The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question

(2019) Francisco Barros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals

(2019) Yasushi OKAMURA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism

(2019) Olfat A. Malak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Regulation of Eag1 gating by its intracellular domains

(2019) Jonathan R Whicher et al.   eLife

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

(2019) Marina A Kasimova et al.   eLife

Voltage Sensor Movements during Hyperpolarization in the HCN Channel

(2019) Chia-Hsueh Lee et al.   CELL

Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy

(2018) Carus Lau et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ether-à-go-go K+ channels: effective modulators of neuronal excitability

(2018) Christiane K. Bauer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

(2018) Ana I. Fernández-Mariño et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain

(2018) Pilar de la Peña et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

(2018) Natalia Prevarskaya et al.   PHYSIOLOGICAL REVIEWS

S4–S5 linker movement during activation and inactivation in voltage-gated K+channels

(2018) Tanja Kalstrup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures

(2018) Chia-Hsueh Lee et al.   SCIENCE

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

(2018) Ana I. Fernández-Mariño et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study

(2018) Laura L. Perissinotti et al.   Frontiers in Physiology

Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

(2018) Galen E. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobic gating in BK channels

(2018) Zhiguang Jia et al.   Nature Communications

Relative positioning of Kv11.1 (hERG) K+ channel cytoplasmic domain-located fluorescent tags toward the plasma membrane

(2018) Francisco Barros et al.   Scientific Reports

The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure

(2018) Sara J. Codding et al.   JOURNAL OF GENERAL PHYSIOLOGY

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

(2017) Kevin Phan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the mechanisms of CNBD channel function

(2017) Zachary M. James et al.   JOURNAL OF GENERAL PHYSIOLOGY

The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation

(2017) Yaxian Zhao et al.   JOURNAL OF GENERAL PHYSIOLOGY

A new mechanism of voltage-dependent gating exposed by K V 10.1 channels interrupted between voltage sensor and pore

(2017) Adam P. Tomczak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel

(2017) Yu Zhou et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a eukaryotic cyclic-nucleotide-gated channel

(2017) Minghui Li et al.   NATURE

Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains

(2017) Pilar de la Peña et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel

(2017) Zachary M. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Towards a Structural View of Drug Binding to hERG K + Channels

(2017) Jamie I. Vandenberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state

(2017) Olfat A. Malak et al.   Scientific Reports

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels

(2017) Gucan Dai et al.   eLife

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

(2017) Appu K. Singh et al.   Scientific Reports

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

(2016) J. R. Whicher et al.   SCIENCE

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel

(2016) Juan Zhao et al.   eLife

The Cole-Moore Effect: Still Unexplained?

(2015) Toshinori Hoshi et al.   BIOPHYSICAL JOURNAL

Sequence of Gating Charge Movement and Pore Gating in hERG Activation and Deactivation Pathways

(2015) Samuel J. Goodchild et al.   BIOPHYSICAL JOURNAL

hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma

(2015) E Lastraioli et al.   BRITISH JOURNAL OF CANCER

The Enigmatic Cytoplasmic Regions of KCNH Channels

(2015) João H. Morais-Cabral et al.   JOURNAL OF MOLECULAR BIOLOGY

Getting to the heart of hERG K+channel gating

(2015) Matthew D. Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel

(2015) Richard K. Hite et al.   NATURE

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains

(2015) Éva Lörinczi et al.   Nature Communications

BK channels: multiple sensors, one activation gate

(2015) Huanghe Yang et al.   Frontiers in Physiology

Proline Scan of the hERG Channel S6 Helix Reveals the Location of the Intracellular Pore Gate

(2014) Samrat Thouta et al.   BIOPHYSICAL JOURNAL

Multiple Interactions between Cytoplasmic Domains Regulate Slow Deactivation of Kv11.1 Channels

(2014) Chai Ann Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels

(2014) Sandipan Chowdhury et al.   JOURNAL OF GENERAL PHYSIOLOGY

KV10.1 opposes activity-dependent increase in Ca2+influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse

(2014) Lena Sünke Mortensen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

(2014) Pilar de la Peña et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

hERG channel function: beyond long QT

(2013) Joseph J Babcock et al.   ACTA PHARMACOLOGICA SINICA

Mapping of interactions between the N- and C-termini and the channel core in HERG K+channels

(2013) Pilar de la Peña et al.   BIOCHEMICAL JOURNAL

Gating charge movement precedes ionic current activation in hERG channels

(2013) Samuel J Goodchild et al.   Channels

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

(2013) Zhuren Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

(2013) Elena C. Gianulis et al.   JOURNAL OF GENERAL PHYSIOLOGY

The structural mechanism of KCNH-channel regulation by the eag domain

(2013) Yoni Haitin et al.   NATURE

Structural Properties of PAS Domains from the KCNH Potassium Channels

(2013) Ricardo Adaixo et al.   PLoS One

HERG potassium channel regulation by the N-terminal eag domain

(2012) Ahleah S. Gustina et al.   CELLULAR SIGNALLING

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

(2012) Peter S. Tan et al.   JOURNAL OF GENERAL PHYSIOLOGY

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating

(2012) Chai Ann Ng et al.   PLoS One

Mechanism of Voltage Gating in Potassium Channels

(2012) M. O. Jensen et al.   SCIENCE

Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels

(2012) Rikard Blunck et al.   Frontiers in Pharmacology

Voltage-Dependent Gating of hERG Potassium Channels

(2012) Yen May Cheng et al.   Frontiers in Pharmacology

Coupling of Voltage-Sensors to the Channel Pore: A Comparative View

(2012) Vitya Vardanyan et al.   Frontiers in Pharmacology

Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating

(2012) Francisco Barros et al.   Frontiers in Pharmacology

Demonstration of Physical Proximity between the N Terminus and the S4-S5 Linker of the Humanether-à-go-go-related Gene (hERG) Potassium Channel

(2011) Pilar de la Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

(2011) Chai Ann Ng et al.   PLoS One

Molecular Determinants of Interactions between the N-Terminal Domain and the Transmembrane Core That Modulate hERG K+ Channel Gating

(2011) Jorge Fernández-Trillo et al.   PLoS One

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4–S5 linker

(2010) Qingxin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel

(2010) Xinqiu Liu et al.   Channels

Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

(2010) Frederick W. Muskett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain

(2010) Frank S. Choveau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of surface residues of intracellular domains of heag potassium channels

(2009) Louisa Stevens et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

(2009) A. S. Gustina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRET with multiply labeled HERG K+ channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains

(2008) Pablo Miranda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Thermodynamic and Kinetic Properties of Amino-Terminal and S4-S5 Loop HERG Channel Mutants under Steady-State Conditions

(2008) Carlos Alonso-Ron et al.   BIOPHYSICAL JOURNAL

Targeting Ion Channels in Cancer: A Novel Frontier in Antineoplastic Therapy

(2008) A. Arcangeli et al.   CURRENT MEDICINAL CHEMISTRY

hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling

(2008) Sarah L. Wynia-Smith et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues

(2008) Alain J. Labro et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE

How membrane proteins sense voltage

(2008) Francisco Bezanilla   NATURE REVIEWS MOLECULAR CELL BIOLOGY