Mitochondrial Quality Control in Cardiomyocytes: A Critical Role in the Progression of Cardiovascular Diseases

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

(2019) Bereketeab Haileselassie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mst1 deletion reduces septic cardiomyopathy via activating Parkin-related mitophagy

(2019) Xiuling Shang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial dynamics modulation as a critical contribution for Shenmai injection in attenuating hypoxia/reoxygenation injury

(2019) Jiahui Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury

(2019) Xiyun Bian et al.   Oxidative Medicine and Cellular Longevity

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression

(2019) Qi Ren et al.   Artificial Cells Nanomedicine and Biotechnology

Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction

(2019) Yangpo Cao et al.   CIRCULATION RESEARCH

The Good and the Bad of Mitochondrial Breakups

(2019) Hans-Georg Sprenger et al.   TRENDS IN CELL BIOLOGY

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

(2019) Atsushi Hoshino et al.   NATURE

Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing

(2019) Zhen Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

PTENα Regulates Mitophagy and Maintains Mitochondrial Quality Control

(2018) Yuxin Yin et al.   Autophagy

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy

(2018) Shanjie Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes

(2018) Cameron S. Brand et al.   CELLULAR SIGNALLING

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

PTEN induced putative kinase 1 (PINK1) alleviates angiotensin II-induced cardiac injury by ameliorating mitochondrial dysfunction

(2018) Wenjun Xiong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mst1 promotes cardiac ischemia–reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy

(2018) Wancheng Yu et al.   Journal of Physiological Sciences

Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes

(2018) Bong Sook Jhun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Short-Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged Mice

(2018) Dajun Zhao et al.   Oxidative Medicine and Cellular Longevity

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

(2018) Valentina Celestini et al.   Cell Death & Disease

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

(2018) Yue Li et al.   Nature Communications

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

(2018) Qinhua Jin et al.   Redox Biology

Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy

(2018) Jun Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition

(2018) Shanjie Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

(2018) Phung N. Thai et al.   Scientific Reports

Multiple recycling routes: Canonical vs. non-canonical mitophagy in the heart

(2018) Alexandra Moyzis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales

(2018) Yuting Guo et al.   CELL

Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways

(2018) Jixuan Liu et al.   CELLULAR SIGNALLING

Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction

(2018) Hannah A. Cooper et al.   CLINICAL SCIENCE

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

(2018) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates myocardial ischemia reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways

(2018) Ying Zhang et al.   JOURNAL OF PINEAL RESEARCH

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease

(2018) A.U. Joshi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

(2017) Edward Cherok et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

(2017) Anthony R. Anzell et al.   MOLECULAR NEUROBIOLOGY

c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

(2017) Lujun Zhou et al.   Cell Death & Disease

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

(2017) Chun Guo et al.   Scientific Reports

Significance of Mitochondrial Protein Post-translational Modifications in Pathophysiology of Brain Injury

(2017) Nina Klimova et al.   Translational Stroke Research

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

(2017) Tong Wei et al.   Journal of the American Heart Association

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

(2017) Bei Wang et al.   CIRCULATION RESEARCH

Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy

(2016) Sebastien Preau et al.   ANTIOXIDANTS & REDOX SIGNALING

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity

(2016) Yu-Xuan Luo et al.   EUROPEAN HEART JOURNAL

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

(2016) Zhongbao Yue et al.   EXPERIMENTAL CELL RESEARCH

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes

(2016) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DJ-1 protects the heart against ischemia–reperfusion injury by regulating mitochondrial fission

(2016) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system

(2016) Virgilio J. J. Cadete et al.   JOURNAL OF PHYSIOLOGY-LONDON

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Mechanisms and Dynamics of Protein Acetylation in Mitochondria

(2016) Josue Baeza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

(2015) Moshi Song et al.   Cell Metabolism

Molecular Mechanisms of Autophagy in the Cardiovascular System

(2015) D. Gatica et al.   CIRCULATION RESEARCH

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

Mitochondrial biogenesis and dynamics in the developing and diseased heart

(2015) Gerald W. Dorn et al.   GENES & DEVELOPMENT

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system

(2015) Yoshiyuki Ikeda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy

(2015) Eun Young Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

(2015) Aswin Pyakurel et al.   MOLECULAR CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death

(2014) Ivan Zaja et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance

(2014) Lori Buhlman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

(2014) Wen Yue et al.   CELL RESEARCH

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

Mitochondrial quality control in the myocardium: Cooperation between protein degradation and mitophagy

(2014) Babette C. Hammerling et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of Rcan1-1L Inhibits Hypoxia-Induced Cell Apoptosis through Induction of Mitophagy

(2014) Lijun Sun et al.   MOLECULES AND CELLS

Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

(2014) Somak Das et al.   Oxidative Medicine and Cellular Longevity

Activation of the ubiquitin–proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis

(2014) Mayumi Watanabe et al.   TOXICOLOGY

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection

(2012) Qiang Zhang et al.   BIOCHEMICAL JOURNAL

The Interferon Stimulated Gene 12 Inactivates Vasculoprotective Functions of NR4A Nuclear Receptors

(2012) Nikolina Papac-Milicevic et al.   CIRCULATION RESEARCH

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes

(2012) Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

(2012) A H Chaanine et al.   Cell Death & Disease

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

(2011) R. Winkler et al.   DIABETES

Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

(2011) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

(2011) K. N. Papanicolaou et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability

(2011) Sarah R. Horn et al.   MOLECULAR BIOLOGY OF THE CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle

(2010) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission

(2010) Tianzheng Yu et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutation of the protein kinase A phosphorylation site influences the anti-proliferative activity of mitofusin 2

(2010) Wei Zhou et al.   ATHEROSCLEROSIS

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore

(2010) Melissa N. Quinsay et al.   Autophagy

Nix: A receptor protein for mitophagy in mammals

(2010) Tomotake Kanki   Autophagy

Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition

(2010) Sabzali Javadov et al.   BASIC RESEARCH IN CARDIOLOGY

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Autophagy in Atherosclerosis

(2009) Wim Martinet et al.   CIRCULATION RESEARCH

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

(2009) Emélie Braschi et al.   EMBO REPORTS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation

(2008) Abhinav Diwan et al.   CIRCULATION

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY