Mapping of interactions between the N- and C-termini and the channel core in HERG K+channels

HERG potassium channel regulation by the N-terminal eag domain

(2012) Ahleah S. Gustina et al.   CELLULAR SIGNALLING

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

(2012) Peter S. Tan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the carboxy-terminal region of a KCNH channel

(2012) Tinatin I. Brelidze et al.   NATURE

Voltage-Dependent Gating of hERG Potassium Channels

(2012) Yen May Cheng et al.   Frontiers in Pharmacology

Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating

(2012) Francisco Barros et al.   Frontiers in Pharmacology

Demonstration of Physical Proximity between the N Terminus and the S4-S5 Linker of the Humanether-à-go-go-related Gene (hERG) Potassium Channel

(2011) Pilar de la Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant HumanEther-á-go-go-related Gene Potassium Channels

(2011) Elena C. Gianulis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

(2011) Chai Ann Ng et al.   PLoS One

Molecular Determinants of Interactions between the N-Terminal Domain and the Transmembrane Core That Modulate hERG K+ Channel Gating

(2011) Jorge Fernández-Trillo et al.   PLoS One

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4–S5 linker

(2010) Qingxin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations within the S4–S5 Linker Alter Voltage Sensor Constraints in hERG K+ Channels

(2010) Aaron C. Van Slyke et al.   BIOPHYSICAL JOURNAL

LQTS gene LOVD database

(2010) Tao Zhang et al.   HUMAN MUTATION

An Intersubunit Interaction between S4-S5 Linker and S6 Is Responsible for the Slow Off-gating Component in Shaker K+Channels

(2010) Zarah Batulan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

(2010) Frederick W. Muskett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels

(2010) Katrin Kolbe et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of intracellular domains in the function of the herg potassium channel

(2009) Moza Al-Owais et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

(2009) A. S. Gustina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic and Kinetic Properties of Amino-Terminal and S4-S5 Loop HERG Channel Mutants under Steady-State Conditions

(2008) Carlos Alonso-Ron et al.   BIOPHYSICAL JOURNAL

A Highly Conserved Alanine in the S6 Domain of the hERG1 K+ Channel is Required for Normal Gating

(2008) Scott Brown et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Participation of HERG channel cytoplasmic structures on regulation by the G protein-coupled TRH receptor

(2008) Carlos Alonso-Ron et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination

(2008) Damian C. Bell et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY