Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS

Investigating Protein-Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

(2018) Walter Becker et al.   CHEMPHYSCHEM

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

(2018) Nick S. Laursen et al.   SCIENCE

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

(2017) Glenn R. Masson et al.   Expert Opinion on Drug Discovery

The HIV-1 envelope glycoprotein structure: nailing down a moving target

(2017) Andrew B Ward et al.   IMMUNOLOGICAL REVIEWS

Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part

(2017) Esben Trabjerg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent peptidic fusion inhibitors of influenza virus

(2017) Rameshwar U. Kadam et al.   SCIENCE

Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

(2016) Martyna Prądzińska et al.   AMINO ACIDS

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

(2016) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Computational methods and challenges in hydrogen/deuterium exchange mass spectrometry

(2016) Jürgen Claesen et al.   MASS SPECTROMETRY REVIEWS

Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding

(2016) Henry Memczak et al.   PLoS One

Passive immunization for influenza through antibody therapies, a review of the pipeline, challenges and potential applications

(2016) Erin Sparrow et al.   VACCINE

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

(2016) Merika Treants Koday et al.   PLoS Pathogens

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

(2015) John R. Engen et al.   Annual Review of Analytical Chemistry

Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity

(2015) Feng Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Changes during Acid-Induced Activation of Influenza Hemagglutinin

(2015) Natalie K. Garcia et al.   STRUCTURE

Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer

(2015) Leopold Kong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

(2014) David P Marciano et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry

(2013) A. M. Sevy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization

(2013) Boerries Brandenburg et al.   PLoS One

Hydrogen Exchange Mass Spectrometry: Are We Out of the Quicksand?

(2012) Roxana E. Iacob et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Simultaneous Reduction and Digestion of Proteins with Disulfide Bonds for Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry

(2010) Hui-Min Zhang et al.   ANALYTICAL CHEMISTRY

Protein-peptide affinity determination using an H/D exchange dilution strategy: Application to antigen-antibody interactions

(2010) Tingting Tu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies

(2008) A. K. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA