MicroRNAs as Emerging Regulators of Signaling in the Tumor Microenvironment

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

(2019) Ann-Christin Frank et al.   Nature Communications

Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles

(2019) Svetlana Tamkovich et al.   CURRENT MOLECULAR MEDICINE

Significant improvement of miRNA target prediction accuracy in large datasets using meta-strategy based on comprehensive voting and artificial neural networks

(2019) Bi Zhao et al.   BMC GENOMICS

Exosome: An Emerging Source of Biomarkers for Human Diseases

(2019) Li Xu et al.   CURRENT MOLECULAR MEDICINE

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

(2019) Li Yang et al.   Journal of Hematology & Oncology

MicroRNA‐425‐5p promotes breast cancer cell growth by inducing PI3K/AKT signaling

(2019) Li‐Feng Zhang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

MicroRNA—A Tumor Trojan Horse for Tumor-Associated Macrophages

(2019) Shahzad Nawaz Syed et al.   Cells

The biochemical basis of microRNA targeting efficacy

(2019) Sean E. McGeary et al.   SCIENCE

The Role of miRNAs in Virus-Mediated Oncogenesis

(2018) Zuzana Vojtechova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miRAW: A deep learning-based approach to predict microRNA targets by analyzing whole microRNA transcripts

(2018) Albert Pla et al.   PLoS Computational Biology

MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer

(2018) Jin’en Wu et al.   Frontiers in Immunology

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IMP1 3′ UTR shortening enhances metastatic burden in colorectal cancer

(2018) Sarah F Andres et al.   CARCINOGENESIS

Tumor microenvironment: Interactions and therapy

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase 1

(2017) Yiming Chen et al.   Molecular Medicine Reports

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level

(2017) Dong Wang et al.   NUCLEIC ACIDS RESEARCH

Upregulated microRNA-429 inhibits the migration of HCC cells by targeting TRAF6 through the NF-κB pathway

(2017) Peng Wang et al.   ONCOLOGY REPORTS

Disassembly of the Dying: Mechanisms and Functions

(2017) Georgia K. Atkin-Smith et al.   TRENDS IN CELL BIOLOGY

Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors

(2017) Deniz Mahmut Özata et al.   Cell Death & Disease

MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

(2017) Nana Li et al.   Cell Death & Disease

Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment

(2017) Maren Schoepp et al.   Cancers

MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway

(2017) Yuan Miao et al.   Scientific Reports

Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells

(2016) Xinfeng Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

miR‐10b expression in breast cancer stem cells supports self‐renewal through negative PTEN regulation and sustained AKT activation

(2016) Ivan Bahena‐Ocampo et al.   EMBO REPORTS

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Earliest hominin cancer: 1.7-million-year-old osteosarcoma from Swartkrans Cave, South Africa

(2016) Edward J. Odes et al.   SOUTH AFRICAN JOURNAL OF SCIENCE

Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease

(2016) Patrick S. Randolph-Quinney et al.   SOUTH AFRICAN JOURNAL OF SCIENCE

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function

(2016) Gerald J. Prud'homme et al.   Oncotarget

MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression

(2016) Steven W. Paugh et al.   PLoS Computational Biology

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

MiR-940 Inhibited Pancreatic Ductal Adenocarcinoma Growth by Targeting MyD88

(2015) Bin Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer

(2015) Young-Jun Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes and their roles in immune regulation and cancer

(2015) David W. Greening et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Non-coding RNA: what is functional and what is junk?

(2015) Alexander F. Palazzo et al.   Frontiers in Genetics

MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients

(2015) Loredan S. Niculescu et al.   PLoS One

RNAa in action: From the exception to the norm

(2015) Dan Guo et al.   RNA Biology

Transcriptional regulation mechanism mediated by miRNA–DNA•DNA triplex structure stabilized by Argonaute

(2014) Julia D. Toscano-Garibay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Driving glioblastoma growth by alternative polyadenylation

(2014) Ting Han et al.   CELL RESEARCH

NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells

(2014) Jian Zhang et al.   Journal of Translational Medicine

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3

(2014) Na Zhao et al.   Molecular Cancer

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

(2014) Chioniso P. Masamha et al.   NATURE

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MiR-99a Antitumor Activity in Human Breast Cancer Cells through Targeting of mTOR Expression

(2014) Yu Hu et al.   PLoS One

The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer

(2014) Charles J. d'Adhemar et al.   PLoS One

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

(2014) Fatiha Tabet et al.   Nature Communications

Characterization of Levels and Cellular Transfer of Circulating Lipoprotein-Bound MicroRNAs

(2013) Jasmin Wagner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer

(2013) JINDAN AN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Promoter RNA links transcriptional regulation of inflammatory pathway genes

(2013) Masayuki Matsui et al.   NUCLEIC ACIDS RESEARCH

A new role for microRNAs, as ligands of Toll-like receptors

(2013) Muller Fabbri et al.   RNA Biology

microRNAs are ligands of Toll-like receptors

(2013) X. Chen et al.   RNA

ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry

(2013) F. A. Karreth et al.   Cancer Discovery

Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties

(2012) Liang Meng Wee et al.   CELL

Alternative Cleavage and Polyadenylation during Colorectal Cancer Development

(2012) A. R. Morris et al.   CLINICAL CANCER RESEARCH

A quantitative atlas of polyadenylation in five mammals

(2012) Adnan Derti et al.   GENOME RESEARCH

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia

(2012) J. J. David Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-122 Inhibits Cell Proliferation and Tumorigenesis of Breast Cancer by Targeting IGF1R

(2012) Biyun Wang et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular miRNAs: the mystery of their origin and function

(2012) Andrey Turchinovich et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer

(2011) W. Shi et al.   CANCER RESEARCH

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

Up-regulation ofmiR-21Mediates Resistance to Trastuzumab Therapy for Breast Cancer

(2011) Chang Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways

(2011) Cecilia Scisciani et al.   JOURNAL OF HEPATOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK)

(2011) S Zhang et al.   ONCOGENE

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

(2011) Rujuan Dai et al.   Translational Research

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

Small RNA and transcriptional upregulation

(2011) Victoria Portnoy et al.   Wiley Interdisciplinary Reviews-RNA

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer

(2010) Shahana Majid et al.   CANCER

NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors

(2010) Vivian Y. Shin et al.   CARCINOGENESIS

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer

(2010) Konstantin J. Dedes et al.   EUROPEAN JOURNAL OF CANCER

Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB

(2010) Justin L. Mott et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-466l Upregulates IL-10 Expression in TLR-Triggered Macrophages by Antagonizing RNA-Binding Protein Tristetraprolin-Mediated IL-10 mRNA Degradation

(2010) F. Ma et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation

(2010) Tao Li et al.   NATURE IMMUNOLOGY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

(2010) Lucy Pigati et al.   PLoS One

Tumour-microenvironmental interactions: paths to progression and targets for treatment

(2010) Carol Box et al.   SEMINARS IN CANCER BIOLOGY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Down-regulation of dicer expression in ovarian cancer tissues

(2009) Georgios Pampalakis et al.   CLINICAL BIOCHEMISTRY

MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-κB1

(2009) Li-Min Guo et al.   FEBS Journal

Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression

(2009) Xiaoying Zhang et al.   HEPATOLOGY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

(2009) F. Bazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7

(2009) Simon Staubach et al.   PROTEOMICS

Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma

(2008) R. W. Chen et al.   BLOOD

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Ripples from neighbouring transcription

(2008) Miki Ebisuya et al.   NATURE CELL BIOLOGY

Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

(2008) D Bhaumik et al.   ONCOGENE

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE