The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections

Hepatic PPARα is critical in the metabolic adaptation to sepsis

(2019) Réjane Paumelle et al.   JOURNAL OF HEPATOLOGY

Macrophage nuclear receptors: Emerging key players in infectious diseases

(2019) Chrissy M. Leopold Wager et al.   PLoS Pathogens

CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses

(2019) Audrey Bernut et al.   Cell Reports

Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors

(2019) Yuuki Bamba et al.   BMC INFECTIOUS DISEASES

SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

(2019) Tae Sung Kim et al.   Autophagy

Mycobacterium tuberculosis and macrophage nuclear receptors: What we do and don't know

(2019) Chrissy M. Leopold Wager et al.   TUBERCULOSIS

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

(2019) Ning Liang et al.   Nature Communications

Non-tuberculous mycobacterial pulmonary disease

(2019) Steven Cowman et al.   EUROPEAN RESPIRATORY JOURNAL

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection

(2019) Radha Gopal et al.   Viruses-Basel

Incidence, comorbidities, and treatment patterns of nontuberculous mycobacterial infection in South Korea

(2019) Hye Ok Kim et al.   MEDICINE

Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis

(2018) Nisha Singh et al.   Autophagy

Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections

(2018) Jennifer R Honda et al.   CURRENT OPINION IN IMMUNOLOGY

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms

(2018) Kenneth C. Malcolm et al.   PLoS One

Involvement Of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammosome Activation, Against Pulmonary Infection with Pseudomosas Aeruginosa

(2018) Enrico Gugliandolo et al.   SHOCK

Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury

(2018) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-like receptor 2 prevents neutrophil-driven immunopathology during infection with Mycobacterium tuberculosis by curtailing CXCL5 production.

(2018) Archana Gopalakrishnan et al.   INFECTION AND IMMUNITY

Host Variability in NTM Disease: Implications for Research Needs

(2018) Colin Swenson et al.   Frontiers in Microbiology

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

(2017) Yi Sak Kim et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

(2016) Theodore S. Kapellos et al.   MEDIATORS OF INFLAMMATION

Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection

(2016) Gahl Levy et al.   Nature Chemical Biology

The distinct fate of smooth and roughMycobacterium abscessusvariants inside macrophages

(2016) Anne-Laure Roux et al.   Open Biology

Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking

(2016) Audrey Bernut et al.   PLoS Pathogens

NR1D1 amelioratesMycobacterium tuberculosisclearance through regulation of autophagy

(2015) Vemika Chandra et al.   Autophagy

The Treatment of Rapidly Growing Mycobacterial Infections

(2015) Shannon H. Kasperbauer et al.   CLINICS IN CHEST MEDICINE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Mycobacterium abscessus Morphotype Comparison in a Murine Model

(2015) Lindsay J. Caverly et al.   PLoS One

Therapeutic Effects of PPARαon Neuronal Death and Microvascular Impairment

(2015) Elizabeth P. Moran et al.   PPAR Research

Advances in the management of pulmonary disease due to Mycobacterium abscessus complex

(2014) W-J. Koh et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis

(2014) Geraldine Nouailles et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunological Markers of Lung Disease Due to Non-Tuberculous Mycobacteria

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Mycobacterium abscessus Induces a Limited Pattern of Neutrophil Activation That Promotes Pathogen Survival

(2013) Kenneth C. Malcolm et al.   PLoS One

Mycobacterial diseases and antitumour necrosis factor therapy in USA

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Gemfibrozil, a Lipid-lowering Drug, Increases Myelin Genes in Human Oligodendrocytes via Peroxisome Proliferator-activated Receptor-β

(2012) Malabendu Jana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence

(2011) N. Andreu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Significance of Differentiation ofMycobacterium massiliensefromMycobacterium abscessus

(2010) Won-Jung Koh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host Immune Response to Rapidly Growing Mycobacteria, an Emerging Cause of Chronic Lung Disease

(2010) Edward D. Chan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

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Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

(2009) R. Reich-Slotky et al.   JOURNAL OF BACTERIOLOGY

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

PPARs and the Cardiovascular System

(2008) Milton Hamblin et al.   ANTIOXIDANTS & REDOX SIGNALING