Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling

(2019) Yu Xiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways

(2019) Zuoxing Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors

(2019) Manhui Pang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adjunctive use of anti-inflammatory drugs for schizophrenia: A meta-analytic investigation of randomized controlled trials

(2019) Myeongju Cho et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro

(2018) Manar A. Elhinnawi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6/NF-κB/ERK signaling pathway in Raw264.7 cells.

(2018) Buyun Kim et al.   PHYTOMEDICINE

Deguelin inhibits RANKL-induced osteoclastogenesis in vitro and prevents inflammation-mediated bone loss in vivo

(2018) Tan Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis

(2017) Ya-Hui Chiu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis

(2017) Jiaxin Li et al.   Reproductive Biology and Endocrinology

Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation

(2017) Zixian Jiao et al.   Scientific Reports

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

(2017) Jiachao Guo et al.   Frontiers in Pharmacology

Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation

(2016) Ce Dou et al.   Nutrients

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation

(2016) Qian Liu et al.   Scientific Reports

Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways

(2015) Jianjun Ma et al.   BIOCHEMICAL JOURNAL

Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

(2015) Danielle A. Callaway et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice

(2013) Sun-Don Kim et al.   BIOCHEMICAL PHARMACOLOGY

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Steroids and osteoporosis: the quest for mechanisms

(2013) Stavros C. Manolagas   JOURNAL OF CLINICAL INVESTIGATION

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice

(2013) Ryota Shizu et al.   PLoS One

The p38α MAPK positively regulates osteoblast function and postnatal bone acquisition

(2012) Cyril Thouverey et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment

(2012) Atsushi Arai et al.   JOURNAL OF CELL SCIENCE

Luteolin inhibition of V-ATPasea3-d2interaction decreases osteoclast resorptive activity

(2012) Gazelle J. Crasto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

A reassessment of a classic neuroprotective combination therapy for spinal cord injured rats: LPS/pregnenolone/indomethacin

(2011) Phillip G. Popovich et al.   EXPERIMENTAL NEUROLOGY

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence

(2011) C.E. Marx et al.   NEUROSCIENCE

Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones

(2010) Jie Hu et al.   Nutrition & Metabolism

Myocyte Enhancer Factor 2 and Microphthalmia-associated Transcription Factor Cooperate with NFATc1 to Transactivate the V-ATPase d2 Promoter during RANKL-induced Osteoclastogenesis

(2009) HaoTian Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diclofenac Sodium Inhibits NFκB Transcription in Osteoclasts

(2009) A. Karakawa et al.   JOURNAL OF DENTAL RESEARCH

Minireview: Osteoprotective Action of Estrogens Is Mediated by Osteoclastic Estrogen Receptor-α

(2009) Yuuki Imai et al.   MOLECULAR ENDOCRINOLOGY

Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption

(2008) Haiping Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PU.1 and NFATc1 mediate osteoclastic induction of the mouse β3 integrin promoter

(2008) Tania N. Crotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

NFATc1 Induces Osteoclast Fusion Via Up-Regulation of Atp6v0d2 and the Dendritic Cell-Specific Transmembrane Protein (DC-STAMP)

(2007) Kabsun Kim et al.   MOLECULAR ENDOCRINOLOGY