Innate Immune Sensing by Cells of the Adaptive Immune System

Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

(2019) Livia Silva Araújo Passos et al.   Frontiers in Immunology

Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice

(2019) Sasha Silva‐Barrios et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses

(2019) Kelsey Roe et al.   PLoS One

Nucleic acid sensing activates the innate cytosolic surveillance pathway and promotes parasite survival in visceral leishmaniasis

(2019) Sushmita Das et al.   Scientific Reports

Pro-Cellular Exhaustion Markers are Associated with Splenic Microarchitecture Disorganization and Parasite Load in Dogs with Visceral Leishmaniasis

(2019) Tainã Luís de Souza et al.   Scientific Reports

Antiviral Adaptor MAVS Promotes Murine Lupus With a B Cell Autonomous Role

(2019) Wenxiang Sun et al.   Frontiers in Immunology

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

(2018) Alan Bénard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Deadly Dance of B Cells with Trypanosomatids

(2018) Sasha Silva-Barrios et al.   TRENDS IN PARASITOLOGY

IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection

(2018) Aymeric Fabié et al.   Cell Reports

Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients

(2018) Nathalie de Sena Pereira et al.   PLoS Neglected Tropical Diseases

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

(2018) Toru Uchimura et al.   IMMUNITY

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

B Cell–Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses

(2018) Melissa M. Walker et al.   JOURNAL OF IMMUNOLOGY

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

(2017) Silvia Cerboni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

(2017) Bridget Larkin et al.   JOURNAL OF IMMUNOLOGY

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy

(2017) Jian Ye et al.   JOURNAL OF IMMUNOLOGY

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure

(2017) Anna M. Gram et al.   MOLECULAR IMMUNOLOGY

Participation of TLR2 and TLR4 in Cytokines Production by Patients with Symptomatic and Asymptomatic Chronic Chagas Disease

(2017) L. D. Mendes da Silva et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes

(2017) Claudia Loetsch et al.   Cell Reports

Immunoregulatory mechanisms in Chagas disease: modulation of apoptosis in T-cell mediated immune responses

(2016) Ana Thereza Chaves et al.   BMC INFECTIOUS DISEASES

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

In vivoandin vitrophagocytosis ofLeishmania (Leishmania) amazonensispromastigotes by B-1 cells

(2016) M. M. Geraldo et al.   PARASITE IMMUNOLOGY

Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia

(2016) Sasha Silva-Barrios et al.   Cell Reports

Cytosolic Innate Immune Sensing and Signaling upon Infection

(2016) Lilliana Radoshevich et al.   Frontiers in Microbiology

STING Negatively Regulates Double-Stranded DNA-Activated JAK1-STAT1 Signaling via SHP-1/2 in B Cells

(2015) Guanjun Dong et al.   MOLECULES AND CELLS

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection

(2014) A. H. Rahman et al.   JOURNAL OF IMMUNOLOGY

The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

(2014) M. Fukata et al.   JOURNAL OF IMMUNOLOGY

MyD88-Dependent Pathway in T Cells Directly Modulates the Expansion of Colitogenic CD4+ T Cells in Chronic Colitis

(2014) T. Tomita et al.   JOURNAL OF IMMUNOLOGY

B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

(2014) Chetna Soni et al.   JOURNAL OF IMMUNOLOGY

Activation of the RIG-I Pathway during Influenza Vaccination Enhances the Germinal Center Reaction, Promotes T Follicular Helper Cell Induction, and Provides a Dose-Sparing Effect and Protective Immunity

(2014) R. R. Kulkarni et al.   JOURNAL OF VIROLOGY

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Nucleic acid sensing by T cells initiates Th2 cell differentiation

(2014) Takayuki Imanishi et al.   Nature Communications

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids

(2012) Zeinab Abdullah et al.   EMBO JOURNAL

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

(2011) Seon Hee Chang et al.   IMMUNITY

Requirement of UNC93B1 Reveals a Critical Role for TLR7 in Host Resistance to Primary Infection with Trypanosoma cruzi

(2011) B. C. Caetano et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

TLR1/2, TLR7, and TLR9 Signals Directly Activate Human Peripheral Blood Naive and Memory B Cell Subsets to Produce Cytokines, Chemokines, and Hematopoietic Growth Factors

(2010) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

(2010) José M. González-Navajas et al.   JOURNAL OF CLINICAL INVESTIGATION

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

The contribution of direct TLR signaling to T cell responses

(2009) Adeeb H. Rahman et al.   IMMUNOLOGIC RESEARCH

Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production

(2009) Marcus Dorner et al.   IMMUNOLOGY

Murine B Cell Response to TLR7 Ligands Depends on an IFN-  Feedback Loop

(2009) N. M. Green et al.   JOURNAL OF IMMUNOLOGY

Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection

(2009) A.-D. C. Chessler et al.   JOURNAL OF IMMUNOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

(2009) Donna L Thibault et al.   ARTHRITIS RESEARCH & THERAPY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

T cell expression of MyD88 is required for resistance to Toxoplasma gondii

(2008) D. F. LaRosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA