Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

(2019) Hannah L. Turner et al.   PLOS BIOLOGY

The Role of M2e in the Development of Universal Influenza Vaccines

(2019) Xavier Saelens   JOURNAL OF INFECTIOUS DISEASES

“Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design

(2019) Yan Wu et al.   CELL

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

(2019) Sandhya Bangaru et al.   CELL

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism

(2019) Akiko Watanabe et al.   CELL

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

(2019) Goran Bajic et al.   Cell Host & Microbe

Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus

(2019) Zhang et al.   Viruses-Basel

Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS

(2019) Cristina Puchades et al.   Scientific Reports

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viroporins in the Influenza Virus

(2019) Janet To et al.   Cells

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

(2019) Kenta Matsuda et al.   Science Immunology

Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers

(2018) Dibyendu Kumar Das et al.   CELL

Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein

(2018) James B. Munro et al.   CURRENT HIV RESEARCH

Structure of the Lassa virus glycan shield provides a model for immunological resistance

(2018) Yasunori Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

(2018) Muriel Lavie et al.   Frontiers in Immunology

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

(2017) Donald D. Raymond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses

(2017) Chenguang Shen et al.   Science Translational Medicine

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

(2017) Nicholas C. Wu et al.   Nature Communications

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

Tackling influenza with broadly neutralizing antibodies

(2017) Davide Corti et al.   Current Opinion in Virology

Single-Domain Antibodies As Therapeutics against Human Viral Diseases

(2017) Yanling Wu et al.   Frontiers in Immunology

A Broadly Reactive Human Anti-hemagglutinin Stem Monoclonal Antibody That Inhibits Influenza A Virus Particle Release

(2017) Seiya Yamayoshi et al.   EBioMedicine

Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form

(2017) Jong Hyeon Seok et al.   Scientific Reports

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Unmasking Stem-Specific Neutralizing Epitopes by Abolishing N-Linked Glycosylation Sites of Influenza Virus Hemagglutinin Proteins for Vaccine Design

(2016) Wen-Chun Liu et al.   JOURNAL OF VIROLOGY

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

(2016) Jiwon Lee et al.   NATURE MEDICINE

Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein

(2016) Marion Russier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion

(2016) Natalie Garcia et al.   Viruses-Basel

Implications of broadly neutralizing antibodies in the development of a universal influenza vaccine

(2016) Alice Cho et al.   Current Opinion in Virology

Emerging influenza viruses and the prospect of a universal influenza virus vaccine

(2015) Florian Krammer   Biotechnology Journal

H5N1 Vaccine–Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem

(2015) Adam K. Wheatley et al.   JOURNAL OF IMMUNOLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Dynamic Changes during Acid-Induced Activation of Influenza Hemagglutinin

(2015) Natalie K. Garcia et al.   STRUCTURE

Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity

(2015) Pierre-Louis Hervé et al.   VIROLOGY

Emerging influenza viruses and the prospect of a universal influenza virus vaccine

(2015) Florian Krammer   Biotechnology Journal

Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China

(2014) Hua Ding et al.   BMC INFECTIOUS DISEASES

Broad Protection against Avian Influenza Virus by Using a Modified Vaccinia Ankara Virus Expressing a Mosaic Hemagglutinin Gene

(2014) A. Kamlangdee et al.   JOURNAL OF VIROLOGY

Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques

(2014) N. W. Florek et al.   JOURNAL OF VIROLOGY

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

A Broadly Neutralizing Human Monoclonal Antibody Directed against a Novel Conserved Epitope on the Influenza Virus H3 Hemagglutinin Globular Head

(2014) E. Benjamin et al.   JOURNAL OF VIROLOGY

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

(2014) Peter S. Lee et al.   Nature Communications

Broadly neutralizing antibodies against influenza viruses

(2013) Nick S. Laursen et al.   ANTIVIRAL RESEARCH

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

An overview of the recent outbreaks of the avian-origin influenza A (H7N9) virus in the human

(2013) Ren-Bin Tang et al.   Journal of the Chinese Medical Association

Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

(2013) C. Dreyfus et al.   JOURNAL OF VIROLOGY

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization

(2013) Boerries Brandenburg et al.   PLoS One

Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities

(2013) Xueyong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism

(2013) Xiaoman Sun et al.   Cell Reports

Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses

(2012) J. C. Krause et al.   JOURNAL OF VIROLOGY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient

(2012) Weibin Hu et al.   VIROLOGY

The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy

(2011) A. B. Bohn et al.   EUROPEAN JOURNAL OF NEUROLOGY

Vaccination with Different M2e Epitope Densities Confers Partial Protection against H5N1 Influenza A Virus Challenge in Chickens

(2011) Xintao Zhang et al.   INTERVIROLOGY

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5

(2011) N. Ohshima et al.   JOURNAL OF VIROLOGY

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing B cell capture of cognate antigen from follicular dendritic cells

(2009) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

(2009) R. M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses

(2009) Reiko Yoshida et al.   PLoS Pathogens