Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rui Bai, Cheng Yuan, Wenjie Sun, Jianguo Zhang, Yuan Luo, Yanping Gao, Yangyi Li, Yan Gong, Conghua Xie
Summary: NEK2 plays a crucial role in the oncogenesis of non-small cell lung cancer, with its deficiency inhibiting tumor cell proliferation, migration, and invasion, as well as affecting macrophage polarization and angiogenesis in the tumor microenvironment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Jhalak Dholakia, Carly B. Scalise, Ashwini A. Katre, Whitney N. Goldsberry, Selene Meza-Perez, Troy D. Randall, Lyse A. Norian, Lea Novak, Rebecca C. Arend
Summary: The study showed that Wnt/beta-catenin pathway modulation increases MHC I expression and promotes tumor leukocytic infiltration, facilitating a pro-immune TME associated with decreased tumor burden. This intervention overcomes common tumor immune-evasion mechanisms and may render ovarian tumors susceptible to immunotherapy.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Satoshi Muto, Akio Enta, Yoshiyuki Maruya, Sho Inomata, Hikaru Yamaguchi, Hayato Mine, Hironori Takagi, Yuki Ozaki, Masayuki Watanabe, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Kazuyuki Hamada, Hiroyuki Suzuki
Summary: Lung cancer is a major cause of death globally. The standard treatment for advanced non-small-cell lung cancer (NSCLC) without certain gene mutations involves a combination of immunotherapy and chemotherapy or immunotherapy and another type of antibody. Although combination treatment can reduce disease progression, only about half of the patients respond long-term. Therefore, it is important to understand the mechanisms of resistance to immunotherapy. One potential mechanism is the Wnt/beta-catenin signaling pathway. This review summarizes the current knowledge on resistance mechanisms in NSCLC and other cancers, focusing on the role of Wnt/beta-catenin signaling. Therapeutic approaches to overcome these resistance mechanisms are also discussed.
Article
Cell Biology
Qilin Li, Ding Xia, Zhihua Wang, Bo Liu, Jing Zhang, Ping Peng, Qiujun Tang, Jie Dong, Juan Guo, Dong Kuang, Weimin Chen, Jing Mao, Qiuhui Li, Xin Chen
Summary: The study identified that circadian rhythm gene PER3 acts as a negative regulator in prostate cancer stem cells (PCSCs), controlling their stemness through the WNT/beta-catenin signaling pathway in the tumor microenvironment. PER3 downregulation is associated with enhanced tumor-initiating abilities, while PER3 overexpression suppresses tumorigenicity and colony-forming capacities in PCa cells, suggesting a potential novel therapeutic strategy for PCa patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hanne-Line Rabben, Goran Troseth Andersen, Magnus Kringstad Olsen, Anders Overby, Aleksandr Ianevski, Denis Kainov, Timothy Cragin Wang, Steinar Lundgren, Jon Erik Gronbech, Duan Chen, Chun-Mei Zhao
Summary: The study identified a link between neural signaling and tumor metabolism, proposing a therapeutic strategy targeting nerve-cancer metabolism which demonstrated efficacy in mouse models and feasibility in patients.
Article
Engineering, Biomedical
Xianquan Feng, Jialiang Zhang, Lina Wu, Wanjing Lin, Zhihong Liu, Xin Zhou, Yang Qi, Zhenzhen Chen, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Qian Zhang, Hongtao Song
Summary: This study evaluates the role of drug self-delivery nanocubes (ATO/PpIX-SMN) combined with anti-PD-L1 in TNBC treatment. The nanocubes enhance photodynamic therapy-induced immunogenic cell death and downregulate tumor signaling. Combined with anti-PD-L1, they promote dendritic cell maturation, increase CTL infiltration, reduce regulatory T cells, and activate the host immune system, effectively treating primary and distal tumors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
J. A. Wall, S. Meza-Perez, C. B. Scalise, A. Katre, A. Londono, W. J. Turbitt, T. Randall, L. A. Norian, R. C. Arend
Summary: This study evaluated the anti-tumor and immune-enhancing properties of the Wnt inhibitor CGX-1321 in ovarian cancer. Results showed that CGX-1321 significantly reduced tumor burden and increased CD8+ T cell infiltration. Although the addition of DKN-01 or anti-PD-1 therapies did not enhance the effects of CGX-1321, further investigation is needed to determine if CGX-1321 + DKN-01 combination treatment sensitizes pre-clinical ovarian cancer to ICB therapy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Immunology
Weifeng Xu, Caiyun Nie, Huifang Lv, BeiBei Chen, Jianzheng Wang, Saiqi Wang, Jing Zhao, Yunduan He, Xiaobing Chen
Summary: Based on molecular subtypes, this study classified hepatocellular carcinoma and explored the relationship between Wnt signaling and cancer development. The high Wnt subtype was found to be associated with immune suppression, poor prognosis, and low response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yang Tang, Maoyan Jiang, Anping Chen, Wendong Qu, Xu Han, Jiebin Zuo, Gang Xu, Yongxiang Song, Cheng Chen, Xixian Ke
Summary: The study demonstrated that LGK-974 regulates the polarization of TAMs, leading to inhibition of malignant behaviors in cancer cells. By modulating the functional markers of M1 and M2 macrophages and suppressing Wnt/beta-catenin signaling, LGK-974 altered the tumor microenvironment in lung cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Oncology
Stefan Koch
Summary: This article discusses the control of the Wnt pathway by FOX proteins, and the contribution of their interaction to cancer initiation and progression. Further research on FOX biology may lead to new targeted treatments for cancer.
Review
Oncology
Gui-Xian Zhu, Dian Gao, Zhao-Zhao Shao, Li Chen, Wen-Jie Ding, Qiong-Fang Yu
Summary: The unsatisfactory effect of chemotherapy in colorectal cancer is mainly due to the presence of highly metastatic tumor stem cells, regulation of non-coding RNAs, and the tumor microenvironment. The Wnt/beta-catenin signaling pathway plays a crucial role in mediating chemoresistance in CRC by impacting these factors.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
