Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

(2019) Netanel Tzarum et al.   Science Advances

VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design

(2019) Fang Chen et al.   Current Opinion in Virology

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

(2019) Masaru Kanekiyo et al.   NATURE IMMUNOLOGY

A nanoparticle-based HCV vaccine with enhanced potency

(2019) Yu Yan et al.   JOURNAL OF INFECTIOUS DISEASES

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

(2019) Zhen-Yong Keck et al.   PLoS Pathogens

Increases in Acute Hepatitis C Virus Infection Related to a Growing Opioid Epidemic and Associated Injection Drug Use, United States, 2004 to 2014

(2018) Jon E. Zibbell et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Designing a B Cell-Based Vaccine against a Highly Variable Hepatitis C Virus

(2018) Thomas R. Fuerst et al.   Frontiers in Microbiology

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

(2018) Mei-Le Keck et al.   Frontiers in Immunology

The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein

(2018) Netanel Tzarum et al.   Frontiers in Immunology

Hepatitis C Vaccines, Antibodies, and T Cells

(2018) Naglaa H. Shoukry   Frontiers in Immunology

HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design

(2018) Andrew I. Flyak et al.   Cell Host & Microbe

Interrogation of Antigen Display on Individual Vaccine Nanoparticles for Achieving Neutralizing Antibody Responses against Hepatitis C Virus

(2018) Joseph D. Bazzill et al.   NANO LETTERS

HIV-1 vaccine design through minimizing envelope metastability

(2018) Linling He et al.   Science Advances

The HIV-1 envelope glycoprotein structure: nailing down a moving target

(2017) Andrew B Ward et al.   IMMUNOLOGICAL REVIEWS

Native-like Env trimers as a platform for HIV-1 vaccine design

(2017) Rogier W. Sanders et al.   IMMUNOLOGICAL REVIEWS

Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope

(2017) Brian G. Pierce et al.   JOURNAL OF VIROLOGY

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

(2017) Shridhar Bale et al.   JOURNAL OF VIROLOGY

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers

(2017) Charles D. Morris et al.   mBio

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

(2016) Catherine Fauvelle et al.   Expert Review of Vaccines

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity

(2016) Jannick Prentoe et al.   HEPATOLOGY

Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals

(2016) Fabio Conti et al.   JOURNAL OF HEPATOLOGY

Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422

(2016) Annamaria Sandomenico et al.   JOURNAL OF VIROLOGY

Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen

(2016) Leopold Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

(2016) Leopold Kong et al.   Nature Communications

Hepatitis C Treatment and Barriers to Eradication

(2016) Monica A Konerman et al.   Clinical and Translational Gastroenterology

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

From non-A, non-B hepatitis to hepatitis C virus cure

(2015) Jean-Michel Pawlotsky et al.   JOURNAL OF HEPATOLOGY

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

(2015) Joyce K. Hu et al.   JOURNAL OF VIROLOGY

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis

(2015) Kaifan Dai et al.   mBio

Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding

(2015) Linling He et al.   Scientific Reports

Computational tools for epitope vaccine design and evaluation

(2015) Linling He et al.   Current Opinion in Virology

The past, present and future of neutralizing antibodies for hepatitis C virus

(2014) Jonathan K. Ball et al.   ANTIVIRAL RESEARCH

Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2

(2014) Abdul Ghafoor Khan et al.   NATURE

CD81 and Hepatitis C Virus (HCV) Infection

(2014) Lucie Fénéant et al.   Viruses-Basel

HCV transmission in industrialized countries and resource-constrained areas

(2013) Mark Thursz et al.   Nature Reviews Gastroenterology & Hepatology

The ins and outs of hepatitis C virus entry and assembly

(2013) Brett D. Lindenbach et al.   NATURE REVIEWS MICROBIOLOGY

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

(2013) L. Kong et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Advances in structure-based vaccine design

(2013) Daniel W Kulp et al.   Current Opinion in Virology

Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

(2012) Z. Keck et al.   JOURNAL OF VIROLOGY

Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1

(2012) L. Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

(2012) Natasha Kushnir et al.   VACCINE

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

(2012) Zhen-yong Keck et al.   PLoS Pathogens

Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations

(2011) Z.-Y. Keck et al.   JOURNAL OF VIROLOGY

Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial

(2011) Paul D Griffiths et al.   LANCET

New Insights into the HCV Quasispecies and Compartmentalization

(2011) Patrizia Farci   SEMINARS IN LIVER DISEASE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults

(2010) Sharon E. Frey et al.   VACCINE

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY