Article
Medicine, General & Internal
Rui-Lin Ma, Yan Deng, Yan-Fang Wang, Shi-Yang Zhu, Xue-Song Ding, Ai-Jun Sun
Summary: The study demonstrated that once-weekly exenatide combined with MET was more effective than MET alone in overweight/obese women with PCOS, leading to weight reduction, improvement in BMI and waist circumference, and enhanced insulin sensitivity, with acceptable short-term side effects.
CHINESE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Medicine, General & Internal
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: The aim of this study was to determine if the androgen status modulates the impact of metformin on plasma prolactin levels in women. The results showed that the drug decreased total and monomeric prolactin and increased luteinizing hormone (LH) in control subjects. In women with polycystic ovary syndrome (PCOS), metformin reduced LH, LH/FSH ratio, testosterone, and free androgen index (FAI).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Xin Chen, Ying Lan, Lijie Yang, Yang Liu, Hongyu Li, Xinyun Zhu, Yuemeng Zhao, Caiyi Long, Mengjing Wang, Qingling Xie, Zhao Li, Jie Wu
Summary: This study evaluated the effect of acupuncture combined with metformin compared to metformin alone on the pregnancy rate of patients with polycystic ovary syndrome (PCOS). The results showed that acupuncture combined with metformin can significantly improve the pregnancy rate, ovulation rate, and insulin resistance in PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Aya Mousa, Kevin Huynh, Stacey J. Ellery, Boyd J. Strauss, Anju E. Joham, Barbora de Courten, Peter J. Meikle, Helena J. Teede
Summary: This study demonstrates that high levels of LPI(18:0) and low levels of DHA-containing lipids are associated with key metabolic risk factors in women with and without polycystic ovary syndrome (PCOS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Meili Cai, Xiaowen Shao, Feng Xing, Yuqin Zhang, Xinyu Gao, Qiongjing Zeng, Diliqingna Dilimulati, Shen Qu, Manna Zhang
Summary: The study demonstrates that canagliflozin is not inferior to metformin in improving insulin resistance in PCOS patients, with significant benefits in improving menstrual pattern, reducing body weight and total fat mass, and decreasing triglyceride levels.
DIABETES OBESITY & METABOLISM
(2022)
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Dan Tian, Wei Chen, Qing Xu, Xiaoyu Li, Qianzhou Lv
Summary: Liraglutide treatment significantly improves waist circumference, BMI, weight, and insulin resistance in obese women with PCOS, with a potential effect on FSH and LH but with high heterogeneity.
Review
Obstetrics & Gynecology
Suleyman N. Sendur, Bulent O. Yildiz
Summary: The clinical presentation and treatment outcomes of patients with PCOS vary significantly among different ethnicities, including differences in hirsutism, hormone levels, body weight, and insulin resistance. These variations show distinct differences among ethnic groups in the clinical phenotype of PCOS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Ki-Jin Ryu, Min Sun Kim, Hyun Kyun Kim, Yong Jin Kim, Kyong Wook Yi, Jung Ho Shin, Jun Young Hur, Tak Kim, Hyuntae Park
Summary: This study found that PCOS is independently associated with an increased incidence of T2DM in Korean women, regardless of obesity status. Screening for T2DM should be considered for Korean women with PCOS.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Tianjiao Pei, Xin Huang, Ying Long, Changling Duan, Tingting Liu, Yujing Li, Wei Huang
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Changling Duan, Tianjiao Pei, Yujing Li, Qi Cao, Hanxiao Chen, Jing Fu
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2020)
Article
Health Care Sciences & Services
Jing An, Hui Zhou, Ting Yang, Changling Duan, Chenyi Bao, Chun Wan, Yongchun Shen, Fuqiang Wen
Summary: The study suggests that psychological factors, such as active coping, disease perception, anxiety and depression, are closely associated with the daily activities and quality of life of COPD patients.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Weiyu Liu, Shaojun Xu, Shuangqin Liang, Changling Duan, Zhilan Xu, Le Zhao, Feifei Wen, Qiuyan Li, Yikui Li, Jinyan Zhang
Summary: Allicin has been found to improve vascular and cardiac remodeling in Spontaneous Hypertension Rats (SHRs), potentially through regulating calcium homeostasis and inhibiting inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Tianjiao Pei, Chang Liu, Tingting Liu, Li Xiao, Bin Luo, Jing Tan, Xueying Li, Guojun Zhou, Changling Duan, Wei Huang