Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Sex differences in immunity

(2019) Hanna Lotter et al.   Seminars in Immunopathology

Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis in Drosophila

(2019) Omera B. Matoo et al.   GENETICS

Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster

(2019) Tiina S. Salminen et al.   G3-Genes Genomes Genetics

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

(2019) Mark Austin Hanson et al.   eLife

Mitochondrial DNA replication in mammalian cells: overview of the pathway

(2018) Maria Falkenberg   Essays in Biochemistry

Age and immunity: What is “immunosenescence”?

(2018) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Mitochondrial dysfunction and infection generate immunity-fecundity tradeoffs in Drosophila

(2018) Justin L Buchanan et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism

(2018) Senta M. Kapnick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

The Drosophila Dot Chromosome: Where Genes Flourish Amidst Repeats

(2018) Nicole C. Riddle et al.   GENETICS

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

(2018) Colby L. Samstag et al.   PLoS Genetics

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

Mitochondrial energy generation disorders: genes, mechanisms and clues to pathology

(2017) Ann E. Frazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

(2017) Tiina S. Salminen et al.   MITOCHONDRION

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Recent Advances in Mitochondrial Aminoacyl-tRNA Synthetases and Disease

(2017) Marie Sissler et al.   TRENDS IN MOLECULAR MEDICINE

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

(2017) Chao Tian et al.   Nature Communications

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Cellular immune defenses of Drosophila melanogaster

(2016) Brendon Parsons et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Sex-specific mitonuclear epistasis and the evolution of mitochondrial bioenergetics, ageing, and life history in seed beetles

(2016) Mirko Đorđević et al.   EVOLUTION

Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila

(2016) Jim A. Mossman et al.   GENETICS

Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing

(2016) E Immonen et al.   HEREDITY

Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies

(2016) J. N. Wolff et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

The genetics and pathology of mitochondrial disease

(2016) Charlotte L Alston et al.   JOURNAL OF PATHOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection

(2016) Ines Anderl et al.   PLoS Pathogens

Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila

(2016) Jim A. Mossman et al.   GENETICS

Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth

(2016) Esko Kemppainen et al.   PLoS One

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Single Nucleotides in the mtDNA Sequence Modify Mitochondrial Molecular Function and Are Associated with Sex-Specific Effects on Fertility and Aging

(2015) M. Florencia Camus et al.   CURRENT BIOLOGY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Within-population genetic effects of mtDNA on metabolic rate inDrosophila subobscura

(2015) Z. Kurbalija Novičić et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Complex mitonuclear interactions and metabolic costs of mating in male seed beetles

(2015) E. Immonen et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

(2015) Anna Maria D'Erchia et al.   MITOCHONDRION

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

(2015) Paul J. McLaren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial replacement therapy in reproductive medicine

(2015) Don P. Wolf et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

The Drosophila Imd Signaling Pathway

(2014) H. Myllymaki et al.   JOURNAL OF IMMUNOLOGY

Individual performance in relation to cytonuclear discordance in a northern contact zone between long-toed salamander (Ambystoma macrodactylum) lineages

(2014) Julie A. Lee-Yaw et al.   MOLECULAR ECOLOGY

The influence of mitonuclear genetic variation on personality in seed beetles

(2014) H. Lovlie et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Eukaryotic Origins: How and When Was the Mitochondrion Acquired?

(2014) A. M. Poole et al.   Cold Spring Harbor Perspectives in Biology

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

(2013) Carla Giordano et al.   BRAIN

Optimized breeding strategies for multiple trait integration: I. Minimizing linkage drag in single event introgression

(2013) Ting Peng et al.   MOLECULAR BREEDING

Mitochondrial aminoacyl-tRNA synthetases in human disease

(2013) Svetlana Konovalova et al.   MOLECULAR GENETICS AND METABOLISM

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis

(2013) T. Bender et al.   Cold Spring Harbor Perspectives in Biology

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

(2013) Colin D. Meiklejohn et al.   PLoS Genetics

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

A model 450 million years in the making: zebrafish and vertebrate immunity

(2012) S. A. Renshaw et al.   Disease Models & Mechanisms

A Cytoplasmic Suppressor of a Nuclear Mutation Affecting Mitochondrial Functions in Drosophila

(2012) S. Chen et al.   GENETICS

Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster

(2012) C.C. Correa et al.   MITOCHONDRION

Genome-wide association study indicates two novel resistance loci for severe malaria

(2012) Christian Timmann et al.   NATURE

Mitochondria: commanders of innate immunity and disease?

(2011) Suzanne M Cloonan et al.   CURRENT OPINION IN IMMUNOLOGY

Immune cell transdifferentiation: a complex crosstalk between circulating immune cells and the haematopoietic niche

(2011) Marie Meister et al.   EMBO REPORTS

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA transcription regulation and nucleoid organization

(2011) Adriana P. Rebelo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype

(2011) W.C. Aw et al.   MITOCHONDRION

Mitochondrial–Nuclear Interactions and Accelerated Compensatory Evolution: Evidence from the Primate Cytochrome c Oxidase Complex

(2011) Naoki Osada et al.   MOLECULAR BIOLOGY AND EVOLUTION

MITOCHONDRIAL-NUCLEAR EPISTASIS AFFECTS FITNESS WITHIN SPECIES BUT DOES NOT CONTRIBUTE TO FIXED INCOMPATIBILITIES BETWEEN SPECIES OF DROSOPHILA

(2010) Kristi L. Montooth et al.   EVOLUTION

Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells

(2010) Sudip Mandal et al.   STEM CELLS

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Stress and immunity in wild vertebrates: Timing is everything

(2009) Lynn B. Martin   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges

(2009) Johannes N. Spelbrink   IUBMB LIFE

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice

(2009) Mariola Kulawiec et al.   JOURNAL OF HUMAN GENETICS

Mitochondrial gene replacement in primate offspring and embryonic stem cells

(2009) Masahito Tachibana et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

The role of mitochondria in cellular defense against microbial infection

(2009) Damien Arnoult et al.   SEMINARS IN IMMUNOLOGY

Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background

(2008) David J. Clancy   AGING CELL

The evolution of RNAi as a defence against viruses and transposable elements

(2008) D. J Obbard et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes

(2008) H. Xu et al.   SCIENCE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

The Spectrum of Mitochondrial Mutation Differs across Species

(2008) Kristi L Montooth et al.   PLOS BIOLOGY