Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies

(2016) Catherine Fauvelle et al.   GASTROENTEROLOGY

Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus

(2016) Zhen-yong Keck et al.   JOURNAL OF VIROLOGY

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

(2015) Jannick Prentoe et al.   GUT

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

(2015) Yousef Alhammad et al.   JOURNAL OF VIROLOGY

Immunoglobulin with High-TiterIn VitroCross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

(2015) Jens Bukh et al.   JOURNAL OF VIROLOGY

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

(2015) Alexander Tarr et al.   Viruses-Basel

Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design

(2015) Leopold Kong et al.   Current Opinion in Virology

Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

(2014) William O. Osburn et al.   HEPATOLOGY

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

(2014) Thomas H.R. Carlsen et al.   HEPATOLOGY

Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins

(2014) D. Bankwitz et al.   JOURNAL OF VIROLOGY

Recombinant Hepatitis C Virus Envelope Glycoprotein Vaccine Elicits Antibodies Targeting Multiple Epitopes on the Envelope Glycoproteins Associated with Broad Cross-Neutralization

(2014) J. A. J.-X. Wong et al.   JOURNAL OF VIROLOGY

Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

(2013) Jannie Pedersen et al.   HEPATOLOGY

Virus-neutralizing antibodies to hepatitis C virus

(2013) A. Wahid et al.   JOURNAL OF VIRAL HEPATITIS

Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus

(2013) J. Prentoe et al.   JOURNAL OF VIROLOGY

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

(2013) John Lok Man Law et al.   PLoS One

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

(2013) L. Kong et al.   SCIENCE

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

(2013) Thomas Krey et al.   PLoS Pathogens

Three Different Functional Microdomains in the Hepatitis C Virus Hypervariable Region 1 (HVR1) Mediate Entry and Immune Evasion

(2012) Mo Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

(2012) Z. Keck et al.   JOURNAL OF VIROLOGY

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

(2012) Zhen-yong Keck et al.   PLoS Pathogens

In vivoevaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

(2011) Philip Meuleman et al.   HEPATOLOGY

Neutralizing Monoclonal Antibodies against Hepatitis C Virus E2 Protein Bind Discontinuous Epitopes and Inhibit Infection at a Postattachment Step

(2011) M. C. Sabo et al.   JOURNAL OF VIROLOGY

Hepatitis C Patient-Derived Glycoproteins Exhibit Marked Differences in Susceptibility to Serum Neutralizing Antibodies: Genetic Subtype Defines Antigenic but Not Neutralization Serotype

(2011) A. W. Tarr et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes

(2010) D. Bankwitz et al.   JOURNAL OF VIROLOGY

Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies

(2010) J. M. Gottwein et al.   JOURNAL OF VIROLOGY

Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization

(2010) J. Prentoe et al.   JOURNAL OF VIROLOGY

Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus

(2009) T. J. Broering et al.   JOURNAL OF VIROLOGY

Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain

(2008) J. Bukh et al.   JOURNAL OF VIROLOGY

Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

(2008) T. K. H. Scheel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA