A Whole Genome Re-Sequencing Based GWA Analysis Reveals Candidate Genes Associated with Ivermectin Resistance in Haemonchus contortus

The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes

(2019) Cécile Ménez et al.   PLoS Pathogens

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

(2019) Mohammed Atif et al.   PLoS Pathogens

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

(2019) Stephen R. Doyle et al.   BMC GENOMICS

Genome-wide Approaches to Investigate Anthelmintic Resistance

(2019) Stephen R. Doyle et al.   TRENDS IN PARASITOLOGY

Analysis of genome-wide SNPs based on 2b-RAD sequencing of pooled samples reveals signature of selection in different populations of Haemonchus contortus

(2019) Sawar Khan et al.   JOURNAL OF BIOSCIENCES

WormBase: a modern Model Organism Information Resource

(2019) Todd W Harris et al.   NUCLEIC ACIDS RESEARCH

The global diversity of Haemonchus contortus is shaped by human intervention and climate

(2019) G. Sallé et al.   Nature Communications

Microsatellite analysis reveals extensive gene flow, and lack of population structure in the farm populations of Haemonchus contortus in northern China

(2019) Sawar Khan et al.   PARASITOLOGY INTERNATIONAL

OUP accepted manuscript

(2018)   BIOINFORMATICS

A method for single pair mating in an obligate parasitic nematode

(2018) Neil D. Sargison et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

(2018) Alexandra Blanchard et al.   PLoS Pathogens

A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry

(2017) Stephen R Doyle et al.   Genome Biology and Evolution

Mutations on M3 helix of Plutella xylostella glutamate-gated chloride channel confer unequal resistance to abamectin by two different mechanisms

(2017) Xingliang Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation

(2017) I-Shan Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

WormBase ParaSite − a comprehensive resource for helminth genomics

(2017) Kevin L. Howe et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus

(2017) Xiaoping Luo et al.   Parasites & Vectors

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

(2017) Stephen R. Doyle et al.   PLoS Neglected Tropical Diseases

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

(2017) Mohammed Atif et al.   PLoS Pathogens

Comparison of constitutive and thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage larvae of Haemonchus contortus isolates with different drug susceptibility identifies one gene with high constitutive expression in a multi-resistant isolate

(2017) Esra Yilmaz et al.   International Journal for Parasitology-Drugs and Drug Resistance

Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis elegans

(2016) Cécile Ménez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus

(2016) Andrew M. Rezansoff et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Haemonchus contortus: the then and now, and where to from here?

(2016) David L. Emery et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6years of macrocyclic lactone use

(2016) Roz Laing et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers

(2016) Fangyuan Yin et al.   Parasites & Vectors

Two benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene predominate in Haemonchus contortus populations from eight regions in China

(2016) Zongze Zhang et al.   International Journal for Parasitology-Drugs and Drug Resistance

Effects of in vitro exposure to ivermectin and levamisole on the expression patterns of ABC transporters in Haemonchus contortus larvae

(2016) Ali Raza et al.   International Journal for Parasitology-Drugs and Drug Resistance

NHR-176 regulatescyp-35d1to control hydroxylation-dependent metabolism of thiabendazole inCaenorhabditis elegans

(2015) Laura M. Jones et al.   BIOCHEMICAL JOURNAL

The cytochrome P450 family in the parasitic nematode Haemonchus contortus

(2015) Roz Laing et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Widespread anthelmintic resistance in European farmed ruminants: a systematic review

(2015) H. Rose et al.   VETERINARY RECORD

Ivermectin exposure leads to up-regulation of detoxification genes in vitro and in vivo in mice

(2014) Mélanie Albérich et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A dyf-7 haplotype causes sensory neuron defects and is associated with macrocyclic lactone resistance worldwide in the nematode parasite Haemonchus contortus

(2014) Ludmel Urdaneta-Marquez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

(2014) Andrew C. Kotze et al.   International Journal for Parasitology-Drugs and Drug Resistance

3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR

(2013) Baojian Wu et al.   DRUG DISCOVERY TODAY

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

Population genomics from pool sequencing

(2013) Luca Ferretti et al.   MOLECULAR ECOLOGY

Genetic variability within and among Haemonchus contortus isolates from goats and sheep in China

(2013) Fanyuan Yin et al.   Parasites & Vectors

Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance - an Australian perspective

(2013) Florian Roeber et al.   Parasites & Vectors

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

(2013) J.-P. David et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Adaptive and Specialised Transcriptional Responses to Xenobiotic Stress in Caenorhabditis elegans Are Regulated by Nuclear Hormone Receptors

(2013) Laura M. Jones et al.   PLoS One

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

(2013) Roz Laing et al.   GENOME BIOLOGY

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

(2013) Erich M Schwarz et al.   GENOME BIOLOGY

Avermectin Use in Aquaculture

(2012) Tor E. Horsberg   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

(2012) W. Dermauw et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

(2012) R. Ghosh et al.   SCIENCE

Introgression of Ivermectin Resistance Genes into a Susceptible Haemonchus contortus Strain by Multiple Backcrossing

(2012) Elizabeth Redman et al.   PLoS Pathogens

Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression

(2012) Mercedes Lloberas et al.   International Journal for Parasitology-Drugs and Drug Resistance

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(2011) R. Kofler et al.   BIOINFORMATICS

Advances in Human Cytochrome P450 and Personalized Medicine

(2011) Qi Chen et al.   CURRENT DRUG METABOLISM

Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus

(2011) Sally M. Williamson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

An inconvenient truth: Global worming and anthelmintic resistance

(2011) Ray M. Kaplan et al.   VETERINARY PARASITOLOGY

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

(2011) Mike Y. Osei-Atweneboana et al.   PLoS Neglected Tropical Diseases

Ion channels and receptor as targets for the control of parasitic nematodes

(2011) Adrian J. Wolstenholme   International Journal for Parasitology-Drugs and Drug Resistance

Parasite neuropeptide biology: Seeding rational drug target selection?

(2011) Paul McVeigh et al.   International Journal for Parasitology-Drugs and Drug Resistance

P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance

(2011) Anne Lespine et al.   International Journal for Parasitology-Drugs and Drug Resistance

Characterization of the xenobiotic response ofCaenorhabditis elegansto the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites

(2010) Steven T. Laing et al.   BIOCHEMICAL JOURNAL

Epidemiology and control of human gastrointestinal parasites in children

(2010) Michael O Harhay et al.   Expert Review of Anti-Infective Therapy

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spotted spider mite, Tetranychus urticae Koch

(2010) D. H. Kwon et al.   INSECT MOLECULAR BIOLOGY

Anthelmintic resistance: markers for resistance, or susceptibility?

(2010) R. N. BEECH et al.   PARASITOLOGY

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

(2010) C. J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Anthelmintic resistance in nematode parasites of cattle: a global issue?

(2010) Ian A. Sutherland et al.   TRENDS IN PARASITOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths

(2009) Viktor Cvilink et al.   DRUG METABOLISM REVIEWS

Contrasting genetic structures of two parasitic nematodes, determined on the basis of neutral microsatellite markers and selected anthelmintic resistance markers

(2009) A. SILVESTRE et al.   MOLECULAR ECOLOGY

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

(2009) Kirk W. Deitsch et al.   NATURE REVIEWS MICROBIOLOGY

WormBase: a comprehensive resource for nematode research

(2009) Todd W. Harris et al.   NUCLEIC ACIDS RESEARCH

Forty years of helminth biochemistry

(2009) J. BARRETT   PARASITOLOGY

P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus

(2009) D. J. BARTLEY et al.   PARASITOLOGY

Drug resistance mechanisms in helminths: is it survival of the fittest?

(2009) Catherine E. James et al.   TRENDS IN PARASITOLOGY

Parasite control in the age of drug resistance and changing agricultural practices

(2009) Marcelo Beltrão Molento   VETERINARY PARASITOLOGY

Behavioral Impact of Neurotransmitter-Activated G-Protein-Coupled Receptors: Muscarinic and GABAB Receptors Regulate Caenorhabditis elegans Locomotion

(2008) J. S. Dittman et al.   JOURNAL OF NEUROSCIENCE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortus laboratory isolates and provides a rapid system of genetic fingerprinting

(2007) Elizabeth Redman et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY