyi Li, Yan Gong, Conghua Xie
Summary: NEK2 plays a crucial role in the oncogenesis of non-small cell lung cancer, with its deficiency inhibiting tumor cell proliferation, migration, and invasion, as well as affecting macrophage polarization and angiogenesis in the tumor microenvironment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ting Deng, Yibo Hou, Gaoyang Lin, Chunyan Feng, Kewei Liu, Wenke Chen, Wei Wei, Laiqiang Huang, Xiaoyong Dai
Summary: Colorectal cancer (CRC) is a major cause of cancer-related deaths globally. Fibromodulin (FMOD) is a proteoglycan that plays a vital role in tumor growth and metastasis. This study found that FMOD is upregulated in CRC and associated with poor patient prognosis. A novel FMOD antagonist peptide, RP4, was developed and shown to inhibit CRC cell growth and metastasis, promote apoptosis, and affect the immune microenvironment. Mechanistically, RP4 blocked the Akt and Wnt/beta-catenin signaling pathways. FMOD is identified as a potential target for CRC treatment and RP4 as a potential clinical drug.
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
Review
Biochemistry & Molecular Biology
Naoki Asano, Akio Takeuchi, Akira Imatani, Masashi Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
Summary: In an aging society, it is crucial to study the role of Wnt signaling in aging of the gastrointestinal tract and aging-related carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
