Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Growth inhibition in Raphidocelis subcapita – Evidence of nanospecific toxicity of silver nanoparticles

(2019) Merethe Kleiven et al.   CHEMOSPHERE

The comet assay applied to HepG2 liver spheroids

(2019) Elisabeth Elje et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Distribution of SiO2 nanoparticles in 3D liver microtissues

(2019) Jana Fleddermann et al.   International Journal of Nanomedicine

Three-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay

(2019) Marion Mandon et al.   Scientific Reports

A review of cardiovascular toxicity of TiO2, ZnO and Ag nanoparticles (NPs)

(2018) Yi Cao et al.   BIOMETALS

Characterizing the behavior, uptake, and toxicity of NM300K silver nanoparticles in Caenorhabditis elegans

(2018) Merethe Kleiven et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents

(2018) Anna Kędziora et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments

(2018) Claudia Conte et al.   JOURNAL OF CONTROLLED RELEASE

A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies

(2018) Ume-Kulsoom Shah et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility

(2018) Kerstin Reisinger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment

(2018) Jonathan A. Kyffin et al.   TOXICOLOGY IN VITRO

Characterization and reproducibility of HepG2 hanging drop spheroids toxicology in vitro

(2018) Tracey Hurrell et al.   TOXICOLOGY IN VITRO

A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives

(2018) Mahmuda Akter et al.   Journal of Advanced Research

Cytotoxicity and global transcriptional responses induced by zinc oxide nanoparticles NM 110 in PMA-differentiated THP-1 cells

(2018) Ramia Safar et al.   TOXICOLOGY LETTERS

Silver (nano)materials cause genotoxicity in Enchytraeus crypticus , as determined by the comet assay

(2017) Vera L. Maria et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Antibacterial properties and toxicity from metallic nanomaterials

(2017) Gina Vimbela et al.   International Journal of Nanomedicine

Review of the effects of manufactured nanoparticles on mammalian target organs

(2017) Tianshu Wu et al.   JOURNAL OF APPLIED TOXICOLOGY

Cytotoxic effects of nanosilver are highly dependent on the chloride concentration and the presence of organic compounds in the cell culture media

(2017) Jean-Pierre Kaiser et al.   JOURNAL OF NANOBIOTECHNOLOGY

Size-Dependent Protein–Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona

(2016) Jordi Piella et al.   BIOCONJUGATE CHEMISTRY

Liquid-based three-dimensional tumor models for cancer research and drug discovery

(2016) Stephanie L Ham et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis

(2016) Yinghua Li et al.   International Journal of Nanomedicine

Oxidative dissolution of silver nanoparticles: A new theoretical approach

(2016) Zbigniew Adamczyk et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo

(2016) Houmam Kafa et al.   JOURNAL OF CONTROLLED RELEASE

Nano-TiO2penetration of oral mucosa:in vitroanalysis using 3D organotypic human buccal mucosa models

(2016) Victoria Konstantinova et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

In vitrogenotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment

(2016) Naouale El Yamani et al.   MUTAGENESIS

Critical review of the current and future challenges associated with advancedin vitrosystems towards the study of nanoparticle (secondary) genotoxicity

(2016) Stephen J. Evans et al.   MUTAGENESIS

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro

(2016) Monika Dubiak-Szepietowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High throughput toxicity screening and intracellular detection of nanomaterials

(2016) Andrew R. Collins et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Progress and future of in vitro models to study translocation of nanoparticles

(2015) Hedwig M. Braakhuis et al.   ARCHIVES OF TOXICOLOGY

Toxicology of nanosized titanium dioxide: an update

(2015) Xiaochen Zhang et al.   ARCHIVES OF TOXICOLOGY

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

(2015) Hamed Arami et al.   CHEMICAL SOCIETY REVIEWS

Suitability of human and mammalian cells of different origin for the assessment of genotoxicity of metal and polymeric engineered nanoparticles

(2015) Hilary Cowie et al.   Nanotoxicology

Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

(2015) Amna Sirelkhatim et al.   Nano-Micro Letters

Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

(2015) Amna Sirelkhatim et al.   Nano-Micro Letters

Lung Injury Induced by TiO2 Nanoparticles Depends on Their Structural Features: Size, Shape, Crystal Phases, and Surface Coating

(2014) Jiangxue Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular toxicity mechanism of nanosilver

(2014) Danielle McShan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

(2014) Ali Kermanizadeh et al.   Particle and Fibre Toxicology

Nanoparticle exposure in animals can be visualized in the skin and analysed via skin biopsy

(2014) Edward A. Sykes et al.   Nature Communications

The predominant species of ionic silver in biological media is colloidally dispersed nanoparticulate silver chloride

(2014) K. Loza et al.   RSC Advances

Comet assay to measure DNA repair: approach and applications

(2014) Amaya Azqueta et al.   Frontiers in Genetics

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Interactive threats of nanoparticles to the biological system

(2013) Ruchi Roy et al.   IMMUNOLOGY LETTERS

Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles

(2013) Hermann Frieboes et al.   International Journal of Nanomedicine

Bioavailability of silver nanoparticles and ions: from a chemical and biochemical perspective

(2013) R. Behra et al.   Journal of the Royal Society Interface

Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cellsin vitro: A comparative review

(2013) Angela Ivask et al.   Nanotoxicology

Titanium dioxide nanoparticles: a review of current toxicological data

(2013) Hongbo Shi et al.   Particle and Fibre Toxicology

Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications

(2013) Bogumiła Reidy et al.   Materials

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance

(2012) Bing Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effects of water chemistry on the dissolution of ZnO nanoparticles and their toxicity to Escherichia coli

(2012) Mei Li et al.   ENVIRONMENTAL POLLUTION

Titanium Dioxide Nanoparticles in Food and Personal Care Products

(2012) Alex Weir et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Reactivity of inorganic nanoparticles in biological environments: insights into nanotoxicity mechanisms

(2012) E Casals et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

In vitroassessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers

(2012) Ali Kermanizadeh et al.   Nanotoxicology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Solubility of nano-zinc oxide in environmentally and biologically important matrices

(2011) Robert B. Reed et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

(2011) Vyom Sharma et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Rapid translocation of nanoparticles from the lung airspaces to the body

(2010) Hak Soo Choi et al.   NATURE BIOTECHNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

(2009) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivity of engineered inorganic nanoparticles and carbon nanostructures in biological media

(2008) Neus G. Bastús et al.   Nanotoxicology

Monolayer and Spheroid Culture of Human Liver Hepatocellular Carcinoma Cell Line Cells Demonstrate Distinct Global Gene Expression Patterns and Functional Phenotypes

(2008) Tammy T. Chang et al.   TISSUE ENGINEERING PART A